HR + /HER2 − (N = 13,283) | TN (N = 2845) | HR + /HER2 + (N = 2502) | HR − /HER2 + (N = 1403) | Total (N = 20,033) | |
---|---|---|---|---|---|
Age (years) (median, [IQR]) | 62.0 (51.0, 71.0) | 56.0 (45.0, 66.0) | 57.0 (47.0, 67.0) | 56.0 (46.5, 64.0) | 60.0 (50.0, 70.0) |
Personal history of other cancer | 401 (3.0%) | 111 (3.9%) | 75 (3.0%) | 38 (2.7%) | 625 (3.1%) |
Histologic type (primary tumor) | |||||
IDC | 9498 (71.5%) | 2382 (83.7%) | 2045 (81.7%) | 1185 (84.5%) | 15,110 (75.4%) |
ILC | 2263 (17.0%) | 123 (4.3%) | 168 (6.7%) | 44 (3.1%) | 2598 (13.0%) |
IDC + ILC | 149 (1.1%) | 8 (0.3%) | 28 (1.1%) | 4 (0.3%) | 189 (0.9%) |
Other types | 1173 (8.8%) | 296 (10.4%) | 227 (9.1%) | 155 (11.0%) | 1851 (9.2%) |
Not documented | 200 (1.5%) | 36 (1.3%) | 34 (1.4%) | 15 (1.1%) | 285 (1.4%) |
Histological grade (primary tumor) | |||||
Grade 1 | 1532 (11.5%) | 46 (1.6%) | 132 (5.3%) | 16 (1.1%) | 1726 (8.6%) |
Grade 2 | 6883 (51.8%) | 758 (26.6%) | 1125 (45.0%) | 459 (32.7%) | 9225 (46.0%) |
Grade 3 | 2775 (20.9%) | 1662 (58.4%) | 866 (34.6%) | 724 (51.6%) | 6027 (30.1%) |
Not documented | 2093 (15.8%) | 379 (13.3%) | 379 (15.1%) | 204 (14.5%) | 3055 (15.2%) |
De novo mBC disease | |||||
Yes | 4217 (31.7%) | 872 (30.7%) | 1017 (40.6%) | 687 (49.0%) | 6793 (33.9%) |
No | 9066 (68.3%) | 1973 (69.3%) | 1485 (59.4%) | 716 (51.0%) | 13,240 (66.1%) |
For patients without de novo mBC disease: metastasis free interval [MFI] | |||||
− [6:24[ | 1109 (8.3%) | 1043 (36.7%) | 235 (9.4%) | 280 (20.0%) | 2667 (13.3%) |
− [24:48[ | 1939 (14.6%) | 484 (17.0%) | 449 (17.9%) | 238 (17.0%) | 3110 (15.5%) |
− [48:96[ | 2528 (19.0%) | 224 (7.9%) | 423 (16.9%) | 121 (8.6%) | 3296 (16.5%) |
− [96:120[ | 955 (7.2%) | 42 (1.5%) | 112 (4.5%) | 29 (2.1%) | 1138 (5.7%) |
− > = 120 | 2535 (19.1%) | 180 (6.3%) | 266 (10.6%) | 48 (3.4%) | 3029 (15.1%) |
For patients without de novo mBC disease, therapy used in adjuvant setting (*) | |||||
IV chemotherapy | 6094 (67.2%) | 1752 (88.8%) | 1136 (76.5%) | 601 (83.9%) | 9583 (72.4%) |
Oral chemotherapy | 149 (1.6%) | 80 (4.1%) | 52 (3.5%) | 27 (3.8%) | 308 (2.3%) |
Endocrine therapy | 7582 (83.6%) | 76 (3.9%) | 1175 (79.1%) | 30 (4.2%) | 8863 (66.9%) |
Number of metastatic sites at mBC diagnosis | |||||
< 3 | 10,627 (80.0%) | 2135 (75.0%) | 1984 (79.3%) | 1077 (76.8%) | 15,823 (79.0%) |
> = 3 | 2656 (20.0%) | 710 (25.0%) | 518 (20.7%) | 326 (23.2%) | 4210 (21.0%) |
Brain/CNS/CSF metastases | 543 (4.1%) | 359 (12.6%) | 227 (9.1%) | 201 (14.3%) | 1330 (6.6%) |
Bone metastases | 8678 (65.3%) | 1007 (35.4%) | 1375 (55.0%) | 541 (38.6%) | 11,601 (57.9%) |
Liver metastases | 3378 (25.4%) | 787 (27.7%) | 802 (32.1%) | 546 (38.9%) | 5513 (27.5%) |
Lung metastases | 2783 (21.0%) | 1024 (36.0%) | 639 (25.5%) | 420 (29.9%) | 4866 (24.3%) |
Metastatic lymph nodes | 3458 (26.0%) | 1235 (43.4%) | 751 (30.0%) | 506 (36.1%) | 5950 (29.7%) |
Pleural metastases | 1444 (10.9%) | 296 (10.4%) | 178 (7.1%) | 108 (7.7%) | 2026 (10.1%) |