Table 1 Mendelian randomisation (MR) results of causal effects between gut microbiome and cancer risk (P < 5×10-8)
From: Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study
Gut microbiota (exposure) | Cancer type (outcome) | Consortium | Method | Number of SNPs | β | SE | p-value | OR | 95% CI | Correct causal direction | Steiger p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
Phylum Actinobacteria | Breast cancer | Neale Lab | Wald ratio | 1 | 1.11×10−2 | 4.66×10−3 | 1.75×10−2 | 1.01 | 1.001–1.020 | True | 6.36×10−24 |
Class Actinobacteria | Breast cancer | Neale Lab | Wald ratio | 1 | 1.05×10−2 | 3.78×10−3 | 5.62×10−3 | 1.01 | 1.003–1.018 | True | 1.64×10−33 |
Class Actinobacteria | Breast cancer | UK Biobank | IVW | 2 | 1.21×10−2 | 5.41×10−3 | 2.58×10−2 | 1.01 | 1.001–1.022 | True | 2.09×10−17 |
Class Actinobacteria | Breast cancer | MRC-IEU | Wald ratio | 1 | 6.55×10−3 | 3.08×10−3 | 3.32×10−2 | 1.01 | 1.000–1.012 | True | 3.04×10−17 |
Family Bifidobacteriaceae | Breast cancer | Neale Lab | Wald ratio | 1 | 9.97×10−3 | 3.60×10−3 | 5.62×10−3 | 1.01 | 1.002–1.017 | True | 7.79×10−46 |
Order Bifidobacteriales | Breast cancer | Neale Lab | Wald ratio | 1 | 9.97×10−3 | 3.60×10−3 | 5.62×10−3 | 1.01 | 1.002–1.017 | True | 7.79×10−46 |
Genus Ruminococcaceae UCG013 | Breast cancer | Neale Lab | Wald ratio | 1 | −1.63×10−2 | 5.70×10−3 | 4.35×10−3 | 0.98 | 0.972–0.994 | True | 1.12×10−14 |
Phylum.Actinobacteria | Lung cancer | UK Biobank | Wald ratio | 1 | 5.49×10−3 | 2.44×10−3 | 2.42×10−2 | 1.01 | 1.000–1.010 | True | 1.06×10−12 |
Class Actinobacteria | Lung cancer | UK Biobank | Wald ratio | 1 | 4.23×10−3 | 1.97×10−3 | 3.12×10−2 | 1.00 | 1.000–1.008 | True | 7.06×10−18 |
Genus Tyzzerella3 | Lung adenocarcinoma | FINNGEN | Wald ratio | 1 | 1.50 | 0.51 | 3.43×10−3 | 4.49 | 1.641–12.263 | True | 3.12×10−4 |
Genus Tyzzerella3 | Colorectal cancer | UK Biobank | Wald ratio | 1 | −8.05×10−3 | 2.33×10−3 | 5.43×10−4 | 0.99 | 0.987–0.996 | True | 2.95×10−7 |
Genus Ruminococcustorquesgroup | Colorectal cancer | UK Biobank | Wald ratio | 1 | 1.44×10−2 | 4.58×10−3 | 1.63×10−3 | 1.01 | 1.005–1.023 | True | 1.01×10−6 |
Genus Ruminococcustorquesgroup | Prostate cancer | FINNGEN | Wald ratio | 1 | −1.05 | 0.37 | 4.21×10−3 | 0.35 | 0.171–0.718 | True | 5.24×10−7 |
Family Peptostreptococcaceae | Gastric cancer | FINNGEN | Wald ratio | 1 | 2.53 | 0.92 | 6.19×10−3 | 12.52 | 2.049–76.43 | True | 4.21×10−6 |
Order Gastranaerophilales | Oropharyngeal cancer | Oncoarray oral cavity and oropharyngeal cancer | Wald ratio | 1 | −1.28 | 0.55 | 1.92×10−2 | 0.28 | 0.094–0.811 | True | 2.23×10−7 |
Phylum Actinobacteria | Oral cavity cancer | Oncoarray oral cavity and oropharyngeal cancer | Wald ratio | 1 | −3.17 | 1.42 | 2.53×10−2 | 0.04 | 0.002–0.676 | True | 1.52×10−7 |
Class Actinobacteria | Oral cavity cancer | Oncoarray oral cavity and oropharyngeal cancer | Wald ratio | 1 | −2.03 | 0.99 | 3.99×10−2 | 0.13 | 0.019–0.910 | True | 2.01×10−18 |