From: Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study
Gut microbiota (exposure) | Cancer type (outcome) | Consortium | Method | Number of SNPs | β | SE | p-value | OR | 95% CI | Correct causal direction | Steiger p-value |
---|---|---|---|---|---|---|---|---|---|---|---|
Genus Ruminococcusgnavusgroup | Breast cancer | BCAC | IVW | 2 | 0.38 | 8.08×10−2 | 2.16×10−6 | 1.47 | 1.25–1.73 | True | 4.13×10−7 |
Genus Ruminococcusgnavusgroup | ER+ breast cancer | BCAC | IVW | 2 | 0.44 | 9.52×10−2 | 4.27×10−6 | 1.55 | 1.29–1.87 | True | 1.57×10−6 |
Genus Oscillibacter | ER− breast cancer | BCAC | IVW | 2 | 0.72 | 0.20 | 2.59×10−4 | 2.05 | 1.39–3.00 | True | 1.17×10−5 |
Class Gammaproteobacteria | Endometrial cancer | MRC-IEU | Wald ratio | 1 | −6.38×10−3 | 1.91×10−3 | 8.44×10−4 | 0.99 | 0.99–1.00 | True | 2.22×10−5 |
Genus Ruminococcus1 | Head and neck cancer | UK Biobank | Wald ratio | 1 | 8.69×10−3 | 2.34×10−3 | 1.98×10−4 | 1.01 | 1.00–1.01 | True | 9.17×10−12 |
Genus Ruminococcus1 | Oral and oropharyngeal cancer | UK Biobank | Wald ratio | 1 | 7.25×10−3 | 2.04×10−3 | 3.71×10−4 | 1.01 | 1.00–1.01 | True | 8.76×10−12 |
Genus Ruminiclostridium6 | Serous ovarian cancer: low malignant potential | OCAC | Wald ratio | 1 | 2.47 | 0.67 | 2.33×10−4 | 11.87 | 3.18–44.33 | True | 2.83×10−9 |
Order Lactobacillales | Squamous cell lung cancer | ILCCO | IVW | 2 | 1.16 | 0.38 | 2.17×10−3 | 3.18 | 1.52–6.67 | True | 8.74×10−6 |
Order Burkholderiales | Lung cancer | ILCCO | IVW | 3 | −0.59 | 0.20 | 2.75×10−3 | 0.55 | 0.38–0.82 | True | 7.49×10−9 |
Order Lactobacillales | Small cell Lung cancer | FINNGEN | IVW | 2 | 4.23 | 1.43 | 3.06×10−3 | 68.83 | 4.18–1132.80 | True | 6.08×10−6 |
Genus Terrisporobacter | Prostate cancer | FINNGEN | Wald ratio | 1 | −0.96 | 0.24 | 6.79×10−5 | 0.38 | 0.24–0.61 | True | 4.56×10−9 |
Genus Roseburia | Prostate cancer | PRACTICA-L | Wald ratio | 1 | 0.55 | 0.15 | 3.89×10−4 | 1.73 | 1.28–2.34 | True | 3.08×10−13 |
Class Verrucomicrobiae | Prostate cancer | UK Biobank | Wald ratio | 1 | −3.66×10−2 | 1.10×10−2 | 8.73×10−4 | 0.96 | 0.94–0.99 | True | 1.01×10−4 |
Family Verrucomicrobiaceae | Prostate cancer | UK Biobank | Wald ratio | 1 | −3.66×10−2 | 1.10×10−2 | 8.73×10−4 | 0.96 | 0.94–0.99 | True | 1.01×10−4 |
Order Verrucomicrobiales | Prostate cancer | UK Biobank | Wald ratio | 1 | −3.66×10−2 | 1.10×10−2 | 8.73×10−4 | 0.96 | 0.94–0.99 | True | 1.01×10−4 |
Class Alphaproteobacteria | Prostate cancer | PRACTICA-L | IVW | 2 | 0.25 | 7.90×10−2 | 1.29×10−3 | 1.29 | 1.10–1.51 | True | 7.72×10−11 |
Order Verrucomicrobiales | Colorectal cancer | UK Biobank | Wald ratio | 1 | 1.32×10−2 | 4.27×10−3 | 1.98×10−3 | 1.01 | 1.00–1.02 | True | 1.80×10−5 |
Order Desulfovibrionales | Colorectal cancer | UK Biobank | Wald ratio | 1 | 1.53×10−2 | 5.15×10−3 | 2.98×10−3 | 1.02 | 1.00–1.03 | True | 6.97×10−6 |
Family Verrucomicrobiaceae | Colorectal cancer | UK Biobank | Wald ratio | 1 | 1.32×10−2 | 4.27×10−3 | 1.98×10−3 | 1.01 | 1.00–1.02 | True | 1.80×10−5 |
Class Verrucomicrobiae | Colorectal cancer | UK Biobank | Wald ratio | 1 | 1.32×10−2 | 4.27×10−3 | 1.98×10−3 | 1.01 | 1.00–1.02 | True | 1.80×10−5 |
Class Deltaproteobacteria | Colorectal cancer | UK Biobank | Wald ratio | 1 | 1.55×10−2 | 5.15×10−3 | 2.98×10−3 | 1.02 | 1.02–1.03 | True | 9.00×10−6 |