Skip to main content

Table 2 MR results of causal effects between gut microbiome and cancer risk (p < 1×10−6)

From: Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study

Gut microbiota (exposure)

Cancer type (outcome)

Consortium

Method

Number of SNPs

β

SE

p-value

OR

95% CI

Correct causal direction

Steiger p-value

Genus Ruminococcusgnavusgroup

Breast cancer

BCAC

IVW

2

0.38

8.08×10−2

2.16×10−6

1.47

1.25–1.73

True

4.13×10−7

Genus Ruminococcusgnavusgroup

ER+ breast cancer

BCAC

IVW

2

0.44

9.52×10−2

4.27×10−6

1.55

1.29–1.87

True

1.57×10−6

Genus Oscillibacter

ER− breast cancer

BCAC

IVW

2

0.72

0.20

2.59×10−4

2.05

1.39–3.00

True

1.17×10−5

Class Gammaproteobacteria

Endometrial cancer

MRC-IEU

Wald ratio

1

−6.38×10−3

1.91×10−3

8.44×10−4

0.99

0.99–1.00

True

2.22×10−5

Genus Ruminococcus1

Head and neck cancer

UK Biobank

Wald ratio

1

8.69×10−3

2.34×10−3

1.98×10−4

1.01

1.00–1.01

True

9.17×10−12

Genus Ruminococcus1

Oral and oropharyngeal cancer

UK Biobank

Wald ratio

1

7.25×10−3

2.04×10−3

3.71×10−4

1.01

1.00–1.01

True

8.76×10−12

Genus Ruminiclostridium6

Serous ovarian cancer: low malignant potential

OCAC

Wald ratio

1

2.47

0.67

2.33×10−4

11.87

3.18–44.33

True

2.83×10−9

Order Lactobacillales

Squamous cell lung cancer

ILCCO

IVW

2

1.16

0.38

2.17×10−3

3.18

1.52–6.67

True

8.74×10−6

Order Burkholderiales

Lung cancer

ILCCO

IVW

3

−0.59

0.20

2.75×10−3

0.55

0.38–0.82

True

7.49×10−9

Order Lactobacillales

Small cell Lung cancer

FINNGEN

IVW

2

4.23

1.43

3.06×10−3

68.83

4.18–1132.80

True

6.08×10−6

Genus Terrisporobacter

Prostate cancer

FINNGEN

Wald ratio

1

−0.96

0.24

6.79×10−5

0.38

0.24–0.61

True

4.56×10−9

Genus Roseburia

Prostate cancer

PRACTICA-L

Wald ratio

1

0.55

0.15

3.89×10−4

1.73

1.28–2.34

True

3.08×10−13

Class Verrucomicrobiae

Prostate cancer

UK Biobank

Wald ratio

1

−3.66×10−2

1.10×10−2

8.73×10−4

0.96

0.94–0.99

True

1.01×10−4

Family Verrucomicrobiaceae

Prostate cancer

UK Biobank

Wald ratio

1

−3.66×10−2

1.10×10−2

8.73×10−4

0.96

0.94–0.99

True

1.01×10−4

Order Verrucomicrobiales

Prostate cancer

UK Biobank

Wald ratio

1

−3.66×10−2

1.10×10−2

8.73×10−4

0.96

0.94–0.99

True

1.01×10−4

Class Alphaproteobacteria

Prostate cancer

PRACTICA-L

IVW

2

0.25

7.90×10−2

1.29×10−3

1.29

1.10–1.51

True

7.72×10−11

Order Verrucomicrobiales

Colorectal cancer

UK Biobank

Wald ratio

1

1.32×10−2

4.27×10−3

1.98×10−3

1.01

1.00–1.02

True

1.80×10−5

Order Desulfovibrionales

Colorectal cancer

UK Biobank

Wald ratio

1

1.53×10−2

5.15×10−3

2.98×10−3

1.02

1.00–1.03

True

6.97×10−6

Family Verrucomicrobiaceae

Colorectal cancer

UK Biobank

Wald ratio

1

1.32×10−2

4.27×10−3

1.98×10−3

1.01

1.00–1.02

True

1.80×10−5

Class Verrucomicrobiae

Colorectal cancer

UK Biobank

Wald ratio

1

1.32×10−2

4.27×10−3

1.98×10−3

1.01

1.00–1.02

True

1.80×10−5

Class Deltaproteobacteria

Colorectal cancer

UK Biobank

Wald ratio

1

1.55×10−2

5.15×10−3

2.98×10−3

1.02

1.02–1.03

True

9.00×10−6