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Table 3 Association of interaction between maternal hypertensive disorders and maternal diabetes history with diabetes in offspring

From: Maternal hypertensive disorders during pregnancy and the risk of offspring diabetes mellitus in childhood, adolescence, and early adulthood: a nationwide population-based cohort study

Outcomes

Maternal HDP

Maternal diabetes

No. of diabetes cases

Rate (1/1000 person-years)

cHRa (95%CI)

aHRb (95%CI)

Diabetes mellitus

No

No

23,004

0.51

1.00 (Reference)

1.00 (Reference)

 

Yes

No

1137

0.64

1.27 (1.20–1.35)

1.27 (1.19–1.35)

 

No

Yes

641

1.43

3.87 (3.57–4.18)

3.67 (3.39–3.97)

 

Yes

Yes

110

1.79

4.85 (4.02–5.85)

4.64 (3.85–5.60)

Type 1 diabetes

No

No

10,267

0.23

1.00 (Reference)

1.00 (Reference)

 

Yes

No

433

0.24

1.08 (0.98–1.19)

1.05 (0.96–1.16)

 

No

Yes

332

0.74

3.44 (3.08–3.83)

3.12 (2.79–3.48)

 

Yes

Yes

60

0.97

4.55 (3.53–5.86)

4.04 (3.13–5.22)

Type 2 diabetes

No

No

3718

0.08

1.00 (Reference)

1.00 (Reference)

 

Yes

No

230

0.13

1.60 (1.40–1.83)

1.63 (1.43–1.87)

 

No

Yes

154

0.34

6.68 (5.68–7.85)

6.99 (5.94–8.22)

 

Yes

Yes

22

0.36

6.95 (4.57–10.57)

7.41 (4.87–11.27)

Gestational diabetes†

No

No

9019

1.13

1.00 (Reference)

1.00 (Reference)

 

Yes

No

474

1.56

1.38 (1.26–1.51)

1.36 (1.24–1.50)

 

No

Yes

155

3.74

3.69 (3.15–4.33)

3.35 (2.85–3.95)

 

Yes

Yes

28

4.94

5.07 (3.50–7.34)

4.67 (3.22–6.77)

  1. aHR adjusted hazard ratio, cHR crude hazard ratio, HDP hypertensive disorders during pregnancy, CI confidence interval
  2. aModel 1: using offspring’s age as time scale
  3. bModel 2: using offspring’s age as time scale; adjusted for calendar year of birth, maternal age, maternal country of origin, maternal residence at birth, maternal cohabitation at birth, maternal educational level, maternal income categories at birth, maternal pre-pregnancy BMI, maternal smoking status during pregnancy, singleton status, paternal diabetes history before childbirth, parity, and sex of offspring
  4. †The analysis of gestational diabetes was restricted to female offspring who had been pregnant