Skip to main content

Table 2 IC50 values (μM) of the 5 most effective invasion-inhibiting drugs with limited or no implications in cancer or metastasis. PC-3 and DU 145 cells expressing different forms of KLF5 were used

From: Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer

 

PC-3 (KLF5 null)

DU 145 (KLF5 null)

KLF5

KLF5K369Q

KLF5K369R

KLF5

KLF5K369Q

KLF5K369R

Furagin

17.3 ± 2.2

28.6 ± 1.9

100.9 ± 27.9

31.4 ± 4.0

63.3 ± 2.4

358.9 ± 127.2

Nifuratel

32.0 ± 1.6

18.6 ± 0.7

18.7 ± 1.0

7.1 ± 0.7

16.2 ± 0.8

14.0 ± 0.2

Nitazoxanide

7.0 ± 0.7

5.4 ± 0.5***

11.4 ± 1.0

55.6 ± 1.4

22.7 ± 2.3**

49.2 ± 10.1

Retapamulin

1.6 ± 0.3

12.6 ± 2.3

12.2 ± 1.1

13.7 ± 2.7

14.7 ± 1.5

11.1 ± 0.8