Table 2 Overview of results of meta-analyzed models

Main models

Binomial regressions

1. Association of childhood maltreatment with depression^a

13

No depression

115,959

ref

Depression

39,910

2.82 [2.40; 3.30]

2. Association of childhood maltreatment with cardiometabolic disease^a

13

No cardiometabolic disease

162,511

ref

Cardiometabolic disease

15,421

1.34 [1.23; 1.46]

2a. Outcome: diabetes mellitus¹

12

No diabetes

168,943

ref

Diabetes

7330

1.35 [1.19; 1.53]

2b. Outcome: cardiovascular disease^a

11

No cardiovascular disease

165,502

ref

Cardiovascular disease

9216

1.39 [1.26; 1.54]

Multinomial logistic regressions

3. Association of childhood maltreatment with comorbidity status^a

9

Healthy controls

99,191

ref

Depression only

34,360

2.68 [2.39; 3.00]

Cardiometabolic disease only

9051

1.27 [1.18; 1.37]

Comorbidity

3565

3.04 [2.51; 3.68]

4. Model 3 + adjustment of lifestyle factors^b

9

Healthy controls

90,166

ref

Depression only

30,544

2.57 [2.28; 2.89]

Cardiometabolic disease only

8181

1.25 [1.15; 1.36]

Comorbidity

3175

2.99 [2.46; 3.63]

5a. Model 3 in males only^a

7

Healthy controls

46,327

ref

Depression only

10,402

2.92 [2.51; 3.40]

Cardiometabolic disease only

5314

1.13 [1.01; 1.27]

Comorbidity

1582

2.90 [2.37; 3.53]

5b. Model 3 in females only^a

8

Healthy controls

49,571

ref

Depression only

23,167

2.59 [2.30; 2.91]

Cardiometabolic disease only

3438

1.41 [1.26; 1.57]

Comorbidity

1942

3.49 [2.79; 4.36]

6. Model 3 with predictors^a = 

Physical abuse

6

Healthy controls

88,347^c

ref

Depression only

32,198^c

1.53 [1.41; 1.66]

Cardiometabolic disease only

8481^c

1.45 [1.24;1.71]

Comorbidity

3411^c

2.06 [1.78; 2.39]

Emotional abuse

Healthy controls

88,347^c

ref

Depression only

32,198^c

2.87 [2.56; 3.22]

Cardiometabolic disease only

8481^c

1.29 [1.11; 1.49]

Comorbidity

3411^c

[2.16; 3.83]

Sexual abuse

Healthy controls

88,347^c

ref

Depression only

32,198^c

1.66 [1.56; 1.76]

Cardiometabolic disease only

8481^c

1.09 [1.01; 1.17]

Comorbidity

3411^c

1.60 [1.19; 2.15]

7. Model 3 with cumulation of maltreatment types as predictor^a = 

1 type (vs. 0 type)

6

Healthy controls

88,347^c

ref

Depression only

32,198^c

2.32 [2.22; 2.41]

Cardiometabolic disease only

8482^c

1.17 [1.07; 1.28]

Comorbidity

3411^c

2.37 [1.87; 3.01]

2 or more types (vs. 0 type)

Healthy controls

88,347^c

ref

Depression only

32,198^c

5.14 [3.93; 6.72]

Cardiometabolic disease only

8482^c

1.83 [1.49; 2.26]

Comorbidity

3411^c

5.96 [3.59; 9.90]

Sensitivity analyses—multinomial logistic regressions

8. Model 3 with outcome = comorbidity status based on strict definition of cardiovascular disease^a

9

Healthy controls

101,203

ref

Depression only

35,279

2.66 [2.37; 2.98]

Cardiometabolic disease only

7030

1.28 [1.18; 1.40]

Comorbidity

2643

3.09 [2.54; 3.75]

9. Model 3 with outcome = comorbidity status based on broad definition of cardiovascular disease^a

11

Healthy controls

81,817

ref

Depression only

28,612

2.84 [2.41; 3.35]

Cardiometabolic disease only

27,178

1.11 [1.06; 1.17]

Comorbidity

10,364

3.00 [2.69; 3.36]

10. Model 3 with outcome = comorbidity status based on medication intake in addition to reports of diagnoses^a

7

Healthy controls

78,989

ref

Depression only

31,266

2.83 [2.27; 3.53]

Cardiometabolic disease only

16,896

1.13 [1.00; 1.26]

Comorbidity

6517

2.76 [2.28; 3.35]