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Table 2 The association between various systematic information indicators and three arrhythmia subtypes

From: Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohort

Variables

Atrial fibrillation/flutter

Ventricular arrhythmia

Bradyarrhythmia

Model 1

Model 2

Model 3

Model 1

Model 2

Model 3

Model 1

Model 2

Model 3

C-reactive protein (mg/L)

 <0.5

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

 (0.5, 1.0)

1.10 (1.05~1.16)

0.99 (0.94~1.04)

1.00 (0.95~1.05)

1.10 (0.97~1.25)

1.03 (0.90~1.17)

1.06 (0.93~1.20)

1.11 (1.04~1.20)

1.02 (0.94~1.09)

1.04 (0.97~1.13)

 (1.0, 2.0)

1.21 (1.16~1.27)

0.98 (0.94~1.03)

1.00 (0.95~1.05)

1.32 (1.17~1.48)

1.15 (1.01~1.30)

1.20 (1.06~1.36)

1.16 ((1.08~1.24)

0.98 (0.91~1.06)

1.03 (0.96~1.11)

 (2.0, 3.0)

1.37 (1.30~1.44)

1.02 (0.96~1.08)

1.04 (0.98~1.10)

1.32 (1.16~1.51)

1.06 (0.92~1.23)

1.13 (0.98~1.30)

1.26 (1.17~1.37)

1.01 (0.93~1.10)

1.07 (0.98~1.16)

 (3.0, 4.0)

1.47 (1.39~1.56)

1.04 (0.97~1.10)

1.06 (0.99~1.13)

1.54 (1.32~1.79)

1.20 (1.02~1.42)

1.28 (1.09~1.51)

1.42 (1.30~1.55)

1.08 (0.98~1.19)

1.15 (1.05~1.27)

 (4.0, 10.0)

1.72 (1.63~1.81)

1.12 (1.06~1.19)

1.14 (1.07~1.20)

1.92 (1.69~2.18)

1.37 (1.19~1.58)

1.45 (1.26~1.67)

1.54 (1.42~1.66)

1.11 (1.02~1.21)

1.18 (1.08~1.29)

 >=10.0

2.10 (1.97~2.23)

1.33 (1.24~1.43)

1.33 (1.24~1.43)

2.55 (2.18~2.98)

1.81 (1.53~2.16)

1.87 (1.57~2.22)

1.68 (1.52~1.86)

1.23 (1.10~1.37)

1.30 (1.16~1.45)

Neutrophil count (10^9 cells/L)

 <2.0

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

 (2.0, 3.0)

0.97 (0.86~1.09)

1.00 (0.88~1.13)

1.02 (0.90~1.16)

1.06 (0.77~1.45)

1.07 (0.77~1.49)

1.10 (0.79~1.53)

0.85 (0.72~1.00)

0.84 (0.70~1.00)

0.85 (0.71~1.01)

 (3.0, 4.0)

1.02 (0.91~1.14)

0.98 (0.87~1.11)

0.99 (0.88~1.11)

1.21 (0.90~1.64)

1.13 (0.82~1.56)

1.14 (0.83~1.56)

0.93 (0.80~1.10)

0.89 (0.75~1.05)

0.88 (0.74~1.04)

 (4.0, 5.0)

1.14 (1.02~1.28)

1.05 (0.93~1.18)

1.03 (0.91~1.16)

1.34 (0.99~1.81)

1.19 (0.87~1.64)

1.17 (0.85~1.60)

1.02 (0.87~1.20)

0.93 (0.79~1.10)

0.90 (0.76~1.06)

 (5.0, 6.0)

1.29 (1.15~1.45)

1.12 (0.99~1.26)

1.08 (0.95~1.22)

1.82 (1.34~2.47)

1.52 (1.10~2.09)

1.43 (1.04~1.97)

1.15 (0.98~1.36)

1.01 (0.85~1.20)

0.94 (0.79~1.11)

 (6.0, 7.5)

1.53 (1.36~1.72)

1.25 (1.10~1.41)

1.17 (1.03~1.33)

2.18 (1.59~2.97)

1.73 (1.24~2.40)

1.57 (1.13~2.18)

1.28 (1.08~1.51)

1.07 (0.90~1.28)

0.98 (0.82~1.17)

 >=7.5

1.88 (1.65~2.13)

1.49 (1.30~1.71)

1.36 (1.19~1.55)

3.35 (2.42~4.64)

2.43 (1.72~3.43)

2.13 (1.51~3.01)

1.42 (1.17~1.71)

1.19 (0.98~1.45)

1.05 (0.86~1.28)

Monocyte count (10^9 cells/L)

 <0.3

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

 (0.3, 0.4)

0.98 (0.92~1.04)

1.00 (0.94~1.06)

1.00 (0.94~1.06)

0.91 (0.78~1.07)

0.93 (0.79~1.09)

0.93 (0.79~1.1)

0.95 (0.86~1.04)

0.97 (0.88~1.07)

0.97 (0.88~1.07)

 (0.4, 0.5)

1.03 (0.98~1.09)

1.01 (0.95~1.07)

1.00 (0.94~1.06)

1.01 (0.87~1.17)

1.03 (0.88~1.20)

1.02 (0.87~1.19)

0.98 (0.90~1.07)

0.98 (0.90~1.08)

0.97 (0.89~1.06)

 (0.5, 0.6)

1.11 (1.05~1.18)

1.04 (0.98~1.10)

1.02 (0.96~1.08)

1.17 (1.01~1.36)

1.11 (0.95~1.30)

1.09 (0.93~1.27)

1.06 (0.97~1.16)

1.01 (0.92~1.11)

0.99 (0.90~1.08)

 (0.6, 0.7)

1.24 (1.17~1.32)

1.11 (1.04~1.19)

1.08 (1.01~1.15)

1.24 (1.06~1.45)

1.11 (0.94~1.31)

1.06 (0.90~1.25)

1.15 (1.05~1.26)

1.07 (0.97~1.18)

1.02 (0.93~1.13)

 (0.7, 0.8)

1.40 (1.31~1.50)

1.20 (1.11~1.28)

1.13 (1.05~1.22)

1.57 (1.33~1.86)

1.38 (1.15~1.65)

1.27 (1.06~1.53)

1.34 (1.21~1.48)

1.19 (1.07~1.32)

1.11 (1.00~1.24)

 >=0.8

1.58 (1.47~1.69)

1.28 (1.19~1.38)

1.18 (1.10~1.27)

2.14 (1.81~2.52)

1.79 (1.50~2.13)

1.58 (1.33~1.89)

1.3 (1.17~1.45)

1.14 (1.02~1.28)

1.03 (0.92~1.15)

Lymphocyte count (10^9 cells/L)

 <0.8

1.55 (1.37~1.75)

1.74 (1.53~1.98)

1.56 (1.38~1.78)

1.57 (1.17~2.12)

1.59 (1.14~2.22)

1.39 (0.99~1.95)

1.34 (1.11~1.63)

1.42 (1.15~1.74)

1.33 (1.08~1.64)

 (0.8, 1.5)

1.01 (0.98~1.05)

1.15 (1.10~1.19)

1.13 (1.09~1.18)

1.04 (0.94~1.14)

1.18 (1.07~1.31)

1.16 (1.05~1.29)

0.97 (0.91~1.02)

1.04 (0.98~1.11)

1.04 (0.98~1.10)

 (1.5, 2.0)

0.99 (0.96~1.03)

1.06 (1.02~1.1)

1.05 (1.02~1.09)

0.89 (0.82~0.98)

0.97 (0.88~1.06)

0.97 (0.88~1.06)

0.99 (0.94~1.05)

1.04 (0.98~1.09)

1.04 (0.98~1.09)

 (2.0, 2.5)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

 (2.5, 3.0)

1.04 (0.99~1.09)

0.98 (0.93~1.03)

0.97 (0.92~1.02)

1.09 (0.97~1.23)

1.01 (0.90~1.15)

0.99 (0.88~1.12)

1.02 (0.95~1.10)

0.96 (0.89~1.03)

0.94 (0.87~1.01)

 (3.0, 4.0)

1.17 (1.10~1.24)

1.02 (0.95~1.08)

0.99 (0.93~1.06)

1.32 (1.14~1.53)

1.13 (0.97~1.32)

1.08 (0.92~1.26)

1.32 (1.21~1.44)

1.23 (1.12~1.35)

1.18 (1.07~1.29)

 >=4.0

1.35 (1.18~1.53)

1.17 (1.02~1.35)

1.10 (0.96~1.27)

1.66 (1.23~2.25)

1.39 (1.00~1.93)

1.28 (0.92~1.77)

1.32 (1.08~1.61)

1.17 (0.94~1.46)

1.11 (0.89~1.38)

Systemic immune-inflammation index (SII)

 <300

1.08 (1.02~1.13)

1.07 (1.01~1.13)

1.07 (1.01~1.13)

1.15 (1.00~1.31)

1.15 (1.00~1.32)

1.14 (0.99~1.31)

1.11 (1.03~1.20)

1.10 (1.02~1.19)

1.11 (1.02~1.20)

 (300, 400)

1.06 (1.01~1.10)

1.05 (1.00~1.10)

1.06 (1.01~1.11)

1.13 (1.01~1.28)

1.13 (1.00~1.27)

1.13 (1.00~1.28)

1.01 (0.94~1.08)

1.00 (0.93~1.07)

1.00 (0.93~1.08)

 (400, 500)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

 (500, 600)

1.05 (1.01~1.10)

1.04 (0.99~1.08)

1.03 (0.98~1.08)

1.16 (1.03~1.31)

1.14 (1.01~1.29)

1.14 (1.01~1.29)

1.03 (0.96~1.10)

1.02 (0.95~1.10)

1.02 (0.95~1.09)

 (600, 800)

1.11 (1.06~1.16)

1.09 (1.04~1.13)

1.07 (1.02~1.11)

1.20 (1.07~1.34)

1.18 (1.05~1.32)

1.16 (1.03~1.30)

1.08 (1.01~1.15)

1.06 (1,00~1.14)

1.05 (0.98~1.12)

 (800, 1500)

1.22 (1.17~1.27)

1.18 (1.13~1.23)

1.13 (1.08~1.19)

1.54 (1.38~1.72)

1.46 (1.30~1.65)

1.41 (1.25~1.58)

1.15 (1.08~1.23)

1.12 (1.04~1.20)

1.08 (1.01~1.16)

 >=1500

1.69 (1.56~1.83)

1.62 (1.49~1.77)

1.48 (1.36~1.62)

2.88 (2.41~3.44)

2.65 (2.19~3.21)

2.39 (1.98~2.9)

1.39 (1.22~1.58)

1.37 (1.19~1.58)

1.29 (1.12~1.49)

Neutrophil-to-lymphocyte ratio (NLR)

 <1.5

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

 (1.5, 2.0)

1.00 (0.96~1.04)

1.00 (0.96~1.05)

0.99 (0.95~1.04)

1.04 (0.93~1.17)

1.02 (0.91~1.15)

1.01 (0.90~1.14)

0.99 (0.93~1.06)

0.99 (0.92~1.06)

0.98 (0.91~1.05)

 (2.0, 2.5)

1.07 (1.02~1.12)

1.06 (1.02~1.11)

1.04 (1.00~1.09)

1.14 (1.02~1.28)

1.13 (1.00~1.27)

1.10 (0.98~1.24)

1.04 (0.97~1.11)

1.03 (0.97~1.11)

1.01 (0.94~1.08)

 (2.5, 3.0)

1.15 (1.10~1.21)

1.13 (1.07~1.19)

1.10 (1.04~1.15)

1.18 (1.04~1.33)

1.14 (1.00~1.30)

1.10 (0.96~1.25)

1.06 (0.99~1.14)

1.05 (0.98~1.14)

1.02 (0.94~1.10)

 (3.0, 3.5)

1.22 (1.16~1.29)

1.21 (1.14~1.28)

1.16 (1.10~1.22)

1.33 (1.16~1.53)

1.29 (1.12~1.49)

1.22 (1.06~1.41)

1.18 (1.09~1.28)

1.17 (1.08~1.28)

1.12 (1.03~1.21)

 (3.5, 5.0)

1.36 (1.29~1.44)

1.36 (1.29~1.43)

1.28 (1.21~1.35)

1.69 (1.48~1.92)

1.61 (1.41~1.85)

1.49 (1.30~1.71)

1.19 (1.10~1.29)

1.17 (1.08~1.27)

1.10 (1.01~1.20)

 >=5.0

1.64 (1.53~1.77)

1.62 (1.50~1.75)

1.46 (1.35~1.58)

2.33 (1.97~2.75)

2.18 (1.82~2.61)

1.91 (1.59~2.28)

1.38 (1.23~1.55)

1.36 (1.20~1.53)

1.23 (1.09~1.39)

Platelet-to-lymphocyte ratio (PLR)

 <80

1.22 (1.16~1.28)

1.11 (1.05~1.17)

1.08 (1.02~1.14)

1.40 (1.23~1.59)

1.22 (1.07~1.40)

1.15 (1.00~1.32)

1.23 (1.14~1.33)

1.14 (1.05~1.24)

1.10 (1.01~1.19)

 (80, 100)

1.09 (1.05~1.14)

1.05 (1.00~1.10)

1.04 (0.99~1.09)

1.22 (1.08~1.36)

1.12 (1.00~1.27)

1.10 (0.97~1.24)

1.05 (0.98~1.13)

1.02 (0.95~1.09)

1.01 (0.94~1.08)

 (100, 120)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

 (120, 150)

0.99 (0.95~1.03)

1.02 (0.98~1.06)

1.02 (0.97~1.06)

1.01 (0.91~1.12)

1.04 (0.93~1.16)

1.04 (0.94~1.16)

0.97 (0.91~1.03)

0.98 (0.92~1.04)

0.98 (0.92~1.05)

 (150, 200)

0.98 (0.94~1.02)

1.04 (0.99~1.08)

1.04 (0.99~1.08)

0.94 (0.85~1.05)

1.00 (0.9~1.12)

1.01 (0.90~1.13)

0.93 (0.87~0.99)

0.97 (0.91~1.03)

0.98 (0.92~1.04)

 (200, 250)

0.98 (0.92~1.03)

1.06 (0.99~1.12)

1.04 (0.98~1.11)

1.17 (1.02~1.35)

1.24 (1.07~1.44)

1.24 (1.07~1.44)

0.96 (0.88~1.05)

1.01 (0.92~1.10)

1.01 (0.93~1.11)

 >=250

1.12 (1.05~1.21)

1.26 (1.17~1.35)

1.19 (1.10~1.28)

1.50 (1.27~1.77)

1.56 (1.31~1.86)

1.47 (1.24~1.76)

1.06 (0.95~1.18)

1.14 (1.01~1.27)

1.11 (0.99~1.24)

Lymphocyte-to-monocyte ratio (LMR)

 <2.5

1.47 (1.39~1.56)

1.49 (1.40~1.58)

1.39 (1.30~1.47)

1.79 (1.54~2.07)

1.82 (1.55~2.13)

1.66 (1.42~1.95)

1.25 (1.15~1.37)

1.23 (1.12~1.35)

1.16 (1.06~1.27)

 (2.5, 3.0)

1.23 (1.16~1.31)

1.24 (1.17~1.32)

1.19 (1.12~1.27)

1.54 (1.32~1.79)

1.63 (1.39~1.91)

1.55 (1.33~1.82)

1.06 (0.97~1.15)

1.04 (0.94~1.14)

1.00 (0.91~1.10)

 (3.0, 4.0)

1.14 (1.08~1.20)

1.15 (1.09~1.21)

1.12 (1.06~1.19)

1.19 (1.04~1.37)

1.27 (1.10~1.47)

1.24 (1.07~1.43)

1.05 (0.98~1.14)

1.05 (0.97~1.14)

1.03 (0.95~1.11)

 (4.0, 5.0)

1.07 (1.01~1.12)

1.08 (1.02~1.14)

1.07 (1.01~1.13)

1.15 (1.00~1.33)

1.2 (1.03~1.39)

1.19 (1.03~1.38)

0.99 (0.91~1.07)

0.98 (0.90~1.06)

0.97 (0.89~1.06)

 (5.0, 6.0)

1.04 (0.98~1.10)

1.05 (0.99~1.11)

1.04 (0.98~1.11)

1.05 (0.90~1.22)

1.07 (0.91~1.26)

1.07 (0.91~1.27)

0.98 (0.89~1.07)

0.96 (0.87~1.05)

0.96 (0.87~1.05)

 (6.0, 8.0)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

 >=8.0

1.05 (0.97~1.14)

1.02 (0.94~1.11)

1.02 (0.93~1.11)

1.32 (1.08~1.61)

1.28 (1.03~1.58)

1.28 (1.03~1.58)

1.08 (0.96~1.22)

1.07 (0.94~1.21)

1.07 (0.94~1.21)

  1. Ref Reference
  2. Model 1: Adjusted age, sex, and race
  3. Model 2: Adjusted Model 1+townsend deprivation index, education, BMI, smoking status, frequency of alcohol drinking, and physical activity
  4. Model 3: Adjusted Model 2+hypertension, heart attack, angina, stroke, diabetes, hyperlipidemia, diseases of blood and blood-forming organs, chronic diseases involving the immune mechanism, and malignant neoplasms