Variable | Analytic sample 1 | Analytic sample 2 | ||||||
---|---|---|---|---|---|---|---|---|
Total (N=13,388) | No CVD (N=12,008) | CVD (N=1380) | P value | Total (N=6101) | No T2DM (N=5914) | T2DM (N=187) | P value | |
Cancer typea | Â | Â | Â | Â | Â | Â | Â | Â |
 Breast cancer | 5500 (41.1) | 5092 (42.4) | 408 (29.6) | <0.001 | 2488 (40.8) | 2418 (40.9) | 70 (37.4) | 0.365 |
 Colorectal cancer | 1064 (8.0) | 938 (7.8) | 126 (9.1) | 0.086 | 524 (8.6) | 511 (8.6) | 13 (7.0) | 0.507 |
 Prostate cancer | 958 (7.2) | 793 (6.6) | 165 (12.0) | <0.001 | 427 (7.0) | 406 (6.9) | 21 (11.2) | 0.028 |
 Kidney cancer | 208 (1.6) | 172 (1.4) | 36 (2.6) | 0.001 | 115 (1.9) | 107 (1.8) | 8 (4.3) | 0.024 |
 Other | 5773 (43.1) | 5118 (42.6) | 655 (47.5) | <0.001 | 2598 (42.6) | 2522 (42.6) | 76 (40.6) | 0.600 |
Age, years | 61.9 (56.4, 65.7) | 61.7 (56.0, 65.5) | 63.6 (59.8, 66.9) | <0.001 | 62.1 (56.8, 65.8) | 62.0 (56.7, 65.8) | 63.7 (60.0, 67.2) | <0.001 |
Sex | Â | Â | Â | <0.001 | Â | Â | Â | <0.001 |
 Female | 9641 (72.0) | 8874 (73.9) | 767 (55.6) |  | 4376 (71.7) | 4264 (72.1) | 112 (59.9) |  |
 Male | 3747 (28.0) | 3134 (26.1) | 613 (44.4) |  | 1725 (28.3) | 1650 (27.9) | 75 (40.1) |  |
Ethnicity | Â | Â | Â | 0.142 | Â | Â | Â | 0.002 |
 White | 13,072 (97.6) | 11,733 (97.7) | 1339 (97.0) |  | 6005 (98.4) | 5827 (98.5) | 178 (95.2) |  |
 Mixed background | 46 (0.3) | 41 (0.3) | 5 (0.4) |  | 14 (0.2) | 12 (0.2) | 2 (1.1) |  |
 Asian | 91 (0.7) | 74 (0.6) | 17 (1.2) |  | 31 (0.5) | 27 (0.5) | 4 (2.1) |  |
 Black | 92 (0.7) | 84 (0.7) | 8 (0.6) |  | 25 (0.4) | 24 (0.4) | 1 (0.5) |  |
 Chinese | 23 (0.2) | 21 (0.2) | 2 (0.1) |  | 7 (0.1) | 6 (0.1) | 1 (0.5) |  |
 Other backgrounds | 64 (0.5) | 55 (0.5) | 9 (0.7) |  | 19 (0.3) | 18 (0.3) | 1 (0.5) |  |
Educational attainment | Â | Â | Â | <0.001 | Â | Â | Â | 0.007 |
 High | 4129 (30.8) | 3782 (31.5) | 347 (25.1) |  | 1855 (30.4) | 1812 (30.6) | 43 (23.0) |  |
 Intermediate | 4378 (32.7) | 3972 (33.1) | 406 (29.4) |  | 1926 (31.6) | 1873 (31.7) | 53 (28.3) |  |
 Low | 4881 (36.5) | 4254 (35.4) | 627 (45.4) |  | 2320 (38.0) | 2229 (37.7) | 91 (48.7) |  |
Occupational status | Â | Â | Â | <0.001 | Â | Â | Â | 0.009 |
 Working | 5618 (42.0) | 5175 (43.1) | 443 (32.1) |  | 2480 (40.6) | 2424 (41.0) | 56 (29.9) |  |
 Retired | 6751 (50.4) | 5930 (49.4) | 821 (59.5) |  | 3172 (52.0) | 3059 (51.7) | 113 (60.4) |  |
 Otherb | 1019 (7.6) | 903 (7.5) | 116 (8.4) |  | 449 (7.4) | 431 (7.3) | 18 (9.6) |  |
Townsend deprivation index | -2.4 (-3.7, 0.0) | -2.4 (-3.7, -0.0) | -2.2 (-3.5, 0.6) | 0.001 | -2.4 (-3.8, 0.0) | -2.4 (-3.8, 0.0) | -2.4 (-3.6, 0.4) | 0.493 |
Alcohol consumption | Â | Â | Â | 0.002 | Â | Â | Â | 0.083 |
 Never or occasional | 2791 (20.8) | 2459 (20.5) | 332 (24.1) |  | 1253 (20.5) | 1202 (20.3) | 51 (27.3) |  |
 1–3 times/month | 1464 (10.9) | 1299 (10.8) | 165 (12.0) |  | 685 (11.2) | 661 (11.2) | 24 (12.8) |  |
 1–4 times/week | 6369 (47.6) | 5771 (48.1) | 598 (43.3) |  | 2889 (47.4) | 2811 (47.5) | 78 (41.7) |  |
 Daily | 2764 (20.6) | 2479 (20.6) | 285 (20.7) |  | 1274 (20.9) | 1240 (21.0) | 34 (18.2) |  |
Smoking status | Â | Â | Â | <0.001 | Â | Â | Â | 0.711 |
 Non-smoker | 7112 (53.1) | 6510 (54.2) | 602 (43.6) |  | 3209 (52.6) | 3116 (52.7) | 93 (49.7) |  |
 Ever-smoker | 5044 (37.7) | 4431 (36.9) | 613 (44.4) |  | 2332 (38.2) | 2257 (38.2) | 75 (40.1) |  |
 Current smoker | 1232 (9.2) | 1067 (8.9) | 165 (12.0) |  | 560 (9.2) | 541 (9.1) | 19 (10.2) |  |
Regular exercise, yes | 7111 (53.1) | 6443 (53.7) | 668 (48.4) | <0.001 | 3286 (53.9) | 3213 (54.3) | 73 (39.0) | <0.001 |
BMI, kg/m2 | 26.4 (23.8, 29.6) | 26.3 (23.8, 29.5) | 27.4 (24.6, 30.8) | <0.001 | 26.4 (23.8, 29.4) | 26.3 (23.8, 29.3) | 30.3 (27.7, 33.3) | <0.001 |
Family history of CVD, yes | 8016 (59.9) | 7127 (59.4) | 889 (64.4) | <0.001 | — | — | — | — |
Family history of diabetes, yes | — | — | — | — | 1183 (19.4) | 1119 (18.9) | 64 (34.2) | <0.001 |
FP_Frailty | Â | Â | Â | <0.001 | Â | Â | Â | <0.001 |
 Non-frail | 6598 (49.3) | 6016 (50.1) | 582 (42.2) |  | 3039 (49.8) | 2977 (50.3) | 62 (33.2) |  |
 Pre-frail | 6114 (45.7) | 5460 (45.5) | 654 (47.4) |  | 2755 (45.2) | 2647 (44.8) | 108 (57.8) |  |
 Frail | 676 (5.0) | 532 (4.4) | 144 (10.4) |  | 307 (5.0) | 290 (4.9) | 17 (9.1) |  |
FI_Frailty | Â | Â | Â | <0.001 | Â | Â | Â | <0.001 |
 Non-frail | 4247 (31.7) | 3965 (33.0) | 282 (20.4) |  | 1894 (31.0) | 1872 (31.7) | 22 (11.8) |  |
 Pre-frail | 7077 (52.9) | 6324 (52.7) | 753 (54.6) |  | 3249 (53.3) | 3140 (53.1) | 109 (58.3) |  |
 Frail | 2064 (15.4) | 1719 (14.3) | 345 (25.0) |  | 958 (15.7) | 902 (15.3) | 56 (29.9) |  |