Table 2 Primary analysis showing the associations of frailty (three-categorical) with incident CVD and T2DM among long-term cancer survivors.

 FP_Frailty

  Non-frail

582/6598

7.7

Ref.

Ref.

  Pre-frail

654/6114

9.6

1.31 (1.17, 1.46)

1.18 (1.05, 1.32)

  Frail

144/676

21.3

2.97 (2.47, 3.57)

2.12 (1.73, 2.60)

  P for trend

—

—

<0.001

<0.001

  P for per 1-point increase

—

—

<0.001

<0.001

 FI_Frailty

  Non-frail

282/4247

5.7

Ref.

Ref.

  Pre-frail

753/7077

9.5

1.68 (1.46, 1.92)

1.51 (1.32, 1.74)

  Frail

345/2064

15.7

2.83 (2.42, 3.32)

2.19 (1.85, 2.59)

  P for trend

—

—

<0.001

<0.001

  P for per 0.1-point increase

—

—

<0.001

<0.001

 FP_Frailty

  Non-frail

62/3039

2.8

Ref.

Ref.

  Pre-frail

108/2755

5.4

2.05 (1.50, 2.80)

1.46 (1.04, 2.05)

  Frail

17/307

8.0

2.96 (1.73, 5.06)

1.29 (0.69, 2.39)

  P for trend

—

—

<0.001

0.084

  P for per 1-point increase

—

—

<0.001

0.083

 FI_Frailty

  Non-frail

22/1894

1.6

Ref.

Ref.

  Pre-frail

109/3249

4.6

2.89 (1.82, 4.59)

2.40 (1.51, 3.82)

  Frail

56/958

8.2

5.18 (3.15, 8.53)

3.09 (1.81, 5.26)

  P for trend

—

—

<0.001

<0.001

  P for per 0.1-point increase

—

—

<0.001

<0.001