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Fig. 3 | BMC Medicine

Fig. 3

From: Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p/Stat1 pathway

Fig. 3

The effects of MSCATV-EV and MSC-EV on macrophage polarization shifts in vitro. A PKH-67 labeled MSCATV-EV or MSC-EV (green) intake by rat BMDMs (red). B Western blot analysis for protein expressions of iNOS and Arg1 in BMDMs. C Quantification of iNOS and Arg1 expressions in B, n = 3 per group. D qPCR analysis for mRNA expressions of macrophage markers (M1: iNOS, IL-12, TNF-α; M2: Arg1, IL-10, CD206) in BMDMs described in B, n = 4 per group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Arg1, arginase 1; AMI, acute myocardial infarction; ATV, atorvastatin; BMDMs, bone marrow-derived macrophages; EV, extracellular vesicle; IL, interleukin; iNOS, inducible nitric oxide synthase; LPS, lipopolysaccharide; MSCs, mesenchymal stem cells; qPCR, quantitative polymerase chain reaction; TNF-α, tumor necrosis factor alpha

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BMC Medicine

ISSN: 1741-7015

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