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Fig. 7 | BMC Medicine

Fig. 7

From: Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p/Stat1 pathway

Fig. 7

Schematic summary of our main findings. Intramyocardial injection of rat bone marrow MSCATV-EV in border zone delivers the upregulated miR-139-3p into infiltrated macrophages and promotes M2 macrophage polarization by suppressing Stat1 expression and activation, facilitating cardiac repair after infarction. ATV, atorvastatin; EVs, extracellular vesicles; MSCs, mesenchymal stem cells; Stat1, signal transducer and activator of transcription 1

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