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Table 1 Baseline characteristics

From: The efficacy and safety of apatinib plus capecitabine in platinum-refractory metastatic and/or recurrent nasopharyngeal carcinoma: a prospective, phase II trial

Characteristic, n (%)

Intention-to-treat population (n = 64)

Gender

 Male

49 (76.6)

 Female

15 (23.4)

Age, median (IQR), years

44 (39–54)

Histology

 WHO I/II

8 (12.5)

 WHO III

56 (87.5)

ECOG performance status

 0

29 (45.3)

 1

19 (29.7)

 2

16 (25.0)

Recurrence and/ or metastasis

 Recurrence

5 (7.8)

 Metastasis

44 (68.8)

 Recurrence and metastasis

15 (23.4)

Involved metastatic organs

 Single

28 (43.8)

 Multiple

31 (48.4)

Location of metastases

 Liver

30 (46.9)

 Lung

26 (40.6)

 Bone

22 (34.4)

 Others

24 (37.5)

Target lesion size, median (IQR), mm

47 (33–79)

Plasma EBV DNA level, median (IQR), copies/mL

3915 (422–32,500)

No. of previous treatment

 1

38 (59.4)

 2

12 (18.8)

 ≥ 3

14 (21.9)

Previous PD-1/PD-L1 inhibitor treatment

 Yes

23 (35.9)

 No

41 (64.1)

  1. Abbreviations: ECOG, Eastern cooperative oncology group, EBV Epstein-Barr virus, PD-1, programmed cell death-1, PD-L1 Programmed cell death-ligand 1