Skip to main content
Fig. 6 | BMC Medicine

Fig. 6

From: NF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer

Fig. 6

Regulation of CRC progression by macrophage-specific Act1 knockdown. Macrophage-specific Act1 knockdown promoted adenocarcinoma transition through the recruitment of TAMs and CD8+ T cells in tumor tissues. By activating STAT3 transcription factors, macrophages-specific Act1knockdown crosstalk with CRC cells and CD8+ T cells via CXCL9/10-CXCR3 and PD-1/PD-L1 axis and consequently promoted epithelial-mesenchymal transition and CRC progression. (Figure was created with Biorender.com)

Back to article page

BMC Medicine

ISSN: 1741-7015

Contact us