Skip to main content
Fig. 1 | BMC Medicine

Fig. 1

From: Potential health and economic impact of paediatric vaccination using next-generation influenza vaccines in Kenya: a modelling study

Fig. 1

Modelling overview: A Methods overview, depicting inputs, models and outputs. B Model diagram, including both the epidemic and the vaccination model. Elements in solid green are included in both models. Transitions in grey are included only in the epidemic model, and transitions in dotted green are included only in the vaccination model. States are Susceptible (S), Exposed (E), Infectious (I) and Recovered (R), and their vaccinated counterparts (Sv, Ev1, Ev2, Iv1, Iv2, Rv). v denotes the vaccinated equivalent of the compartments. See Table S3 for parameter details. \(\updelta\) is the rate of vaccination in age group \(\mathrm{i}\), \(\mathrm{\alpha }\) is the efficacy by subtype (\(\mathrm{k}\)), \(\upomega\) is vaccine-derived immunity waning. The model is run separately for each subtype. For the epidemic model, in both vaccinated and unvaccinated compartments, susceptibles who are infected with the viral subtype enter the first Exposed (E) compartment. They then progress through the E and Infectious (I) compartments. After ceasing to be infectious they enter the R compartment, whereupon they cannot be re-infected during the same epidemic period. Both the E and I populations consist of two compartments, in order to get a gamma-distributed waiting time. Each compartment is also subdivided by age (i)

Back to article page