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Table 2 Independent genome-wide significant lead SNPs verified to be associated with PE

From: Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population

Chromosome position

rsID

EA/OA

Nearest gene

Discovery stage

Replication stage

Meta

    

EAF (case/control)

OR (95% CI)

P-value

EAF (case/control)

OR (95% CI)

P-value

OR (95% CI)

P-value

I2

4:120,241,902

rs1799883

T/C

FABP2

0.31 (0.39/0.31)

1.41 (1.25–1.59)

1.05 × 10−8

0.31 (0.39/0.30)

1.43 (1.28–1.61)

1.25 × 10−9

1.42 (1.31–1.54)

7.59 × 10−17

0

4:155,525,276

rs2066865

A/G

FGG

0.51 (0.57/0.52)

1.41 (1.25–1.58)

9.85 × 10−9

0.52 (0.55/0.52)

1.34 (1.20–1.50)

6.19 × 10−7

1.37 (1.26–1.49)

3.81 × 10−14

0

9:136,145,484

rs582094

T/A

ABO

0.43 (0.50/0.43)

1.29 (1.15–1.45)

2.25 × 10−5

0.44 (0.49/0.43)

1.33 (1.19–1.49)

1.18 × 10−6

1.31 (1.21–1.42)

1.16 × 10−10

0

  1. Chromosome position: based on hg19/GRCh37 build. rsID rs number, EA Effect allele, OA Other allele, EAF Effect allele frequency, OR Odds ratio, CI confidence interval