The impact of metabolic endotoxaemia on the browning process in human adipocytes

Table 2 Correlations between studied pro-inflammatory and brown adipose tissue (BAT) related genes

		IL6		MCP1		TNFα		IL1β
		Pearson’s r	P value	Pearson’s r	P value	Pearson’s r	P value	Pearson’s r	P value
CIDEA	Sc	-0.01	0.91	0.01	0.93	-0.05	0.55	0.03	0.78
CIDEA	Om	-0.33***	2.00E-04	-0.31***	6.00E-04	-0.12	0.21	-0.40****	7.25E-06
ELOVL3	Sc	-0.23**	0.01	-0.16	0.08	-0.06	0.52	-0.13	0.17
ELOVL3	Om	-0.33***	2.00E-04	-0.30***	7.00E-04	-0.05	0.62	-0.35***	1.00E-04
PLIN5	Sc	-0.20*	0.03	-0.05	0.58	-0.26**	3.00E-03	-0.16	0.08
PLIN5	Om	-0.26**	3.00E-03	-0.22*	0.02	-0.17	0.05	-0.23*	0.01
SLC27A2	Sc	0.07	0.47	0.004	0.96	-0.10	0.28	0.10	0.28
SLC27A2	Om	-0.13	0.19	-0.12	0.19	0.01	0.91	-0.29**	1.00E-03

The correlation of genes for interleukin-6 (IL6), monocyte chemotactic protein-1 (MCP1), tumour necrosis factor-alpha (TNFα), and interleukin-1beta (IL1β) with BAT-related genes, i.e. cell death-inducing DFFA-like effector A (CIDEA), ELOVL fatty acid elongase 3 (ELOVL3), perilipin 5 (PLIN5) and solute carrier family 27 member 2 (SLC27A2), was assessed using the Pearson correlation test. Significant correlations are highlighted in bold font, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

ISSN: 1741-7015