Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study

Fan, Jiayao; Zhou, Yuan; Meng, Ran; Tang, Jinsong; Zhu, Jiahao; Aldrich, Melinda C.; Cox, Nancy J.; Zhu, Yimin; Li, Yingjun; Zhou, Dan

doi:10.1186/s12916-023-02863-1

Table 2 Significant MR results of causal links between gut microbiome and smoking phenotypes by using IVW method and cML-MA method

From: Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study

Exposure	Outcome	No. SNP	Methods	β	SE	P_IVW	P_FDR	Horizontal pleiotropy P _{for Egger intercept}	Heterogeneity P _{for Cochran’s Q}
Phylum Actinobacteria	Age of initiation	6	IVW	0.051	0.019	7.74e-03	0.079	0.466	0.386
Phylum Actinobacteria		6	cML-MA	0.053	0.020	7.99e-3	0.082
Order Bifidobacteriales		7	IVW	0.050	0.016	1.73e-03	0.024	0.098	0.714
Order Bifidobacteriales		7	cML-MA	0.050	0.015	9.45e-4	0.013
Family Bifidobacteriaceae		7	IVW	0.050	0.016	1.73e-03	0.024	0.098	0.714
Family Bifidobacteriaceae		7	cML-MA	0.050	0.015	9.45e-4	0.013
Genus Bifidobacterium		7	IVW	0.049	0.016	1.79e-03	0.024	0.095	0.725
Genus Bifidobacterium		7	cML-MA	0.050	0.015	9.59e-4	0.013
Phylum Actinobacteria	Cigarettes per day	6	IVW	-0.066	0.024	5.31e-03	0.092	0.357	0.139
Phylum Actinobacteria		6	cML-MA	-0.063	0.021	3.28e-3	0.050
Class Actinobacteria		8	IVW	-0.053	0.018	3.70e-03	0.092	0.446	0.084
Class Actinobacteria		8	cML-MA	-0.050	0.016	1.93e-3	0.050
Order Bifidobacteriales		7	IVW	-0.048	0.019	1.12e-02	0.092	0.455	0.077
Order Bifidobacteriales		7	cML-MA	-0.043	0.017	9.67e-3	0.050
Family Bifidobacteriaceae		7	IVW	-0.048	0.019	1.12e-02	0.092	0.455	0.077
Family Bifidobacteriaceae		7	cML-MA	-0.043	0.017	9.67e-3	0.050
Genus Bifidobacterium		7	IVW	-0.048	0.018	8.83e-03	0.092	0.552	0.074
Genus Bifidobacterium		7	cML-MA	-0.043	0.016	7.69e-3	0.050
Phylum Actinobacteria	Lifetime smoking	6	IVW	-0.023	0.009	8.43e-03	0.056	0.398	0.803
Phylum Actinobacteria		6	cML-MA	-0.02	0.009	9.09e-3	0.042
Class Actinobacteria		7	IVW	-0.019	0.007	5.79e-03	0.056	0.770	0.469
Class Actinobacteria		7	cML-MA	-0.019	0.007	6.00e-3	0.042
Order Bifidobacteriales		6	IVW	-0.023	0.008	5.32e-03	0.056	0.468	0.152
Order Bifidobacteriales		6	cML-MA	-0.024	0.007	7.71e-4	0.012
Family Bifidobacteriaceae		6	IVW	-0.023	0.008	5.32e-03	0.056	0.468	0.152
Family Bifidobacteriaceae		6	cML-MA	-0.024	0.007	7.71e-4	0.012
Genus Bifidobacterium		6	IVW	-0.023	0.008	7.00e-03	0.056	0.385	0.161
Genus Bifidobacterium		6	cML-MA	-0.023	0.007	9.08e-4	0.012
Genus Peptococcus		4	IVW	-0.019	0.007	7.30e-03	0.056	0.371	0.540
Genus Peptococcus		4	cML-MA	-0.019	0.007	9.49e-3	0.042
Age of initiation	Genus Eisenbergiella	24	IVW	-1.062	0.250	2.21e-05	0.005	0.476	0.320
	Genus Eisenbergiella	24	cML-MA	-1.101	0.248	8.77e-06	0.002
	Genus Lactococcus	23	IVW	1.135	0.317	3.45e-04	0.036	0.222	0.241
	Genus Lactococcus	23	cML-MA	1.188	0.297	6.39e-05	0.007
Smoking initiation	Order Pasteurellales	287	IVW	-0.328	0.097	7.40e-04	0.039	0.797	0.725
	Order Pasteurellales	287	cML-MA	-0.344	0.099	5.42e-4	0.023
	Family Pasteurellaceae	287	IVW	-0.328	0.097	7.40e-04	0.039	0.797	0.533
	Family Pasteurellaceae	287	cML-MA	-0.344	0.099	5.42e-4	0.023
	Family Christensenellaceae	291	IVW	-0.278	0.072	1.18e-04	0.025	0.103	0.725
	Family Christensenellaceae	291	cML-MA	-0.284	0.074	1.35e-4	0.023
	Genus ChristensenellaceaeR	291	IVW	-0.267	0.073	2.75e-04	0.029	0.068	0.775
	Genus ChristensenellaceaeR	291	cML-MA	-0.272	0.075	3.22e-4	0.023
	Genus Haemophilus	287	IVW	-0.321	0.099	1.15e-03	0.041	0.554	0.827
	Genus Haemophilus	287	cML-MA	-0.339	0.101	7.91e-4	0.028
	Genus Intestinimonas	290	IVW	0.265	0.090	3.15e-03	0.095	0.801	0.110
	Genus Intestinimonas	290	cML-MA	0.273	0.088	1.90e-3	0.057
	Genus Romboutsia	290	IVW	-0.279	0.085	1.06e-03	0.041	0.611	0.026
	Genus Romboutsia	290	cML-MA	-0.294	0.081	2.84e-4	0.023
Lifetime smoking	Class Coriobacteriia	372	IVW	0.242	0.069	4.72e-04	0.020	0.241	0.971
	Class Coriobacteriia	372	cML-MA	0.248	0.070	3.98e-4	0.016
	Order Coriobacteriales	372	IVW	0.242	0.069	4.72e-04	0.020	0.241	0.971
	Order Coriobacteriales	372	cML-MA	0.248	0.070	3.98e-4	0.016
	Family Coriobacteriaceae	372	IVW	0.242	0.069	4.72e-04	0.020	0.241	0.971
	Family Coriobacteriaceae	372	cML-MA	0.248	0.070	3.98e-4	0.016
	Genus Catenibacterium	328	IVW	0.505	0.170	2.98e-03	0.090	0.333	0.478
	Genus Catenibacterium	328	cML-MA	0.516	0.173	2.80e-3	0.085
	Genus RuminococcaceaeNK4A214	371	IVW	-0.261	0.074	4.48e-04	0.020	0.996	0.513
	Genus RuminococcaceaeNK4A214	371	cML-MA	-0.266	0.076	4.67e-4	0.016
	Genus RuminococcaceaeUCG005	371	IVW	-0.237	0.076	1.91e-03	0.067	0.887	0.072
	Genus RuminococcaceaeUCG005	371	cML-MA	-0.269	0.074	3.05e-4	0.016
	Genus Eubacterium xylanophilum	370	IVW	-0.308	0.080	1.08e-04	0.020	0.035	0.802
	Genus Eubacterium xylanophilum	370	cML-MA	-0.317	0.081	8.94e-05	0.016

MR Mendelian randomization, IVW inverse-variance weighted, cML-MA constrained maximum likelihood and model averaging-based MR method, No.SNP number of single-nucleotide polymorphism (SNP), SE standard error, P_FDR P-value corrected by false discovery rate (FDR) across tested taxa

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ISSN: 1741-7015

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