CNS response | Groups | |||
---|---|---|---|---|
40 mg orally once daily (n = 1) | 80 mg orally once daily (n = 34) | 160 mg orally once daily (n = 13) | 240 mg orally once daily (n = 4) | |
CR, n (%) | 0 | 1 (3) | 1 (8) | 0 |
PR, n (%) | 0 | 21 (62) | 10 (77) | 1 (25) |
SD, n (%) | 0 | 11 (32) | 2 (15) | 3 (75) |
PD, n (%) | 1 (100) | 0 | 0 | 0 |
NE, n (%) | 0 | 1 (3) | 0 | 0 |
CNS-ORR (95%CI) | 0 | 65% (47–80%) | 85% (55–98%) | 25% (1–81%) |
CNS-DCR (95%CI) | 0 | 97% (85–100%) | 100% | 100% |