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Fig. 5 | BMC Medicine

Fig. 5

From: Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability

Fig. 5

Relationship between IL-1β and MDSCs or CD8+ T cells in MSI-H/dMMR CRC patients. A IHC staining for IL-1β in CRC tissues. B Proportion of IL-1β-positive and IL-1β-negative tissues in the sensitive and resistant groups. C IHC staining for MMP9 in IL-1β-positive and -negative groups. D Correlation between MMP9 and IL-1β according to IHC scores. IF examination and quantification of (E) PMN-MDSCs, (F) M-MDSCs, and (G) CD8+ T cells in the IL-1β-negative and -positive groups. Pearson correlation analysis of IF scores between IL-1β and (H) PMN-MDSCs, (I) M-MDSCs, and (J) CD8.+ T cells. ****P < 0.0001

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BMC Medicine

ISSN: 1741-7015

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