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Fig. 3 | BMC Medicine

Fig. 3

From: Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study

Fig. 3

Mendelian randomization analysis considering effects through blood pressure. A The association of genome-wide and NPR3-predicted height with SBP and DBP. B The association of genome-wide and NPR3-predicted SBP reduction on CVD risk. Effect estimates are interpreted as standard deviation (SD) difference per 1-SD greater height (~ 9.2 cm) for A, and difference in disease odds per 1-SD lower SBP (19.4 mmHg) for B. An asterisk denotes p < .05. CAD, coronary artery disease; CI, confidence interval; CVD, cardiovascular disease (reflects a pooled CAD, heart failure and stroke effect estimate); NPR3, natriuretic peptide receptor 3; SBP, systolic blood pressure

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BMC Medicine

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