Fig. 3

Medical complaints for individuals 45 years or older. Solid lines show the cumulative incidence of visiting the general practitioner or emergency ward with common complaints for up to 90 days after a (hypothetical) date of third dose of mRNA vaccines, per 100,000 individuals for individuals 45 years or older. Red curve shows individuals with three doses (three-dose group) and blue curve shows the control group consisting of individuals without three doses. Shaded areas show 95% confidence intervals. Dashed lines show the cumulative incidence of competing risks. Competing risk includes death and hospitalization for the six main outcomes, only death for positive tests and COVID-19 hospitalizations, and no competing risk for all-cause mortality. Dashed vertical line represents day 7, prior to which no vaccine effectiveness can be expected