Fig. 2

Local genetic correlation between depression and breast cancer. Red bars in Manhattan plots and red dots in QQ plots represent loci showing significant local genetic correlation with ρ-HESS after multiple testing adjustments (P < 0.05/1,703). Blue bars in Manhattan plots and blue dots in QQ plots represent additional loci showing a high probability of shared associations using GWAS-PW (PPA _3 > 0.5). a Manhattan plot showing the local genetic correlation, genetic covariance, and SNP-heritability estimated from ρ-HESS between depression and overall breast cancer. b QQ plot presenting region-specific P-values for ρ-HESS-estimated local genetic correlation between depression and overall breast cancer. c Manhattan plot showing the local genetic correlation, genetic covariance, and SNP-heritability estimated from ρ-HESS between depression and ER + breast cancer. d QQ plot presenting region-specific P-values for ρ-HESS-estimated local genetic correlation between depression and ER + breast cancer. DEP: depression; BC: breast cancer; ER: estrogen receptor