Investigating the relationship between depression and breast cancer: observational and genetic analyses

Table 1 Observational association between depression and breast cancer

Depression status during following up	Breast cancer cases/person years	Model 1	Model 2	Model 3
No	9,516/2,912,715	1.000 (ref)	1.000 (ref)	1.000 (ref)
Yes	529/101,453	1.075 (0.963–1.199)	1.090 (0.951–1.250)	1.096 (0.951–1.264)

Model 1: adjusted for age, assessment center, and the top 40 genetic principal components
Model 2: adjusted for age, assessment center, the top 40 genetic principal components, income, Townsend deprivation index, body mass index, smoking, drinking, physical activity (IPAQ), sleep duration, and education
Model 3: adjusted for age, assessment center, the top 40 genetic principal components, income, Townsend deprivation index, body mass index, smoking, drinking, physical activity (IPAQ), sleep duration, education, family history of breast cancer, parity, age at menarche, menopausal status, use of oral contraceptives, hormone replacement therapy, diagnosis of other mental health disorders (i.e., bipolar disorder, multiple personality disorder, or schizophrenia/psychosis), and treatment/medication for antidepressants or antipsychotics

ISSN: 1741-7015