Table 3 Genome-wide significant loci shared between depression and breast cancer in cross-trait meta-analysis (PCPASSOC < 5 × 10–8 and Psingle-trait < 1 × 10–3)
SNP | CHR:Position | A1 | A2 | BETA | Psingle-trait | PCPASSOC | Linear closest genea | Interacting geneb | ||
|---|---|---|---|---|---|---|---|---|---|---|
BC | Depression | BC | Depression | |||||||
Depression and overall breast cancer | ||||||||||
rs78955704 | chr5:45072777-45968819 | A | T | 0.10 | 0.04 | 3.57×10-10 | 4.72×10-04 | 1.29×10-09 | HCN1 | .. |
rs68006638 | chr6:25219582-26090025 | A | G | -0.06 | -0.04 | 4.98×10-07 | 2.13×10-08 | 1.44×10-12 | .. | .. |
rs35400317 | chr6:26095643-27091661 | T | C | -0.06 | -0.05 | 5.35×10-08 | 3.87×10-14 | 1.41×10-19 | ABT1 | BTN3A2 and other 11 |
rs35768595 | chr6:27103654-27626631 | T | C | -0.06 | -0.05 | 1.45×10-07 | 8.21×10-14 | 8.42×10-19 | .. | ZNF184 and other 30 |
rs17693963 | chr6:27219491-28173219 | A | C | 0.05 | 0.06 | 2.21×10-06 | 2.31×10-16 | 8.96×10-21 | RP1-97D16.1 | PRSS16 and other 44 |
rs67981811 | chr6:27854963-28411941 | C | G | 0.06 | 0.06 | 4.17×10-07 | 1.14×10-18 | 6.52×10-24 | ZSCAN12 | .. |
rs9263717 | chr6:31078804-31321919 | A | G | -0.03 | -0.02 | 3.64×10-06 | 2.32×10-05 | 1.92×10-08 | PSORS1C1, CR753819.4, BX927139.2, CR938714.1 | DDR1 and other 19 |
rs56101042 | chr14:103229696-103387971 | A | G | 0.03 | -0.03 | 9.58×10-04 | 5.06×10-07 | 6.53×10-09 | TRAF3, snoU13 | TRAF3 and other 4 |
rs4906340 | chr14:103833385-104174123 | A | G | -0.02 | -0.03 | 3.37×10-04 | 1.06×10-09 | 4.22×10-12 | RP11-73ƒM18.2, APOPT1, KLC1 | KLC1 and other 2 |
rs2403907 | chr21:16488615-16578800 | A | C | -0.08 | 0.02 | 1.38×10-33 | 6.19×10-04 | 1.55×10-33 | .. | .. |
rs5762586 | chr22:28540492-29090363 | A | T | -0.04 | -0.01 | 3.88×10-09 | 5.40×10-04 | 1.43×10-08 | TTC28 | .. |
rs5757946 | chr22:40809034-40809034 | A | G | -0.04 | -0.02 | 3.77×10-12 | 4.05×10-04 | 1.28×10-11 | SGSM3, MKL1, RP5-1042K10.13 | MKL1 and other 1 |
Depression and ER+ breast cancer | ||||||||||
rs13198474 | chr6:25419094-26090025 | A | G | -0.08 | -0.04 | 2.68×10-07 | 2.93×10-08 | 2.30×10-11 | SLC17A3 | .. |
rs45527431 | chr6:26111271-27091661 | A | G | 0.08 | 0.05 | 6.74×10-08 | 3.83×10-14 | 3.92×10-18 | ABT1 | BTN3A2 and other 11 |
rs35768595 | chr6:27103654-27626631 | T | C | -0.08 | -0.05 | 7.16×10-08 | 8.21×10-14 | 1.38×10-17 | .. | .. |
rs17693963 | chr6:27219491-28173219 | A | C | 0.08 | 0.06 | 2.95×10-08 | 2.31×10-16 | 8.85×10-21 | RP1-97D16.1 | PRSS16 and other 44 |
rs67981811 | chr6:27854963-28411941 | C | G | 0.08 | 0.06 | 4.40×10-08 | 1.14×10-18 | 3.14×10-23 | ZSCAN12 | .. |
rs7847927 | chr9:110297639-110333432 | C | G | 0.07 | -0.02 | 3.62×10-20 | 5.47×10-04 | 3.12×10-19 | RP11-438P9.2 | .. |
rs10843109 | chr12:28288716-2857324 | T | C | -0.08 | 0.03 | 1.60×10-09 | 5.10×10-04 | 8.32×10-09 | CCDC91 | .. |
rs1343607 | chr13:53617781-54049489 | A | G | -0.03 | 0.02 | 8.33×10-04 | 1.07×10-07 | 3.31×10-09 | .. | OLFM4 |
rs2403907 | chr21:16488615-16582933 | A | C | -0.10 | 0.02 | 2.95×10-33 | 6.19×10-04 | 1.91×10-32 | .. | .. |