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Table 4 Significant shared transcriptome-wide association analysis results between depression and breast cancer

From: Investigating the relationship between depression and breast cancer: observational and genetic analyses

Tissue

Ensembl gene ID

Gene symbol

CHR

BC

Depression

Best.GWAS.ID

TWAS.Z

PBonferroni

Best.GWAS.ID

TWAS.Z

PBonferroni

Depression and overall breast cancer

 Whole Blood

ENSG00000137312.14

FLOT1

6

rs3130975

-4.66

2.56 × 10–02

rs3130557

-6.15

6.10 × 10–06

 Uterus

ENSG00000225851.1

HLA-S

6

rs3130975

4.30

4.07 × 10–02

rs3130557

4.84

3.07 × 10–03

 Artery Coronary

ENSG00000247934.4

.

12

rs7297051

7.41

4.87 × 10–10

rs11049301

-4.44

3.48 × 10–02

 Brain Cerebellum

ENSG00000168612.4

ZSWIM1

20

rs3746506

-4.60

3.15 × 10–02

rs9074

4.83

9.79 × 10–03

 Heart Left Ventricle

ENSG00000100351.16

GRAP2

22

rs17001868

-4.87

6.69 × 10–03

rs139915

-4.50

3.93 × 10–02

Depression and ER + breast cancer

 Colon Transverse

ENSG00000137312.14

FLOT1

6

rs3130975

-4.49

4.68 × 10–02

rs3130557

-7.49

4.31 × 10–10

 Artery Coronary

ENSG00000247934.4

.

12

rs7297051

5.50

1.49 × 10–04

rs11049301

-4.44

3.48 × 10–02

  1. All these loci were TWAS significant (PBonferroni < 0.05) for both depression and breast cancer in at least one GTEx tissues
  2. TWAS Transcriptome-wide association studies, CHR Chromosome, Best.GWAS.ID rsID of the most significant GWAS SNP in locus, TWAS.Z TWAS Z-score, BC Breast cancer, ER Estrogen receptor