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Fig. 2 | BMC Medicine

Fig. 2

From: Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study

Fig. 2

Meta-analysis of six intestinal gene expression datasets between patients with CD and HCs. A In total, 708 out of 817 genes presented in all six intestinal transcriptome data were assessed for expression differences between patients with CD and HCs. The volcano plot shows the meta effect sizes on the x-axis while the y-axis indicates the − log10-transformed meta P values. Red dots are the 438 significant differentially expressed genes (DEGs), and gray dots represent non-significantly expressed genes. The dashed line indicates the significant threshold with FDR < 0.05 corrected for the number of gene tests. B Cell type-Specific Enrichment Analysis DataBase was used to investigate whether the intestinal DEGs were specific to any cell type in the small intestine and colon. The x-axis indicates the cell types derived from the intestinal tissue and blood. Dots represent 77 small intestine and colon cell types annotated by 23 general classifications descending by order of significance. The dashed line is the significant threshold with FDR < 0.05

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