Skip to main content
Fig. 3 | BMC Medicine

Fig. 3

From: Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study

Fig. 3

Three-step SMR analysis prioritized putative causal OS genes and mechanisms in CD using blood tissue. Examples of well-known and novel CD-causal OS genes. A, C Locus zoom plots showing the consistent genetic effects from CD GWAS, cis-mQTL, and cis-eQTL nearby STAT3 and GPX3 (from upper to lower panels, all minimum P < 1 × 10−5). B, D Three-step SMR indicating significant causal relationships between gene expressions and CD onset mediated by methylation (all three-step SMR FDR < 0.05, HEIDI test P > 0.05). From left to right: SMR between gene expression and CD GWAS, SMR between gene methylation and CD GWAS, and SMR between gene methylation and expression

Back to article page