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Fig. 5 | BMC Medicine

Fig. 5

From: Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study

Fig. 5

External cohort validation. First Affiliated Hospital of Sun Yat-sen University (FAH-SYS) cohort with both intestinal bulk RNA-seq and fecal metagenomics data included in validation analysis. A A total of 388 out of 437 (88.79%) differentially expressed genes (DEGs) identified from the meta-analysis show consistent changes between patients with CD and HCs (Spearman rank’s correlation coefficient r s = 0.84, P = 2.2 × 10−23). The x- and y-axes indicate the Z score estimated from the meta-analysis and FAH-SYS cohort, respectively. Yellow dots represent the 388 consistent DEGs, while gray dots are non-validated. B–D Validation of DEGs, pathway-related taxa, and the association between taxa and gene expressions, respectively (from left to right). The upper to lower panels are for the MUC1, PRKAB1, and CD40 genes, respectively. The taxa probably involved in PWY.7237, P164.PWY, and PWY.5101 were selected from MetaCyc database annotation

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BMC Medicine

ISSN: 1741-7015

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