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Fig. 5 | BMC Medicine

Fig. 5

From: Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites

Fig. 5

Gene set enrichment analysis and pathologic tissue section revealed potential ability of MK-7-regulated microbiota on modulating host energy metabolism and immunoinflammation. A Overview of the difference of gene expression (P < 0.05 and │log2fold change│ > 1) in liver, colon and pancreas tissue between the VKR group and HFABX or NCR group. B Top 15 significantly altered KEGG pathways (P < 0.05) caused by MK-7-regulated microbiota under whole gene set enrichment analysis of the liver, colon, and pancreas tissue, respectively. C Liver, pancreas, and colon histopathologic appearance by HE and PAS staining. Scale bars, 100 μm of liver and colon, and 200 μm of pancreas

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