Fig. 9

Csk serves as a critical downstream target of Adipsin. A Schematic illustration of adeno-associated virus 9 delivery leading to knockdown of Csk in CMECs. B Representative immunofluorescence images of Csk in cardiac tissue. Scale bar = 20 μm. C Quantitative analysis of Csk fluorescence intensity in B. D Representative scanning electron micrographs of cardiac microvessels corrosion in different groups. Inserted boxes indicated areas of magnification shown below. Scale bar = 10 μm (upper) and 5 μm (bottom). E Representative transmission electron micrographs of microvascular leakage of lanthanum nitrate evaluating endothelial permeability. Inserted boxes indicated areas of magnification shown below, and red arrowheads indicated areas of lanthanum nitrate deposition. Scale bar = 1 μm (upper) and 1 μm (bottom). Data were presented as mean ± SEM. Student’s t‐test was used for statistical analysis