Fig. 4

Progression of clinical response measured by AUC C-peptide from MMTT (A) and daily insulin consumption (B). Data are shown for the intent-to-treat population. Central lines represent median values, boxes represent interquartile range, and whiskers represent upper and lower 1.5 × interquartile range, respectively. Dose A: 50 μg at Week 0 followed by 3 × 25 μg; dose B: 150 μg at Week 0 followed by 3 × 75 μg; dose C: 450 μg at Week 0 followed by 3 × 225 μg. Normalized AUC refers to C-peptide normalized to glucose. All plotted data are biological replicates. Points represent subjects. AUC, area under the curve; MMTT, Mixed Meal Tolerance Test