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  1. Elective surgeries can be associated with significant harm to older adults. The present study aimed to identify the prognostic factors associated with the development of postoperative complications among older...

    Authors: Jennifer Watt, Andrea C. Tricco, Catherine Talbot-Hamon, Ba’ Pham, Patricia Rios, Agnes Grudniewicz, Camilla Wong, Douglas Sinclair and Sharon E. Straus
    Citation: BMC Medicine 2018 16:2
  2. The use of cardiovascular medication for the primary prevention of cardiovascular disease (CVD) is potentially inappropriate when potential risks outweigh the potential benefits. It is unknown whether deprescr...

    Authors: Clare H. Luymes, Rosalinde K. E. Poortvliet, Nan van Geloven, Margot W. M. de Waal, Yvonne M. Drewes, Jeanet W. Blom, Nynke Smidt, Willem J. J. Assendelft, Wilbert B. van den Hout, Wouter de Ruijter and Mattijs E. Numans
    Citation: BMC Medicine 2018 16:5
  3. Glucocorticoids are associated with increased fracture risk and are the mainstay of treatment in polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). However, fracture risk in these conditions has not ...

    Authors: Zoe Paskins, Rebecca Whittle, Alyshah Abdul Sultan, Sara Muller, Milica Blagojevic-Bucknall, Toby Helliwell, Samantha Hider, Edward Roddy and Christian Mallen
    Citation: BMC Medicine 2018 16:4
  4. Epidemiological studies suggest that reduced exposure to varicella might lead to an increased risk for herpes zoster (HZ). Reduction of exposure to varicella is a consequence of varicella vaccination but also ...

    Authors: Johannes Horn, Oliver Damm, Wolfgang Greiner, Hartmut Hengel, Mirjam E. Kretzschmar, Anette Siedler, Bernhard Ultsch, Felix Weidemann, Ole Wichmann, André Karch and Rafael T. Mikolajczyk
    Citation: BMC Medicine 2018 16:3
  5. Changes in climate, in conjunction with other drivers of mobility, shape human migration. While there is an increasing focus on the adaptive potential of migration, the health impacts of climate-related migrat...

    Authors: Patricia Schwerdtle, Kathryn Bowen and Celia McMichael
    Citation: BMC Medicine 2018 16:1
  6. Interventions in infectious diseases can have both direct effects on individuals who receive the intervention as well as indirect effects in the population. In addition, intervention combinations can have comp...

    Authors: M. Elizabeth Halloran, Kari Auranen, Sarah Baird, Nicole E. Basta, Steven E. Bellan, Ron Brookmeyer, Ben S. Cooper, Victor DeGruttola, James P. Hughes, Justin Lessler, Eric T. Lofgren, Ira M. Longini, Jukka-Pekka Onnela, Berk Özler, George R. Seage, Thomas A. Smith…
    Citation: BMC Medicine 2017 15:223
  7. To achieve complete polio eradication, the live oral poliovirus vaccine (OPV) currently used must be phased out after the end of wild poliovirus transmission. However, poorly understood threats may arise when ...

    Authors: James S. Koopman
    Citation: BMC Medicine 2017 15:221

    The original article was published in BMC Medicine 2017 15:180

    The original article was published in BMC Medicine 2017 15:175

  8. The UK, like many high-income countries, is experiencing a worsening shortfall of general practitioners (GPs) alongside an increasing demand for their services. At the same time, factors influencing junior doc...

    Authors: Thomas C. E. Gale, Paul J. Lambe and Martin J. Roberts
    Citation: BMC Medicine 2017 15:220
  9. Circulating concentrations of lipid biomarkers are associated with risk of cardiovascular diseases (CVD). The evidence for a relationship with cancer risk, however, is not entirely consistent. This study aims ...

    Authors: Verena Andrea Katzke, Disorn Sookthai, Theron Johnson, Tilman Kühn and Rudolf Kaaks
    Citation: BMC Medicine 2017 15:218
  10. HCV treatment uptake has drastically increased in HIV-HCV coinfected patients in France since direct-acting antiviral (DAA) treatment approval, resulting in HCV cure in 63% of all HIV-HCV patients by the end o...

    Authors: Victor Virlogeux, Fabien Zoulim, Pascal Pugliese, Isabelle Poizot-Martin, Marc-Antoine Valantin, Lise Cuzin, Jacques Reynes, Eric Billaud, Thomas Huleux, Firouze Bani-Sadr, David Rey, Anne Frésard, Christine Jacomet, Claudine Duvivier, Antoine Cheret, Laurent Hustache-Mathieu…
    Citation: BMC Medicine 2017 15:217
  11. Major depressive disorder (MDD) is often handled as an episodic and isolated disorder, resulting in an optimistic view about its prognosis. Herein, we test the idea that the prognosis of MDD changes if we vary...

    Authors: Judith Verduijn, Josine E. Verhoeven, Yuri Milaneschi, Robert A. Schoevers, Albert M. van Hemert, Aartjan T. F. Beekman and Brenda W. J. H. Penninx
    Citation: BMC Medicine 2017 15:215
  12. Populations exposed to humanitarian emergencies are particularly vulnerable to mental health problems, including new onset, relapse and deterioration of psychotic disorders. Inadequate care for this group may ...

    Authors: Giovanni Ostuzzi, Corrado Barbui, Charlotte Hanlon, Sudipto Chatterjee, Julian Eaton, Lynne Jones, Derrick Silove and Peter Ventevogel
    Citation: BMC Medicine 2017 15:197
  13. This Commentary describes the situation and healthcare needs of Afghans returning to their country of origin. With more than 600,000 Afghans returned from Pakistan and approximately 450,000 Afghans returned fr...

    Authors: Ariel Higgins-Steele, David Lai, Paata Chikvaidze, Khaksar Yousufi, Zelaikha Anwari, Richard Peeperkorn and Karen Edmond
    Citation: BMC Medicine 2017 15:196
  14. Chronic hepatitis B virus (HBV) infection leads to liver fibrosis, which is a major risk factor in hepatocellular carcinoma (HCC) and an independent risk factor of recurrence after HCC tumor resection. The HBV...

    Authors: Seungyeul Yoo, Wenhui Wang, Qin Wang, M Isabel Fiel, Eunjee Lee, Spiros P. Hiotis and Jun Zhu
    Citation: BMC Medicine 2017 15:214
  15. Diagnosis of monogenic as well as atypical forms of diabetes mellitus has important clinical implications for their specific diagnosis, prognosis, and targeted treatment. Single gene mutations that affect beta...

    Authors: Vikas Bansal, Johann Gassenhuber, Tierney Phillips, Glenn Oliveira, Rebecca Harbaugh, Nikki Villarasa, Eric J. Topol, Thomas Seufferlein and Bernhard O. Boehm
    Citation: BMC Medicine 2017 15:213

    The Commentary to this article has been published in BMC Medicine 2018 16:25

  16. Epigenomes are tissue specific and thus the choice of surrogate tissue can play a critical role in interpreting neonatal epigenome-wide association studies (EWAS) and in their extrapolation to target tissue. T...

    Authors: Xinyi Lin, Ai Ling Teh, Li Chen, Ives Yubin Lim, Pei Fang Tan, Julia L. MacIsaac, Alexander M. Morin, Fabian Yap, Kok Hian Tan, Seang Mei Saw, Yung Seng Lee, Joanna D. Holbrook, Keith M. Godfrey, Michael J. Meaney, Michael S. Kobor, Yap Seng Chong…
    Citation: BMC Medicine 2017 15:211
  17. Inflammation occurs as an immediate protective response of the immune system to a harmful stimulus, whether locally confined or systemic. In contrast, a persisting, i.e., chronic, inflammatory state, even at a...

    Authors: Maik Pietzner, Anne Kaul, Ann-Kristin Henning, Gabi Kastenmüller, Anna Artati, Markus M. Lerch, Jerzy Adamski, Matthias Nauck and Nele Friedrich
    Citation: BMC Medicine 2017 15:210
  18. Depression in tuberculosis increases the risk for adverse health outcomes. However, little is known about comorbid depression and tuberculosis in the general population. Thus, we assessed the association betwe...

    Authors: Ai Koyanagi, Davy Vancampfort, André F. Carvalho, Jordan E. DeVylder, Josep Maria Haro, Damiano Pizzol, Nicola Veronese and Brendon Stubbs
    Citation: BMC Medicine 2017 15:209
  19. Fiscal interventions are promising strategies to improve diets, reduce cardiovascular disease and diabetes (cardiometabolic diseases; CMD), and address health disparities. The aim of this study is to estimate ...

    Authors: José L. Peñalvo, Frederick Cudhea, Renata Micha, Colin D. Rehm, Ashkan Afshin, Laurie Whitsel, Parke Wilde, Tom Gaziano, Jonathan Pearson-Stuttard, Martin O’Flaherty, Simon Capewell and Dariush Mozaffarian
    Citation: BMC Medicine 2017 15:208
  20. Tuberculosis kills more people than any other infectious disease, and new regimens are essential. The primary endpoint for confirmatory phase III trials for new regimens is a composite outcome that includes ba...

    Authors: Patrick P. J. Phillips, Carl M. Mendel, Andrew J. Nunn, Timothy D. McHugh, Angela M. Crook, Robert Hunt, Anna Bateson and Stephen H. Gillespie
    Citation: BMC Medicine 2017 15:207
  21. Provision of routine iron supplements to prevent anaemia could increase the risk for lower genital tract infections as virulence of some pathogens depends on iron availability. This trial in Burkina Faso asses...

    Authors: Loretta Brabin, Stephen A. Roberts, Sabine Gies, Andrew Nelson, Salou Diallo, Christopher J. Stewart, Adama Kazienga, Julia Birtles, Sayouba Ouedraogo, Yves Claeys, Halidou Tinto, Umberto d’Alessandro, E. Brian Faragher and Bernard Brabin
    Citation: BMC Medicine 2017 15:206
  22. Telomere attrition is extremely rapid during the first years of life, while lifestyle during adulthood exerts a minor impact. This suggests that early life is an important period in the determination of telome...

    Authors: Esmée M. Bijnens, Maurice P. Zeegers, Catherine Derom, Dries S. Martens, Marij Gielen, Geja J. Hageman, Michelle Plusquin, Evert Thiery, Robert Vlietinck and Tim S. Nawrot
    Citation: BMC Medicine 2017 15:205
  23. Direct-acting antivirals (DAAs) have revolutionized chronic hepatitis C (HCV) treatment, but real-world effectiveness among vulnerable populations, including uninsured patients, is lacking. This study was cond...

    Authors: Christina Yek, Carolina de la Flor, John Marshall, Cindy Zoellner, Grace Thompson, Lisa Quirk, Christian Mayorga, Barbara J. Turner, Amit G. Singal and Mamta K. Jain
    Citation: BMC Medicine 2017 15:204
  24. Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with meta...

    Authors: Ju-Sheng Zheng, Stephen J. Sharp, Fumiaki Imamura, Albert Koulman, Matthias B. Schulze, Zheng Ye, Jules Griffin, Marcela Guevara, José María Huerta, Janine Kröger, Ivonne Sluijs, Antonio Agudo, Aurelio Barricarte, Heiner Boeing, Sandra Colorado-Yohar, Courtney Dow…
    Citation: BMC Medicine 2017 15:203
  25. The UK is dependent on international doctors, with a greater proportion of non-UK qualified doctors working in its universal health care system than in any other European country, except Ireland and Norway. Th...

    Authors: Aneez Esmail, Maria Panagioti and Evangelos Kontopantelis
    Citation: BMC Medicine 2017 15:191
  26. Dietary assessment is complex, and strategies to select the most appropriate dietary assessment tool (DAT) in epidemiological research are needed. The DIETary Assessment Tool NETwork (DIET@NET) aimed to establ...

    Authors: Janet E. Cade, Marisol Warthon-Medina, Salwa Albar, Nisreen A. Alwan, Andrew Ness, Mark Roe, Petra A. Wark, Katharine Greathead, Victoria J. Burley, Paul Finglas, Laura Johnson, Polly Page, Katharine Roberts, Toni Steer, Jozef Hooson, Darren C. Greenwood…
    Citation: BMC Medicine 2017 15:202
  27. Childhood pneumonia is the leading infectious cause of mortality in children younger than 5 years old. Recent updates to World Health Organization pneumonia guidelines recommend outpatient care for a populatio...

    Authors: Timothy Tuti, Ambrose Agweyu, Paul Mwaniki, Niels Peek and Mike English
    Citation: BMC Medicine 2017 15:201

    The Correction to this article has been published in BMC Medicine 2017 15:212

  28. While the United States has the largest number of children with type 1 diabetes mellitus, less is known regarding adult-onset disease. The present study utilizes nationwide data to compare the incidence of typ...

    Authors: Mary A. M. Rogers, Catherine Kim, Tanima Banerjee and Joyce M. Lee
    Citation: BMC Medicine 2017 15:199
  29. Obesity is common in young women, increasing insulin resistance (IR) and worsening pregnancy complications, including gestational diabetes (GDM). Women with polycystic ovary syndrome (PCOS) are commonly obese,...

    Authors: Nadira Sultana Kakoly, Arul Earnest, Lisa J. Moran, Helena J. Teede and Anju E. Joham
    Citation: BMC Medicine 2017 15:195
  30. All obese pregnant women are considered at equal high risk with respect to complications in pregnancy and birth, and are commonly managed through resource-intensive care pathways. However, the identification o...

    Authors: Matias C. Vieira, Sara L. White, Nashita Patel, Paul T. Seed, Annette L. Briley, Jane Sandall, Paul Welsh, Naveed Sattar, Scott M. Nelson, Debbie A. Lawlor, Lucilla Poston and Dharmintra Pasupathy
    Citation: BMC Medicine 2017 15:194
  31. HIV-associated immune defects inhibit tuberculosis (TB) diagnosis, promote development of extrapulmonary TB and paucibacillary pulmonary TB cases with atypical radiographic features, and increase TB relapse ra...

    Authors: Jia Fan, Hedong Zhang, Duc T. Nguyen, Christopher J. Lyon, Charles D. Mitchell, Zhen Zhao, Edward A. Graviss and Ye Hu
    Citation: BMC Medicine 2017 15:188
  32. Docetaxel, pemetrexed, erlotinib, and gefitinib are recommended as second-line treatment for advanced non-small cell lung cancer (NSCLC) with wild-type or unknown status for epidermal growth factor receptor (E...

    Authors: Perrine Créquit, Anna Chaimani, Amélie Yavchitz, Nassima Attiche, Jacques Cadranel, Ludovic Trinquart and Philippe Ravaud
    Citation: BMC Medicine 2017 15:193

    The Commentary to this article has been published in BMC Medicine 2018 16:24

  33. The use of early morning sputum samples (EMS) to diagnose tuberculosis (TB) can result in treatment delay given the need for the patient to return to the clinic with the EMS, increasing the chance of patients ...

    Authors: Michael E. Murphy, Patrick P. J. Phillips, Carl M. Mendel, Emily Bongard, Anna L. C. Bateson, Robert Hunt, Saraswathi Murthy, Kasha P. Singh, Michael Brown, Angela M. Crook, Andrew J. Nunn, Sarah K. Meredith, Marc Lipman, Timothy D. McHugh and Stephen H. Gillespie
    Citation: BMC Medicine 2017 15:192
  34. Given our increasingly diverse societies, there is an urgent need for research into the causes of persistent ethnic disparities in undergraduate clinical performance. It is argued that causes for underperforma...

    Authors: Karen M. Stegers-Jager
    Citation: BMC Medicine 2017 15:190

    The original article was published in BMC Medicine 2017 15:179

  35. Asian medical students and doctors receive lower scores on average than their white counterparts in examinations in the UK and internationally (a phenomenon known as “differential attainment”). This could be d...

    Authors: Peter Yeates, Katherine Woolf, Emyr Benbow, Ben Davies, Mairhead Boohan and Kevin Eva
    Citation: BMC Medicine 2017 15:179

    The Commentary to this article has been published in BMC Medicine 2017 15:190

  36. This study has attempted to assess the effectiveness of quantitative faecal immunochemical tests (FIT) for triage of people presenting with lower abdominal symptoms, where a referral to secondary care for inve...

    Authors: Marie Westwood, Shona Lang, Nigel Armstrong, Sietze van Turenhout, Joaquín Cubiella, Lisa Stirk, Isaac Corro Ramos, Marianne Luyendijk, Remziye Zaim, Jos Kleijnen and Callum G. Fraser
    Citation: BMC Medicine 2017 15:189
  37. Jox and colleagues recently compared and contrasted two leading end-of-life exit options, namely voluntarily stopping eating and drinking (VSED) and medical aid in dying (MAID). The authors argue that policyma...

    Authors: Thaddeus Mason Pope
    Citation: BMC Medicine 2017 15:187

    The original article was published in BMC Medicine 2017 15:186

    The original article was published in BMC Medicine 2017 15:186

  38. Physician-assisted dying has been the subject of extensive discussion and legislative activity both in Europe and North America. In this context, dying by voluntary stopping of eating and drinking (VSED) is of...

    Authors: Ralf J. Jox, Isra Black, Gian Domenico Borasio and Johanna Anneser
    Citation: BMC Medicine 2017 15:186

    The Commentary to this article has been published in BMC Medicine 2017 15:187

  39. Scale-up of malaria interventions over the last decade have yielded a significant reduction in malaria transmission and disease burden in sub-Saharan Africa. We estimated economic gradients in the distribution...

    Authors: Katya Galactionova, Thomas A. Smith, Don de Savigny and Melissa A. Penny
    Citation: BMC Medicine 2017 15:185
  40. One-third of inflammatory bowel disease (IBD) patients show no response to infliximab (IFX) induction therapy, and approximately half of patients responding become unresponsive over time. Thus, identification ...

    Authors: Jacob Tveiten Bjerrum, Casper Steenholdt, Mark Ainsworth, Ole Haagen Nielsen, Michelle AC Reed, Karen Atkins, Ulrich Leonhard Günther, Fuhua Hao and Yulan Wang
    Citation: BMC Medicine 2017 15:184
  41. Expression of group A and the A-like subset of group B Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is associated with severe malaria (SM). The diversity of var sequences combined with the challe...

    Authors: Estela Shabani, Benjamin Hanisch, Robert O. Opoka, Thomas Lavstsen and Chandy C. John
    Citation: BMC Medicine 2017 15:183
  42. Pakistan is one of only three countries where poliovirus circulation remains endemic. For the Pakistan Polio Eradication Program, identifying high risk districts is essential to target interventions and alloca...

    Authors: Laina D. Mercer, Rana M. Safdar, Jamal Ahmed, Abdirahman Mahamud, M. Muzaffar Khan, Sue Gerber, Aiden O’Leary, Mike Ryan, Frank Salet, Steve J. Kroiss, Hil Lyons, Alexander Upfill-Brown and Guillaume Chabot-Couture
    Citation: BMC Medicine 2017 15:180

    The Commentary to this article has been published in BMC Medicine 2017 15:221

  43. The clinical development of a single encounter treatment for uncomplicated malaria has the potential to significantly improve the effectiveness of antimalarials. Exploratory data suggested that the combination...

    Authors: Fiona Macintyre, Yeka Adoke, Alfred B. Tiono, Tran Thanh Duong, Ghyslain Mombo-Ngoma, Marielle Bouyou-Akotet, Halidou Tinto, Quique Bassat, Saadou Issifou, Marc Adamy, Helen Demarest, Stephan Duparc, Didier Leroy, Bart E. Laurijssens, Sophie Biguenet, Afizi Kibuuka…
    Citation: BMC Medicine 2017 15:181