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  1. Because training of the lumbar muscles is a commonly recommended intervention in low back pain (LBP), it is important to clarify whether lumbar muscle atrophy is related to LBP. Fat infiltration seems to be a ...

    Authors: Per Kjaer, Tom Bendix, Joan Solgaard Sorensen, Lars Korsholm and Charlotte Leboeuf-Yde

    Citation: BMC Medicine 2007 5:2

    Content type: Research article

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  2. The increased sympathetic nervous activity in patients with obstructive sleep apnea (OSA) is largely responsible for the high prevalence of arterial hypertension, and it is suggested to adversely affect trigly...

    Authors: Nina K Bartels, Jan Börgel, Stefan Wieczorek, Nikolaus Büchner, Christoph Hanefeld, Daniel Bulut, Andreas Mügge, Lars C Rump, Bernd M Sanner and Jörg T Epplen

    Citation: BMC Medicine 2007 5:1

    Content type: Research article

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  3. Stromal-epithelial interactions are of particular significance in breast tissue as misregulation of these interactions can promote tumorigenesis and invasion. Moreover, collagen-dense breast tissue increases t...

    Authors: Paolo P Provenzano, Kevin W Eliceiri, Jay M Campbell, David R Inman, John G White and Patricia J Keely

    Citation: BMC Medicine 2006 4:38

    Content type: Research article

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  4. Pendred syndrome, an autosomal-recessive disorder characterized by deafness and goiter, is caused by a mutation of SLC26A4, which codes for the anion exchanger pendrin. We investigated the relationship between pe...

    Authors: Sairam V Jabba, Alisha Oelke, Ruchira Singh, Rajanikanth J Maganti, Sherry Fleming, Susan M Wall, Lorraine A Everett, Eric D Green and Philine Wangemann

    Citation: BMC Medicine 2006 4:37

    Content type: Research article

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  5. Neural tube defects (NTDs) are among the most common of all human congenital defects. Over the last two decades, accumulating evidence has made it clear that periconceptional intake of folic acid can significa...

    Authors: James O Ebot Enaw, Huiping Zhu, Wei Yang, Wei Lu, Gary M Shaw, Edward J Lammer and Richard H Finnell

    Citation: BMC Medicine 2006 4:36

    Content type: Research article

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  6. Population impact measures (PIMs) have been developed as tools to help policy-makers with locally relevant decisions over health risks and benefits. This involves estimating and prioritising potential benefits...

    Authors: Richard F Heller, Islay Gemmell, Richard Edwards, Iain Buchan, Shally Awasthi and James A Volmink

    Citation: BMC Medicine 2006 4:35

    Content type: Research article

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  7. A polymorphism in the transcription factor 7-like 2 (TCF7L2) gene has been found to be associated with type 2 diabetes in case-control studies. We aimed to estimate associations of the marker rs7903146 (C/T) poly...

    Authors: David Melzer, Anna Murray, Alison J Hurst, Michael N Weedon, Stefania Bandinelli, Anna Maria Corsi, Luigi Ferrucci, Guiseppe Paolisso, Jack M Guralnik and Timothy M Frayling

    Citation: BMC Medicine 2006 4:34

    Content type: Research article

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  8. Australian epidemiologists have recognised that lay readers have difficulty understanding statistical graphs in reports on population health. This study aimed to provide evidence for graph design improvements ...

    Authors: David J Muscatello, Andrew Searles, Robin Macdonald and Louisa Jorm

    Citation: BMC Medicine 2006 4:33

    Content type: Research article

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  9. The human immunodeficiency virus (HIV) burden among adults in India is estimated officially by direct extrapolation of annual sentinel surveillance data from public-sector antenatal and sexually transmitted in...

    Authors: Lalit Dandona, Vemu Lakshmi, Talasila Sudha, G Anil Kumar and Rakhi Dandona

    Citation: BMC Medicine 2006 4:31

    Content type: Research article

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  10. We hypothesised that subjects at familial high risk of developing schizophrenia would have a reduction over time in grey matter, particularly in the temporal lobes, and that this reduction may predict schizoph...

    Authors: Dominic E Job, Heather C Whalley, Andrew M McIntosh, David GC Owens, Eve C Johnstone and Stephen M Lawrie

    Citation: BMC Medicine 2006 4:29

    Content type: Research article

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  11. Skin toxicity is a common side effect of radiotherapy for solid tumors. Its management can cause treatment gaps and thus can impair cancer treatment. At present, in many countries no standard recommendation fo...

    Authors: Frank Pajonk, Anja Riedisser, Michael Henke, William H McBride and Bernd Fiebich

    Citation: BMC Medicine 2006 4:28

    Content type: Research article

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  12. Accurate reporting of adverse events occurring after vaccination is an important component of determining risk-benefit ratios for vaccinations. Controversy has developed over alleged underreporting of adverse ...

    Authors: Walter R Schumm

    Citation: BMC Medicine 2006 4:27

    Content type: Correspondence

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  13. With an influenza pandemic seemingly imminent, we constructed a model simulating the spread of influenza within the community, in order to test the impact of various interventions.

    Authors: Fabrice Carrat, Julie Luong, Hervé Lao, Anne-Violaine Sallé, Christian Lajaunie and Hans Wackernagel

    Citation: BMC Medicine 2006 4:26

    Content type: Research article

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  14. Many risk factors for fractures have been documented, including low bone-mineral density (BMD) and a history of fractures. However, little is known about the short-term absolute risk (AR) of fractures and the ...

    Authors: Antonia CM van Geel, Piet P Geusens, Ivo F Nagtzaam, Cyril MJR Schreurs, Danny JM van der Voort, Paula ELM Rinkens, Arnold DM Kester and Geert-Jan Dinant

    Citation: BMC Medicine 2006 4:24

    Content type: Research article

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  15. We highlight a chronic inflammatory disease we call 'hyper-IgG4 disease', which has many synonyms depending on the organ involved, the country of origin and the year of the report. It is characterized histolog...

    Authors: Guy H Neild, Manuel Rodriguez-Justo, Catherine Wall and John O Connolly

    Citation: BMC Medicine 2006 4:23

    Content type: Research article

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  16. Israeli citizens have been exposed to intense and ongoing terrorism since September 2000. We previously studied the mental health impact of terrorism on the Israeli population (Bleich et al., 2002), however th...

    Authors: Avi Bleich, Marc Gelkopf, Yuval Melamed and Zahava Solomon

    Citation: BMC Medicine 2006 4:21

    Content type: Research article

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  17. During the past few decades, research has reported gender bias in various areas of clinical and academic medicine. To prevent such bias, a gender perspective in medicine has been requested, but difficulties an...

    Authors: Gunilla Risberg, Katarina Hamberg and Eva E Johansson

    Citation: BMC Medicine 2006 4:20

    Content type: Research article

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  18. The aim of this study was to assess the incidence of sickness absence with psychiatric diagnoses from 1994–2000, and the distribution across gender, age groups, diagnostic groups and regions in a general popul...

    Authors: Gunnel Hensing, Lena Andersson and Sören Brage

    Citation: BMC Medicine 2006 4:19

    Content type: Research article

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  19. No efficacy studies of influenza vaccination given to GPs have yet been published. Therefore, our purpose was to assess the effect of an inactivated influenza vaccine given to GPs on the rate of clinical respi...

    Authors: Michiels Barbara, Philips Hilde, Coenen Samuel, Yane Fernande, Steinhauser Toon, Stuyck Sofie, Denekens Joke and Van Royen Paul

    Citation: BMC Medicine 2006 4:17

    Content type: Research article

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  20. Postmenopausal hormone-replacement therapy (HRT) increases breast-cancer risk. The influence of HRT on the biology of the primary tumor, however, is not well understood.

    Authors: Per Hall, Alexander Ploner, Judith Bjöhle, Fei Huang, Chin-Yo Lin, Edison T Liu, Lance D Miller, Hans Nordgren, Yudi Pawitan, Peter Shaw, Lambert Skoog, Johanna Smeds, Sara Wedrén, John Öhd and Jonas Bergh

    Citation: BMC Medicine 2006 4:16

    Content type: Research article

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  21. While delirium is common among older adults in acute care hospitals, its prevalence in other settings has been less well studied. We examined delirium prevalence and outcomes in a large cohort of older Canadia...

    Authors: Melissa K Andrew, Susan H Freter and Kenneth Rockwood

    Citation: BMC Medicine 2006 4:15

    Content type: Research article

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  22. The aim of the current study was to assess the antidepressant efficacy and safety of Hypericum perforatum (St. John's wort) extract WS® 5570 at doses of 600 mg/day in a single dose and 1200 mg/day in two doses.

    Authors: Siegfried Kasper, Ion-George Anghelescu, Armin Szegedi, Angelika Dienel and Meinhard Kieser

    Citation: BMC Medicine 2006 4:14

    Content type: Research article

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  23. BioMed Central (BMC) requires authors to suggest four reviewers when making a submission. Editors searching for reviewers use these suggestions as a source. The review process of the medical journals in the BMC ...

    Authors: Elizabeth Wager, Emma C Parkin and Pritpal S Tamber

    Citation: BMC Medicine 2006 4:13

    Content type: Research article

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  24. The beneficial effect of aspirin after coronary surgery is established; however, a recent study reported the inability of low doses (100 mg) to inhibit postoperative platelet function. We conducted a double-bl...

    Authors: Eric Lim, Jacqueline Cornelissen, Tom Routledge, Ayyaz Ali, Stephen Kirtland, Linda Sharples, Kate Sheridan, Sarah Bellm, Helen Munday and Stephen Large

    Citation: BMC Medicine 2006 4:12

    Content type: Research article

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  25. Procedural pain relief is sub-optimal in infants, especially small and vulnerable ones. Tetracaine gel 4% (Ametop®, Smith-Nephew) provides pain relief in children and larger infants, but its efficacy in smaller i...

    Authors: Brigitte Lemyre, Rebecca Sherlock, Debora Hogan, Isabelle Gaboury, Colline Blanchard and David Moher

    Citation: BMC Medicine 2006 4:11

    Content type: Research article

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  26. Chronic fatigue syndrome, also known as ME (CFS/ME), is a condition characterised primarily by severe, disabling fatigue, of unknown origin, which has a poor prognosis and serious personal and economic consequ...

    Authors: AJ Wearden, L Riste, C Dowrick, C Chew-Graham, RP Bentall, RK Morriss, S Peters, G Dunn, G Richardson, K Lovell and P Powell

    Citation: BMC Medicine 2006 4:9

    Content type: Study protocol

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  27. Japanese encephalitis (JE) is presumed to be endemic throughout Asia, yet only a few cases have been reported in tropical Asian countries such as Indonesia, Malaysia and the Philippines. To estimate the true d...

    Authors: Komang Kari, Wei Liu, Kompiang Gautama, Mammen P Mammen Jr, John D Clemens, Ananda Nisalak, Ketut Subrata, Hyei Kyung Kim and Zhi-Yi Xu

    Citation: BMC Medicine 2006 4:8

    Content type: Research article

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  28. A recent estimate by the World Health Organization (WHO) suggests that 161 million persons worldwide have visual impairment, including 37 million blind (best-corrected visual acuity less than 3/60 in the bette...

    Authors: Lalit Dandona and Rakhi Dandona

    Citation: BMC Medicine 2006 4:6

    Content type: Research article

    Published on:

  29. Differences in HLA allele frequencies between the diseased and healthy populations may signify efficient immune responses, a notion that has been successfully tested for infectious diseases or for association ...

    Authors: Joachim Fensterle, Uwe Trefzer, Thomas Berger, Mads Hald Andersen, Selma Ugurel and Jürgen C Becker

    Citation: BMC Medicine 2006 4:5

    Content type: Research article

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  30. Alternating ibuprofen and acetaminophen for the treatment of febrile children is a prevalent practice among physicians and parents, despite the lack of evidence on effectiveness or safety. This randomized, dou...

    Authors: Mona M Nabulsi, Hala Tamim, Ziyad Mahfoud, Mohammad Itani, Ramzi Sabra, Fadi Chamseddine and Mohammad Mikati

    Citation: BMC Medicine 2006 4:4

    Content type: Research article

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  31. As part of the NHS plan it was suggested that all patients receive copies of letters sent to their General Practitioner following outpatient consultations. The former Secretary of State for Health extended thi...

    Authors: Nicola J Roberts and Martyn R Partridge

    Citation: BMC Medicine 2006 4:2

    Content type: Research article

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  32. The presence of the apolipoprotein E (APOE) ε4 allele is a major risk factor for the development of Alzheimer's disease (AD), and has been associated with metabolic brain changes several years before the onset...

    Authors: Mehul A Trivedi, Taylor W Schmitz, Michele L Ries, Britta M Torgerson, Mark A Sager, Bruce P Hermann, Sanjay Asthana and Sterling C Johnson

    Citation: BMC Medicine 2006 4:1

    Content type: Research article

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  33. Stopping antipsychotic treatment can interrupt improvement and exacerbate the illness. The reasons for discontinuing treatment during controlled clinical trials were analyzed to explore this phenomenon.

    Authors: Hong Liu-Seifert, David H Adams and Bruce J Kinon

    Citation: BMC Medicine 2005 3:21

    Content type: Research article

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  34. Cyclic Vomiting Syndrome (CVS) is a disorder characterized by recurrent, stereotypic episodes of incapacitating nausea, vomiting and other symptoms, separated by intervals of comparative wellness. This report ...

    Authors: David R Fleisher, Blake Gornowicz, Kathleen Adams, Richard Burch and Edward J Feldman

    Citation: BMC Medicine 2005 3:20

    Content type: Research article

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  35. The lack of standardized criteria for defining chronic fatigue syndrome (CFS) has constrained research. The objective of this study was to apply the 1994 CFS criteria by standardized reproducible criteria.

    Authors: William C Reeves, Dieter Wagner, Rosane Nisenbaum, James F Jones, Brian Gurbaxani, Laura Solomon, Dimitris A Papanicolaou, Elizabeth R Unger, Suzanne D Vernon and Christine Heim

    Citation: BMC Medicine 2005 3:19

    Content type: Research article

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  36. Miscarriage and induced abortion are life events that can potentially cause mental distress. The objective of this study was to determine whether there are differences in the patterns of normalization of menta...

    Authors: Anne Nordal Broen, Torbjørn Moum, Anne Sejersted Bødtker and Øivind Ekeberg

    Citation: BMC Medicine 2005 3:18

    Content type: Research article

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  37. Recent data indicate that chronic use of coxibs leads to an increased occurrence of thrombotic cardiovascular events. This raises the question as to whether traditional non-steroidal anti-inflammatory drugs (t...

    Authors: Luis A García Rodríguez and Antonio González-Pérez

    Citation: BMC Medicine 2005 3:17

    Content type: Research article

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  38. Self-prescribing among doctors is common, but no longitudinal studies have documented this issue. We studied the self-prescribing behaviour among young Norwegian physicians and the predictors of self-prescribing.

    Authors: Erlend Hem, Guro Stokke, Reidar Tyssen, Nina T Grønvold, Per Vaglum and Øivind Ekeberg

    Citation: BMC Medicine 2005 3:16

    Content type: Research article

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  39. Chlorpromazine (CPZ) remains one of the most common drugs used for people with schizophrenia worldwide, and a benchmark against which other treatments can be evaluated. Quantitative reviews are rare; this one ...

    Authors: Clive Elliott Adams, John Rathbone, Ben Thornley, Mike Clarke, Jo Borrill, Kristian Wahlbeck and A George Awad

    Citation: BMC Medicine 2005 3:15

    Content type: Research article

    Published on:

Announcement: COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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