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  1. Sepsis is the clinical syndrome derived from the host response to an infection and severe sepsis is the leading cause of death in critically ill patients. Several biomarkers have been tested for use in diagnos...

    Authors: Katia Donadello, Sabino Scolletta, Cecilia Covajes and Jean-Louis Vincent
    Citation: BMC Medicine 2012 10:2
  2. The Alvarado score can be used to stratify patients with symptoms of suspected appendicitis; the validity of the score in certain patient groups and at different cut points is still unclear. The aim of this st...

    Authors: Robert Ohle, Fran O'Reilly, Kirsty K O'Brien, Tom Fahey and Borislav D Dimitrov
    Citation: BMC Medicine 2011 9:139
  3. Mental disorders are associated with a considerable burden of disease as well as being risk factors for other health outcomes. The new Global Burden of Disease (GBD) Study will make estimates for both the disa...

    Authors: Amanda J Baxter, Fiona J Charlson, Adele J Somerville and Harvey A Whiteford
    Citation: BMC Medicine 2011 9:134
  4. About half of Americans 50 to 75 years old do not follow recommended colorectal cancer (CRC) screening guidelines, leaving 40 million individuals unscreened. A simple blood test would increase screening compli...

    Authors: Jorja D Warren, Wei Xiong, Ashley M Bunker, Cecily P Vaughn, Larissa V Furtado, William L Roberts, John C Fang, Wade S Samowitz and Karen A Heichman
    Citation: BMC Medicine 2011 9:133
  5. The validation of biomarkers has become a key goal of translational biomedical research. The purpose of this article is to discuss the role of biomarkers in the management of acute lung injury (ALI) and relate...

    Authors: Alastair G Proudfoot, Matthew Hind and Mark JD Griffiths
    Citation: BMC Medicine 2011 9:132
  6. Kawasaki disease is an acute vasculitis of infants and young children that is recognized through a constellation of clinical signs that can mimic other benign conditions of childhood. The etiology remains unkn...

    Authors: Xuefeng B Ling, Kenneth Lau, John T Kanegaye, Zheng Pan, Sihua Peng, Jun Ji, Gigi Liu, Yuichiro Sato, Tom TS Yu, John C Whitin, James Schilling, Jane C Burns and Harvey J Cohen
    Citation: BMC Medicine 2011 9:130
  7. Currently available pharmacological and non-pharmacological treatments have shown only modest effects in slowing the progression of dementia. Our objective was to assess the impact of a long-term non-pharmacol...

    Authors: Elmar Graessel, Renate Stemmer, Birgit Eichenseer, Sabine Pickel, Carolin Donath, Johannes Kornhuber and Katharina Luttenberger
    Citation: BMC Medicine 2011 9:129
  8. Effective strategies for the primary prevention of low back pain (LBP) remain elusive with few large-scale clinical trials investigating exercise and education approaches. The purpose of this trial was to dete...

    Authors: Steven Z George, John D Childs, Deydre S Teyhen, Samuel S Wu, Alison C Wright, Jessica L Dugan and Michael E Robinson
    Citation: BMC Medicine 2011 9:128
  9. Endothelial dysfunction has been proposed as the underlying cause of diabetic angiopathy that eventually leads to cardiovascular disease, the major cause of death in diabetes. We recently demonstrated the amel...

    Authors: Sakineh Shab-Bidar, Tirang R Neyestani, Abolghassem Djazayery, Mohammad-Reza Eshraghian, Anahita Houshiarrad, A'azam Gharavi, Ali Kalayi, Nastaran Shariatzadeh, Malihe Zahedirad, Niloufar Khalaji and Homa Haidari
    Citation: BMC Medicine 2011 9:125
  10. The major metabolic complications of obesity and type 2 diabetes may be prevented and managed with dietary modification. The use of sweeteners that provide little or no calories may help to achieve this object...

    Authors: Natasha Wiebe, Raj Padwal, Catherine Field, Seth Marks, Rene Jacobs and Marcello Tonelli
    Citation: BMC Medicine 2011 9:123
  11. In England, trauma is the leading cause of death across all age groups, with over 16,000 deaths per year. Major trauma implies the presence of multiple, serious injuries that could result in death or serious d...

    Authors: Nikolaos K Kanakaris and Peter V Giannoudis
    Citation: BMC Medicine 2011 9:121
  12. Type 1 diabetes is one of the most common endocrine problems in childhood and adolescence, and remains a serious chronic disorder with increased morbidity and mortality, and reduced quality of life. Technologi...

    Authors: Daniela Elleri, David B Dunger and Roman Hovorka
    Citation: BMC Medicine 2011 9:120
  13. Cocaine is a stimulant that leads to the rapid accumulation of catecholamines and serotonin in the brain due to prevention of their re-uptake into the neuron that released the neurotransmitter. Cocaine depende...

    Authors: Daryl Shorter and Thomas R Kosten
    Citation: BMC Medicine 2011 9:119
  14. Health care disparity is a public health challenge. We compared the prevalence of diabetes, quality of care and outcomes between mental health clients (MHCs) and non-MHCs.

    Authors: Qun Mai, C D'Arcy J Holman, Frank M Sanfilippo, Jonathan D Emery and David B Preen
    Citation: BMC Medicine 2011 9:118
  15. Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR), is the most commonly applied broad-spectrum herbicide in the world. Unintentional overspray of ATR poses an immune function health hazard...

    Authors: Xiaofeng Zhang, Mingqiu Wang, Shuying Gao, Rui Ren, Jing Zheng and Yang Zhang
    Citation: BMC Medicine 2011 9:117
  16. Migraine is a highly prevalent neurological disorder imparting a major burden on health care around the world. The primary pathology may be a state of hyperresponsiveness of the nervous system, but the molecul...

    Authors: Greg A Weir and M Zameel Cader
    Citation: BMC Medicine 2011 9:116
  17. Major depression, although frequent in primary care, is commonly hidden behind multiple physical complaints that are often the first and only reason for patient consultation. Major depression can be screened b...

    Authors: Patrick Lombardo, Paul Vaucher, Nader Haftgoli, Bernard Burnand, Bernard Favrat, François Verdon, Thomas Bischoff and Lilli Herzig
    Citation: BMC Medicine 2011 9:114
  18. Metal-on-metal hybrid hip resurfacing arthroplasty (with a cementless acetabular component and a cemented femoral component) is offered as an alternative to traditional total hip arthroplasty for the young and...

    Authors: Andrea Hinsch, Eik Vettorazzi, Michael M Morlock, Wolfgang Rüther, Michael Amling and Jozef Zustin
    Citation: BMC Medicine 2011 9:113
  19. Friedreich's ataxia, the most frequent progressive autosomal recessive disorder involving the central and peripheral nervous systems, is mostly associated with unstable expansion of GAA trinucleotide repeats i...

    Authors: Aurélien Bayot, Renata Santos, Jean-Michel Camadro and Pierre Rustin
    Citation: BMC Medicine 2011 9:112
  20. China has experienced an increasing epidemic of sexually transmitted infections (STIs), including HIV. High risk groups likely to be infected include female sex workers (FSWs) and their clients, men who have s...

    Authors: Xiang-Sheng Chen, Rosanna W Peeling, Yue-Ping Yin and David C Mabey
    Citation: BMC Medicine 2011 9:111
  21. Low levels of physical activity may increase the risk of developing metabolic syndrome, a cluster of metabolic factors that are associated with the risk of premature death. It has been suggested that physical ...

    Authors: Dorthe Stensvold, Javaid Nauman, Tom IL Nilsen, Ulrik Wisløff, Stig A Slørdahl and Lars Vatten
    Citation: BMC Medicine 2011 9:109
  22. Low back pain is a common and costly condition and for most people is likely to be a recurrent problem throughout their lifetime. The management of patients with low back pain has been positively influenced by...

    Authors: Nadine E Foster
    Citation: BMC Medicine 2011 9:108
  23. Increases in human telomerase reverse transcriptase (TERT) expression and telomerase activity are frequently seen in nasopharyngeal carcinoma (NPC). Recently, a variable tandem-repeats polymorphism, MNS16A, lo...

    Authors: Yang Zhang, Hongxing Zhang, Yun Zhai, Zhifu Wang, Fuchao Ma, Hongxue Wang, Peiyao Li, Ying Zhang, Lixia Yu, Ying Cui, Fuchu He and Gangqiao Zhou
    Citation: BMC Medicine 2011 9:106
  24. Indigenous women in Australia have a disproportionate burden of cervical cancer despite a national cervical screening program. Prior to introduction of a national human papilloma virus (HPV) vaccination progra...

    Authors: Suzanne M Garland, Julia ML Brotherton, John R Condon, Peter B McIntyre, Matthew P Stevens, David W Smith and Sepehr N Tabrizi
    Citation: BMC Medicine 2011 9:104
  25. The World Health Organisation estimates that by 2030 there will be approximately 350 million people with type 2 diabetes. Associated with renal complications, heart disease, stroke and peripheral vascular dise...

    Authors: Gary S Collins, Susan Mallett, Omar Omar and Ly-Mee Yu
    Citation: BMC Medicine 2011 9:103
  26. Many patients with asthma have poorly controlled symptoms, and particularly for those with severe disease, there is a clear need for improved treatments. Two recent therapies licensed for use in asthma are oma...

    Authors: Neil C Thomson, Rekha Chaudhuri and Mark Spears
    Citation: BMC Medicine 2011 9:102
  27. Sir William Osler suggested in 1899 that avocations (leisure activities) in doctors are related to an increased sense of vocation (professional engagement) and a decreased level of burnout. This study evaluate...

    Authors: I C McManus, Hallgeir Jonvik, Peter Richards and Elisabeth Paice
    Citation: BMC Medicine 2011 9:100
  28. Although imatinib is firmly established as an effective therapy for newly diagnosed patients with chronic myeloid leukemia (CML), the field continues to advance on several fronts. In this minireview we cover r...

    Authors: Anna M Eiring, Jamshid S Khorashad, Kimberly Morley and Michael W Deininger
    Citation: BMC Medicine 2011 9:99
  29. The molecular mechanisms of aging are the subject of much research and have facilitated potential interventions to delay aging and aging-related degenerative diseases in humans. The aging process is frequently...

    Authors: Yuanyuan Li, Michael Daniel and Trygve O Tollefsbol
    Citation: BMC Medicine 2011 9:98
  30. Smokers have been shown to have lower mortality after acute coronary syndrome than non-smokers. This has been attributed to the younger age, lower co-morbidity, more aggressive treatment and lower risk profile...

    Authors: Erlend Aune, Jo Røislien, Mariann Mathisen, Dag S Thelle and Jan Erik Otterstad
    Citation: BMC Medicine 2011 9:97
  31. The postdischarge period is a vulnerable time for patients, with high rates of adverse events that may cause unnecessary readmissions, especially in the elderly. Because postdischarge care continuity is often ...

    Authors: Chin-Chung Shu, Nin-Chieh Hsu, Yu-Feng Lin, Jann-Yuan Wang, Jou-Wei Lin and Wen-Je Ko
    Citation: BMC Medicine 2011 9:96
  32. Herbal products obtained over the counter are commonly used in Europe, North America and Australia. Although there is concern about a lack of information provided to consumers to allow the safe use of these pr...

    Authors: David K Raynor, Rebecca Dickinson, Peter Knapp, Andrew F Long and Donald J Nicolson
    Citation: BMC Medicine 2011 9:94
  33. In many developing countries, the majority of births are attended by traditional birth attendants, who lack formal training in neonatal resuscitation and other essential care required by the newly born infant....

    Authors: Richard Matendo, Cyril Engmann, John Ditekemena, Justin Gado, Antoinette Tshefu, Rinko Kinoshita, Elizabeth M McClure, Janet Moore, Dennis Wallace, Waldemar A Carlo, Linda L Wright and Carl Bose
    Citation: BMC Medicine 2011 9:93
  34. Current evidence indicates that probiotic supplementation significantly reduces all-cause mortality and definite necrotising enterocolitis without significant adverse effects in preterm neonates. As the debate...

    Authors: Girish C Deshpande, Shripada C Rao, Anthony D Keil and Sanjay K Patole
    Citation: BMC Medicine 2011 9:92