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  1. The presence of metastatic disease in cervical lymph nodes of head and neck squamous cell carcinoma (HNSCC) patients is a very important determinant in therapy choice and prognosis, with great impact in overal...

    Authors: Ana Carolina de Carvalho, Cristovam Scapulatempo-Neto, Danielle Calheiros Campelo Maia, Adriane Feijó Evangelista, Mariana Andozia Morini, André Lopes Carvalho and André Luiz Vettore
    Citation: BMC Medicine 2015 13:108

    The Erratum to this article has been published in BMC Medicine 2015 13:155

  2. Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for ca...

    Authors: Dora Romaguera, Heather Ward, Petra A Wark, Anne-Claire Vergnaud, Petra H Peeters, Carla H van Gils, Pietro Ferrari, Veronika Fedirko, Mazda Jenab, Marie-Christine Boutron-Ruault, Laure Dossus, Laureen Dartois, Camilla Plambeck Hansen, Christina Catherine Dahm, Genevieve Buckland, María José Sánchez…
    Citation: BMC Medicine 2015 13:107
  3. Medical apps are widely available, increasingly used by patients and clinicians, and are being actively promoted for use in routine care. However, there is little systematic evidence exploring possible risks a...

    Authors: Kit Huckvale, Samanta Adomaviciute, José Tomás Prieto, Melvin Khee-Shing Leow and Josip Car
    Citation: BMC Medicine 2015 13:106
  4. Coagulation and innate immunity have been linked together for at least 450 million years of evolution. Sepsis, one of the world’s leading causes of death, is probably the condition in which this evolutionary l...

    Authors: Maiara Marx Luz Fiusa, Marco Antonio Carvalho-Filho, Joyce M Annichino-Bizzacchi and Erich V De Paula
    Citation: BMC Medicine 2015 13:105
  5. Urinary tract infections (UTIs) are common drivers of antibiotic use. The minimal effective duration of antibiotic therapy for UTIs is unknown, but any reduction is important to diminish selection pressure for...

    Authors: Daniel Drozdov, Stefanie Schwarz, Alexander Kutz, Eva Grolimund, Anna Christina Rast, Deborah Steiner, Katharina Regez, Ursula Schild, Merih Guglielmetti, Antoinette Conca, Barbara Reutlinger, Cornelia Ottiger, Florian Buchkremer, Sebastian Haubitz, Claudine Blum, Andreas Huber…
    Citation: BMC Medicine 2015 13:104
  6. In December 2013, an outbreak of Chikungunya virus (CHIKV) caused by the Asian genotype was notified in the Caribbean. The outbreak has since spread to 38 regions in the Americas. By September 2014, the first ...

    Authors: Marcio Roberto Teixeira Nunes, Nuno Rodrigues Faria, Janaina Mota de Vasconcelos, Nick Golding, Moritz UG Kraemer, Layanna Freitas de Oliveira, Raimunda do Socorro da Silva Azevedo, Daisy Elaine Andrade da Silva, Eliana Vieira Pinto da Silva, Sandro Patroca da Silva, Valéria Lima Carvalho, Giovanini Evelim Coelho, Ana Cecília Ribeiro Cruz, Sueli Guerreiro Rodrigues, Joao Lídio da Silva Gonçalves Vianez Jr, Bruno Tardelli Diniz Nunes…
    Citation: BMC Medicine 2015 13:102
  7. Dengue has been a notifiable disease in China since 1 September 1989. Cases have been reported each year during the past 25 years of dramatic socio-economic changes in China, and reached a historical high in 2...

    Authors: Shengjie Lai, Zhuojie Huang, Hang Zhou, Katherine L Anders, T Alex Perkins, Wenwu Yin, Yu Li, Di Mu, Qiulan Chen, Zike Zhang, Yanzi Qiu, Liping Wang, Honglong Zhang, Linjia Zeng, Xiang Ren, Mengjie Geng…
    Citation: BMC Medicine 2015 13:100
  8. The number of reports in the literature on dengue outbreaks in various parts of south China is increasing. This trend is likely contributed to by multiple factors, chief among which is the increase in trade an...

    Authors: Eng Eong Ooi
    Citation: BMC Medicine 2015 13:99
  9. Sepsis is associated with significant morbidity and mortality if not promptly recognized and treated. Since the development of early goal-directed therapy, mortality rates have decreased, but sepsis remains a ...

    Authors: Donald M Yealy, David T Huang, Anthony Delaney, Marian Knight, Adrienne G Randolph, Ron Daniels and Tim Nutbeam
    Citation: BMC Medicine 2015 13:98
  10. Thrombocytopenia is a common finding in adults with severe falciparum malaria, but its clinical and prognostic utility is incompletely defined.

    Authors: Josh Hanson, Nguyen Hoan Phu, Mahtab Uddin Hasan, Prakaykaew Charunwatthana, Katherine Plewes, Richard J Maude, Panote Prapansilp, Hugh WF Kingston, Saroj K Mishra, Sanjib Mohanty, Ric N Price, M Abul Faiz, Arjen M Dondorp, Nicholas J White, Tran Tinh Hien and Nicholas PJ Day
    Citation: BMC Medicine 2015 13:97
  11. Ebola is one of the most virulent human viral diseases, with a case fatality ratio between 25% to 90%. The 2014 West African outbreaks are the largest and worst in history. There is no specific treatment or ef...

    Authors: Folashade B Agusto, Miranda I Teboh-Ewungkem and Abba B Gumel
    Citation: BMC Medicine 2015 13:96
  12. In animal models, lack of thyroid hormone is associated with cone photoreceptor preservation, while administration of high doses of active thyroid hormone leads to deterioration. The association between thyroi...

    Authors: Layal Chaker, Gabriëlle HS Buitendijk, Abbas Dehghan, Marco Medici, Albert Hofman, Johannes R Vingerling, Oscar H Franco, Caroline CW Klaver and Robin P Peeters
    Citation: BMC Medicine 2015 13:94
  13. Ready-to-use therapeutic foods (RUTF) are lipid-based pastes widely used in the treatment of acute malnutrition. Current specifications for RUTF permit a high n-6 polyunsaturated fatty acid (PUFA) content and ...

    Authors: Kelsey DJ Jones, Rehema Ali, Maureen A Khasira, Dennis Odera, Annette L West, Grielof Koster, Peter Akomo, Alison WA Talbert, Victoria M Goss, Moses Ngari, Johnstone Thitiri, Said Ndoro, Miguel A Garcia Knight, Kenneth Omollo, Anne Ndungu, Musa M Mulongo…
    Citation: BMC Medicine 2015 13:93
  14. We sought to define quality in telehealth and telecare with the aim of improving the proportion of patients who receive appropriate, acceptable and workable technologies and services to support them living wit...

    Authors: Trisha Greenhalgh, Rob Procter, Joe Wherton, Paul Sugarhood, Sue Hinder and Mark Rouncefield
    Citation: BMC Medicine 2015 13:91
  15. Complex wounds present a substantial economic burden on healthcare systems, costing billions of dollars annually in North America alone. The prevalence of complex wounds is a significant patient and societal h...

    Authors: Andrea C Tricco, Elise Cogo, Wanrudee Isaranuwatchai, Paul A Khan, Geetha Sanmugalingham, Jesmin Antony, Jeffrey S Hoch and Sharon E Straus
    Citation: BMC Medicine 2015 13:90
  16. Numerous, often multi-faceted regimens are available for treating complex wounds, yet the evidence of these interventions is recondite across the literature. We aimed to identify effective interventions to tre...

    Authors: Andrea C Tricco, Jesmin Antony, Afshin Vafaei, Paul A Khan, Alana Harrington, Elise Cogo, Charlotte Wilson, Laure Perrier, Wing Hui and Sharon E Straus
    Citation: BMC Medicine 2015 13:89
  17. In the last 20 years, China ramped up a DOTS (directly observed treatment, short-course)-based tuberculosis (TB) control program with 80% population coverage, achieving the 2015 Millennium Development Goal of ...

    Authors: Grace H Huynh, Daniel J Klein, Daniel P Chin, Bradley G Wagner, Philip A Eckhoff, Renzhong Liu and Lixia Wang
    Citation: BMC Medicine 2015 13:88
  18. Alopecia areata (AA) is one of the most common autoimmune diseases and targets the hair follicles, with high impact on the quality of life and self-esteem of patients due to hair loss. Clinical management and ...

    Authors: Yanjia Li, Baoyong Yan, Hepeng Wang, Heng Li, Quanhai Li, Dong Zhao, Yana Chen, Ye Zhang, Wenxia Li, Jun Zhang, Shanfeng Wang, Jie Shen, Yunxiang Li, Edward Guindi and Yong Zhao
    Citation: BMC Medicine 2015 13:87
  19. Obesity is strongly associated with major depressive disorder (MDD) and various other diseases. Genome-wide association studies have identified multiple risk loci robustly associated with body mass index (BMI)...

    Authors: Chi-Fa Hung, Gerome Breen, Darina Czamara, Tanguy Corre, Christiane Wolf, Stefan Kloiber, Sven Bergmann, Nick Craddock, Michael Gill, Florian Holsboer, Lisa Jones, Ian Jones, Ania Korszun, Zoltan Kutalik, Susanne Lucae, Wolfgang Maier…
    Citation: BMC Medicine 2015 13:86
  20. This is an Erratum to BMC Medicine 2015, 13:59, highlighting previously undeclared competing interests and including more information in the acknowledgements section.

    Authors: Tao Huang, Min Xu, Albert Lee, Susan Cho and Lu Qi
    Citation: BMC Medicine 2015 13:85

    The original article was published in BMC Medicine 2015 13:59

  21. Relapse is high in lifestyle obesity interventions involving behavior and weight change. Identifying mediators of successful outcomes in these interventions is critical to improve effectiveness and to guide ap...

    Authors: Pedro J Teixeira, Eliana V Carraça, Marta M Marques, Harry Rutter, Jean-Michel Oppert, Ilse De Bourdeaudhuij, Jeroen Lakerveld and Johannes Brug
    Citation: BMC Medicine 2015 13:84
  22. Previous studies have shown the prognostic value of stimulation elicited blood-oxygen-level-dependent (BOLD) signal in traumatic patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS). However...

    Authors: Fuyan Wang, Haibo Di, Xiaohua Hu, Shan Jing, Aurore Thibaut, Carol Di Perri, Wangshan Huang, Yunzhi Nie, Caroline Schnakers and Steven Laureys
    Citation: BMC Medicine 2015 13:83
  23. As the number of systematic reviews is growing rapidly, we systematically investigate whether meta-analyses published in leading medical journals present an outline of available evidence by referring to previo...

    Authors: Bartosz Helfer, Aaron Prosser, Myrto T Samara, John R Geddes, Andrea Cipriani, John M Davis, Dimitris Mavridis, Georgia Salanti and Stefan Leucht
    Citation: BMC Medicine 2015 13:82
  24. The Hygiene Hypothesis (HH) attributes the dramatic increase in autoimmune and allergic diseases observed in recent decades in Western countries to the reduced exposure to diverse immunoregulatory infectious a...

    Authors: Mathilde Versini, Pierre-Yves Jeandel, Tomer Bashi, Giorgia Bizzaro, Miri Blank and Yehuda Shoenfeld
    Citation: BMC Medicine 2015 13:81
  25. There is a large treatment gap for mental health care in low- and middle-income countries (LMICs), with the majority of people with mental, neurological, and substance use (MNS) disorders receiving no or inade...

    Authors: Maya Semrau, Sara Evans-Lacko, Atalay Alem, Jose Luis Ayuso-Mateos, Dan Chisholm, Oye Gureje, Charlotte Hanlon, Mark Jordans, Fred Kigozi, Heidi Lempp, Crick Lund, Inge Petersen, Rahul Shidhaye and Graham Thornicroft
    Citation: BMC Medicine 2015 13:79
  26. Treatment for hypertension with antihypertensive medication has been shown to reduce stroke, cardiovascular events, and mortality in older adults, but there is concern that such treatment may not be appropriat...

    Authors: Jane Warwick, Emanuela Falaschetti, Kenneth Rockwood, Arnold Mitnitski, Lutgarde Thijs, Nigel Beckett, Christopher Bulpitt and Ruth Peters
    Citation: BMC Medicine 2015 13:78
  27. The identification of molecular markers with prognostic value in colorectal cancer is a challenging task that is needed to define therapeutic guidelines. Clinical factors are insufficient to identify those pat...

    Authors: Victor Moreno and Rebeca Sanz-Pamplona
    Citation: BMC Medicine 2015 13:76
  28. Studies of colorectal cancer (CRC) have shown that hundreds to thousands of genes are differentially expressed in tumors when compared to normal tissue samples. In this study, we evaluate how genes that are di...

    Authors: Martha L Slattery, Jennifer S Herrick, Lila E Mullany, Jason Gertz and Roger K Wolff
    Citation: BMC Medicine 2015 13:75
  29. The escalating use of prescribed drugs has increasingly raised concerns about polypharmacy. This study aims to examine changes in rates of polypharmacy and potentially serious drug-drug interactions in a stabl...

    Authors: Bruce Guthrie, Boikanyo Makubate, Virginia Hernandez-Santiago and Tobias Dreischulte
    Citation: BMC Medicine 2015 13:74
  30. The Surviving Sepsis Campaign guidelines have proposed early goal-directed therapy (EGDT) as a key strategy to decrease mortality among patients with severe sepsis or septic shock. However, its effectiveness i...

    Authors: Ling Zhang, Guijun Zhu, Li Han and Ping Fu
    Citation: BMC Medicine 2015 13:71
  31. Low haemoglobin concentrations may be predictive of incident tuberculosis (TB) and death in HIV-infected patients receiving antiretroviral therapy (ART), but data are limited and inconsistent. We examined thes...

    Authors: Andrew D Kerkhoff, Robin Wood, Frank G Cobelens, Ankur Gupta-Wright, Linda-Gail Bekker and Stephen D Lawn
    Citation: BMC Medicine 2015 13:70
  32. Achieving universal health coverage and reducing health inequalities are primary goals for an increasing number of health systems worldwide. Timely and accurate measurements of levels and trends in key health ...

    Authors: Katherine Ellicott Colson, Laura Dwyer-Lindgren, Tom Achoki, Nancy Fullman, Matthew Schneider, Peter Mulenga, Peter Hangoma, Marie Ng, Felix Masiye and Emmanuela Gakidou
    Citation: BMC Medicine 2015 13:69
  33. The 2012 World Health Assembly set a target for Member States to reduce premature non-communicable disease (NCD) mortality by 25% over the period 2010 to 2025. This reflected concerns about increasing NCD mort...

    Authors: Ailiana Santosa, Joacim Rocklöv, Ulf Högberg and Peter Byass
    Citation: BMC Medicine 2015 13:65
  34. Alzheimer’s disease (AD) is the foremost cause of dementia worldwide. Clinically, AD manifests as progressive memory impairment followed by a gradual decline in other cognitive abilities leading to complete fu...

    Authors: Michael S Rafii and Paul S Aisen
    Citation: BMC Medicine 2015 13:62