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  1. Intakes of whole grains and cereal fiber have been inversely associated with the risk of chronic diseases; however, their relation with total and disease-specific mortality remain unclear. We aimed to prospect...

    Authors: Tao Huang, Min Xu, Albert Lee, Susan Cho and Lu Qi
    Citation: BMC Medicine 2015 13:59

    The Erratum to this article has been published in BMC Medicine 2015 13:85

  2. Interest in mobile apps that support long-term conditions such as asthma is matched by recognition of the importance of the quality and safety of apps intended for patient use. We assessed how changes over a 2...

    Authors: Kit Huckvale, Cecily Morrison, Jing Ouyang, Aseem Ghaghda and Josip Car
    Citation: BMC Medicine 2015 13:58
  3. The benign character formerly attributed to Plasmodium vivax infection has been dismantled by the increasing number of reports of severe disease associated with infection with this parasite, prompting the need fo...

    Authors: André M Siqueira, Marcus VG Lacerda, Belisa M L Magalhães, Maria PG Mourão, Gisely C Melo, Márcia AA Alexandre, Maria GC Alecrim, Dhanpat Kochar, Sanjay Kochar, Abhishek Kochar, Kailash Nayak, Hernando del Portillo, Caterina Guinovart, Pedro Alonso and Quique Bassat
    Citation: BMC Medicine 2015 13:57
  4. There are several guidelines addressing the issues around the use of NSAIDs. However, none has specifically addressed the upper versus lower gastrointestinal (GI) risk of COX-2 selective and non-selective comp...

    Authors: Carmelo Scarpignato, Angel Lanas, Corrado Blandizzi, Willem F Lems, Matthias Hermann and Richard H Hunt
    Citation: BMC Medicine 2015 13:55
  5. Patients with diabetes are at increased risk of severe influenza disease; influenza vaccination for these patients is therefore recommended by the World Health Organization and several National Immunization Te...

    Authors: Cornelius Remschmidt, Ole Wichmann and Thomas Harder
    Citation: BMC Medicine 2015 13:53
  6. Awareness represents a major modulator for the uptake of preventive measures and healthy life-style choices. Women underestimate the role of cardiovascular diseases as causes of mortality, yet little informati...

    Authors: Sabine Oertelt-Prigione, Ute Seeland, Friederike Kendel, Mirjam Rücke, Agnes Flöel, Wolfgang Gaissmaier, Christine Heim, Renate Schnabel, Verena Stangl and Vera Regitz-Zagrosek
    Citation: BMC Medicine 2015 13:52
  7. Cognitive impairment is common in patients with cerebral small vessel disease, but is not well detected using common cognitive screening tests which have been primarily devised for cortical dementias. We devel...

    Authors: Rebecca L Brookes, Matthew J Hollocks, Usman Khan, Robin G Morris and Hugh S Markus
    Citation: BMC Medicine 2015 13:51
  8. Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease and related hospitalization of young children in least developed countries. Individuals are repeatedly infected, but it i...

    Authors: Piero Poletti, Stefano Merler, Marco Ajelli, Piero Manfredi, Patrick K Munywoki, D James Nokes and Alessia Melegaro
    Citation: BMC Medicine 2015 13:49
  9. Excess body weight is a major risk factor for cardiometabolic diseases. The complex molecular mechanisms of body weight change-induced metabolic perturbations are not fully understood. Specifically, in-depth m...

    Authors: Simone Wahl, Susanne Vogt, Ferdinand Stückler, Jan Krumsiek, Jörg Bartel, Tim Kacprowski, Katharina Schramm, Maren Carstensen, Wolfgang Rathmann, Michael Roden, Carolin Jourdan, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Ute Nöthlings, Heiner Boeing…
    Citation: BMC Medicine 2015 13:48
  10. Alcohol consumption patterns change across life and this is not fully captured in cross-sectional series data. Analysis of longitudinal data, with repeat alcohol measures, is necessary to reveal changes within...

    Authors: Annie Britton, Yoav Ben-Shlomo, Michaela Benzeval, Diana Kuh and Steven Bell
    Citation: BMC Medicine 2015 13:47
  11. The standard of care for patients with hormone receptor positive, human epidermal growth factor receptor type 2 negative advanced breast cancer is endocrine therapy. Endocrine agents, including aromatase inhib...

    Authors: Ilenia Migliaccio, Luca Malorni, Christopher D Hart, Cristina Guarducci and Angelo Di Leo
    Citation: BMC Medicine 2015 13:46
  12. The tumor microenvironment (TME) is being increasingly recognized as a key factor in multiple stages of disease progression, particularly local resistance, immune-escaping, and distant metastasis, thereby subs...

    Authors: Fei Chen, Xueqian Zhuang, Liangyu Lin, Pengfei Yu, Ying Wang, Yufang Shi, Guohong Hu and Yu Sun
    Citation: BMC Medicine 2015 13:45
  13. Global mental health is a relatively new field that has focused on disparities in mental health services across different settings, and on innovative ways to provide feasible, acceptable, and effective service...

    Authors: Dan J Stein and James Giordano
    Citation: BMC Medicine 2015 13:44
  14. Neuropsychiatric symptoms affect nearly half of the patients with systemic lupus erythematosus; however, the effect on disease severity, quality of life, and prognosis is tremendous. Symptoms of neuropsychiatr...

    Authors: Shaye Kivity, Nancy Agmon-Levin, Gisele Zandman-Goddard, Joab Chapman and Yehuda Shoenfeld
    Citation: BMC Medicine 2015 13:43
  15. The current epidemic of obesity and cardiometabolic diseases in developing countries is described as being driven by socioeconomic inequalities. These populations have a greater vulnerability to cardiometaboli...

    Authors: Patricio Lopez-Jaramillo, Diego Gomez-Arbelaez, Aristides Sotomayor-Rubio, Daniel Mantilla-Garcia and Jose Lopez-Lopez
    Citation: BMC Medicine 2015 13:41
  16. Urinary creatinine excretion is used as a marker of completeness of timed urine collections, which are a keystone of several metabolic evaluations in clinical investigations and epidemiological surveys.

    Authors: Valentina Forni Ogna, Adam Ogna, Philippe Vuistiner, Menno Pruijm, Belen Ponte, Daniel Ackermann, Luca Gabutti, Nima Vakilzadeh, Markus Mohaupt, Pierre-Yves Martin, Idris Guessous, Antoinette Péchère-Bertschi, Fred Paccaud, Murielle Bochud and Michel Burnier
    Citation: BMC Medicine 2015 13:40
  17. The association between single health behaviours and incidence of and premature mortality from major chronic diseases, including myocardial infarction, stroke, diabetes mellitus, and cancer, has been demonstra...

    Authors: Anne M May, Ellen A Struijk, Heidi P Fransen, N Charlotte Onland-Moret, G Ardine de Wit, Jolanda MA Boer, Yvonne T van der Schouw, Jeljer Hoekstra, H Bas Bueno-de-Mesquita, Petra HM Peeters and Joline WJ Beulens
    Citation: BMC Medicine 2015 13:39
  18. The smoking epidemic in Australia is characterised by historic levels of prolonged smoking, heavy smoking, very high levels of long-term cessation, and low current smoking prevalence, with 13% of adults report...

    Authors: Emily Banks, Grace Joshy, Marianne F Weber, Bette Liu, Robert Grenfell, Sam Egger, Ellie Paige, Alan D Lopez, Freddy Sitas and Valerie Beral
    Citation: BMC Medicine 2015 13:38
  19. Recently, we reported the findings of a randomized controlled trial on the effectiveness of Stepping Stones Triple P (SSTP) compared to Care as Usual (CAU), in BMC Medicine. The study involved parents of 209 chil...

    Authors: Sijmen A Reijneveld, Marijke Kleefman and Daniëlle EMC Jansen
    Citation: BMC Medicine 2015 13:36
  20. Heart failure represents a primary cause of morbidity and mortality in older people and despite significant therapeutic advances, it is still characterized by important unmet needs, thus remaining a challengin...

    Authors: Gerasimos Filippatos, Dimitrios Farmakis, John Parissis and John Lekakis
    Citation: BMC Medicine 2015 13:35
  21. The quality of reporting clinical and preclinical research is not optimal. Reporting guidelines can help make reports of research more complete and transparent, thus increasing their value and making them more...

    Authors: David Moher, Marc Avey, Gerd Antes and Douglas G Altman
    Citation: BMC Medicine 2015 13:34

    The Erratum to this article has been published in BMC Medicine 2015 13:80

  22. Many biomedical publications refer to data obtained from collections of biosamples. Sharing such bioresources (biological samples, data, and databases) is paramount for the present governance of research. Reco...

    Authors: Elena Bravo, Alessia Calzolari, Paola De Castro, Laurence Mabile, Federica Napolitani, Anna Maria Rossi and Anne Cambon-Thomsen
    Citation: BMC Medicine 2015 13:33
  23. Serum retinol concentration determined by high-performance liquid chromatography (HPLC) is recommended by the World Health Organization to assess population vitamin A status. This assay is expensive, technical...

    Authors: Elise F Talsma, Hans Verhoef, Inge D Brouwer, Anne S Mburu-de Wagt, Paul JM Hulshof and Alida Melse-Boonstra
    Citation: BMC Medicine 2015 13:30
  24. Some drugs eventually have to be removed from the market because of a negative benefit-to-harm ratio, including an excess of mortality. Drug safety is the result of multiple factors, commencing with how clinic...

    Authors: Joel Lexchin
    Citation: BMC Medicine 2015 13:27
  25. Post-marketing withdrawal of medicinal products because of deaths can be occasioned by evidence obtained from case reports, observational studies, randomized trials, or systematic reviews. There have been no s...

    Authors: Igho J Onakpoya, Carl J Heneghan and Jeffrey K Aronson
    Citation: BMC Medicine 2015 13:26
  26. Maternal smoking during pregnancy (MSDP) is associated with multiple adverse childhood outcomes including externalizing behaviors. However, the association between MSDP and internalizing (anxiety and depressiv...

    Authors: Steven Moylan, Kristin Gustavson, Simon Øverland, Evalill Bølstad Karevold, Felice N Jacka, Julie A Pasco and Michael Berk
    Citation: BMC Medicine 2015 13:24
  27. Severe anaemia in children is a leading cause of hospital admission and a major cause of mortality in sub-Saharan Africa, yet there are limited published data on blood transfusion in this vulnerable group.

    Authors: Sarah Kiguli, Kathryn Maitland, Elizabeth C George, Peter Olupot-Olupot, Robert O Opoka, Charles Engoru, Samuel O Akech, Richard Nyeko, George Mtove, Hugh Reyburn, Michael Levin, Abdel G Babiker, Diana M Gibb and Jane Crawley
    Citation: BMC Medicine 2015 13:21
  28. Diagnosis is the traditional basis for decision-making in clinical practice. Evidence is often lacking about future benefits and harms of these decisions for patients diagnosed with and without disease. We pro...

    Authors: Peter Croft, Douglas G Altman, Jonathan J Deeks, Kate M Dunn, Alastair D Hay, Harry Hemingway, Linda LeResche, George Peat, Pablo Perel, Steffen E Petersen, Richard D Riley, Ian Roberts, Michael Sharpe, Richard J Stevens, Danielle A Van Der Windt, Michael Von Korff…
    Citation: BMC Medicine 2015 13:20
  29. The identification of protective immune responses to P. falciparum infection is an important goal for the development of a vaccine for malaria. This requires the identification of susceptible and resistant indivi...

    Authors: Mykola Pinkevych, Kiprotich Chelimo, John Vulule, James W Kazura, Ann M Moormann and Miles P Davenport
    Citation: BMC Medicine 2015 13:19
  30. Maternal smoking is one of the most important modifiable risk factors for low birthweight, which is strongly associated with increased cardiometabolic disease risk in adulthood. Maternal smoking reduces the le...

    Authors: Amanda J Drake, Peter J O’Shaughnessy, Siladitya Bhattacharya, Ana Monteiro, David Kerrigan, Sven Goetz, Andrea Raab, Stewart M Rhind, Kevin D Sinclair, Andrew A Meharg, Jörg Feldmann and Paul A Fowler
    Citation: BMC Medicine 2015 13:18
  31. Malnourished HIV-infected African adults are at high risk of early mortality after starting antiretroviral therapy (ART). We hypothesized that short-course, high-dose vitamin and mineral supplementation in lip...

    Authors: Suzanne Filteau, George PrayGod, Lackson Kasonka, Susannah Woodd, Andrea M Rehman, Molly Chisenga, Joshua Siame, John R Koethe, John Changalucha, Denna Michael, Jeremiah Kidola, Daniela Manno, Natasha Larke, Daniel Yilma, Douglas C Heimburger, Henrik Friis…
    Citation: BMC Medicine 2015 13:17
  32. Blood volume and haemoglobin (Hb) levels are increased by delayed umbilical cord clamping, which has been reported to improve clinical outcomes of preterm infants. The objective was to determine whether Hb lev...

    Authors: Jayanta Banerjee, Felix K Asamoah, Devpriya Singhvi, Angela WG Kwan, Joan K Morris and Narendra Aladangady
    Citation: BMC Medicine 2015 13:16
  33. Easy-to-collect epidemiological information is critical for the more accurate estimation of the prevalence and burden of different non-communicable diseases around the world. Current measurement is restricted ...

    Authors: Spencer L James, Minerva Romero, Dolores Ramírez-Villalobos, Sara Gómez, Kelsey Pierce, Abraham Flaxman, Peter Serina, Andrea Stewart, Christopher JL Murray, Emmanuela Gakidou, Rafael Lozano and Bernardo Hernandez
    Citation: BMC Medicine 2015 13:15
  34. The majority of studies on quality of oral anticoagulation (OAC) therapy with vitamin K-antagonists are performed with short-acting warfarin. Data on long-acting phenprocoumon, which is frequently used in Euro...

    Authors: Jürgen H Prochaska, Sebastian Göbel, Karsten Keller, Meike Coldewey, Alexander Ullmann, Heidrun Lamparter, Claus Jünger, Zaid Al-Bayati, Christina Baer, Ulrich Walter, Christoph Bickel, Hugo ten Cate, Thomas Münzel and Philipp S Wild
    Citation: BMC Medicine 2015 13:14
  35. Recently, there has been both immense interest and controversy regarding a randomised, controlled trial which showed antibiotics to be effective in the treatment of chronic low back pain (disc herniation with ...

    Authors: Donna M Urquhart, Yiliang Zheng, Allen C Cheng, Jeffrey V Rosenfeld, Patrick Chan, Susan Liew, Sultana Monira Hussain and Flavia M Cicuttini
    Citation: BMC Medicine 2015 13:13
  36. The effects of lithium treatment on renal function have been previously shown, albeit with discrepancies regarding their relevance. In this study, we examined glomerular filtration rate in patients treated wit...

    Authors: Alberto Bocchetta, Raffaella Ardau, Tiziana Fanni, Claudia Sardu, Doloretta Piras, Antonello Pani and Maria Del Zompo
    Citation: BMC Medicine 2015 13:12