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  1. Content type: Research article

    Rates of emergency hospitalisations are increasing in many countries, leading to disruption in the quality of care and increases in cost. Therefore, identifying strategies to reduce emergency admission rates i...

    Authors: Niklas Bobrovitz, Carl Heneghan, Igho Onakpoya, Benjamin Fletcher, Dylan Collins, Alice Tompson, Joseph Lee, David Nunan, Rebecca Fisher, Brittney Scott, Jack O’Sullivan, Oliver Van Hecke, Brian D. Nicholson, Sarah Stevens, Nia Roberts and Kamal R. Mahtani

    Citation: BMC Medicine 2018 16:115

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    The Commentary to this article has been published in BMC Medicine 2018 16:169

  2. Content type: Research article

    Sub-Saharan Africa (SSA) continues to suffer high communicable disease burdens as its demographic transition (DT) proceeds. Although the consequent changes in population structures influence age-specific conta...

    Authors: John R. Williams, Piero Manfredi and Alessia Melegaro

    Citation: BMC Medicine 2018 16:118

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  3. Content type: Research article

    The presence of concomitant medical conditions in people with dementia is common. Dementia may be related to differential use of health, social and informal care.

    Authors: Holly Q. Bennett, Sam Norton, Frances Bunn, Louise Robinson, Greta Rait, Claire Goodman, Carol Brayne and Fiona E. Matthews

    Citation: BMC Medicine 2018 16:114

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  4. Content type: Research article

    Most evidence about what works in transitional care comes from small studies in single clinical specialties. We tested the hypothesis that exposures to nine recommended features of transitional healthcare were...

    Authors: A. Colver, H. McConachie, A. Le Couteur, G. Dovey-Pearce, K. D. Mann, J. E. McDonagh, M. S. Pearce, L. Vale, H. Merrick and J. R. Parr

    Citation: BMC Medicine 2018 16:111

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  5. Content type: Research article

    Depression is a prevalent and disabling mental disorder that frequently co-occurs with a wide range of chronic conditions. Evidence has suggested that depression could be associated with excess all-cause morta...

    Authors: Myrela O. Machado, Nicola Veronese, Marcos Sanches, Brendon Stubbs, Ai Koyanagi, Trevor Thompson, Ioanna Tzoulaki, Marco Solmi, Davy Vancampfort, Felipe B. Schuch, Michael Maes, Giovanni A. Fava, John P. A. Ioannidis and André F. Carvalho

    Citation: BMC Medicine 2018 16:112

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    The Commentary to this article has been published in BMC Medicine 2018 16:147

  6. Content type: Research article

    As complete reporting is essential to judge the validity and applicability of multivariable prediction models, a guideline for the Transparent Reporting of a multivariable prediction model for Individual Progn...

    Authors: Pauline Heus, Johanna A. A. G. Damen, Romin Pajouheshnia, Rob J. P. M. Scholten, Johannes B. Reitsma, Gary S. Collins, Douglas G. Altman, Karel G. M. Moons and Lotty Hooft

    Citation: BMC Medicine 2018 16:120

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  7. Content type: Research article

    Human papillomavirus (HPV) vaccination is safe and effective in preventing cervical cancer in females. As HPV infections can also induce cancers of the anus, penis and oral cavity, male vaccination is also adv...

    Authors: Thomas Harder, Ole Wichmann, Stefanie J. Klug, Marianne A. B. van der Sande and Miriam Wiese-Posselt

    Citation: BMC Medicine 2018 16:110

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  8. Content type: Research article

    The present study aims to evaluate the cost-effectiveness of the newly introduced varicella and herpes zoster (HZ) vaccination programmes in Italy. The appropriateness of the introduction of the varicella vacc...

    Authors: Alessia Melegaro, Valentina Marziano, Emanuele Del Fava, Piero Poletti, Marcello Tirani, Caterina Rizzo and Stefano Merler

    Citation: BMC Medicine 2018 16:117

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  9. Content type: Research article

    Intensification of metformin monotherapy with additional glucose-lowering drugs is often required in patients with type 2 diabetes (T2D). This study evaluated changes in HbA1c and weight, as well as treatment ...

    Authors: John Wilding, Thomas Godec, Kamlesh Khunti, Stuart Pocock, Robin Fox, Liam Smeeth, Per Clauson, Peter Fenici, Niklas Hammar and Jesús Medina

    Citation: BMC Medicine 2018 16:116

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  10. Content type: Research article

    The RTS,S/AS01 vaccine for Plasmodium falciparum malaria demonstrated moderate efficacy in 5–17-month-old children in phase 3 trials, and from 2018, the vaccine will be evaluated through a large-scale pilot imple...

    Authors: Alexandra B. Hogan, Peter Winskill, Robert Verity, Jamie T. Griffin and Azra C. Ghani

    Citation: BMC Medicine 2018 16:109

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  11. Content type: Research article

    Caregivers may promote the uptake of science into patient care and the practice of evidence-informed medicine. The purpose of this study was to determine whether caregiver-mediated (non-clinical caregiver-deli...

    Authors: Kirsten M. Fiest, Christiane Job McIntosh, Danielle Demiantschuk, Jeanna Parsons Leigh and Henry T. Stelfox

    Citation: BMC Medicine 2018 16:105

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  12. Content type: Research article

    For patients starting treatment for depression, current guidelines recommend titrating the antidepressant dosage to the maximum of the licenced range if tolerated. When patients do not achieve remission within...

    Authors: Tadashi Kato, Toshi A. Furukawa, Akio Mantani, Ken’ichi Kurata, Hajime Kubouchi, Susumu Hirota, Hirotoshi Sato, Kazuyuki Sugishita, Bun Chino, Kahori Itoh, Yoshio Ikeda, Yoshihiro Shinagawa, Masaki Kondo, Yasumasa Okamoto, Hirokazu Fujita, Motomu Suga…

    Citation: BMC Medicine 2018 16:103

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  13. Content type: Research article

    Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved.

    Authors: Nicholas L. Syn, Andrea Li-Ann Wong, Soo-Chin Lee, Hock-Luen Teoh, James Wei Luen Yip, Raymond CS Seet, Wee Tiong Yeo, William Kristanto, Ping-Chong Bee, LM Poon, Patrick Marban, Tuck Seng Wu, Michael D. Winther, Liam R. Brunham, Richie Soong, Bee-Choo Tai…

    Citation: BMC Medicine 2018 16:104

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  14. Content type: Research article

    The effects of community health worker (CHW) home visiting during the antenatal and postnatal periods in fragile- and conflicted-affected countries such as Afghanistan are not known.

    Authors: Karen M. Edmond, Khaksar Yousufi, Zelaikha Anwari, Sayed Masoud Sadat, Shah Mansoor Staniczai, Ariel Higgins-Steele, Alexandra L. Bellows and Emily R. Smith

    Citation: BMC Medicine 2018 16:106

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  15. Content type: Research article

    The Choosing Wisely campaign highlights the importance of clinical reasoning abilities for competent and reflective physicians. The principles of this campaign should be addressed in undergraduate medical educati...

    Authors: Sascha Ludwig, Nikolai Schuelper, Jamie Brown, Sven Anders and Tobias Raupach

    Citation: BMC Medicine 2018 16:107

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  16. Content type: Research article

    Stratification of cancer patients to identify those with worse prognosis is increasingly important. Through in silico analyses, we recently developed a gene expression-based prognostic score (S3-score) for cle...

    Authors: Florian Büttner, Stefan Winter, Steffen Rausch, Jörg Hennenlotter, Stephan Kruck, Arnulf Stenzl, Marcus Scharpf, Falko Fend, Abbas Agaimy, Arndt Hartmann, Jens Bedke, Matthias Schwab and Elke Schaeffeler

    Citation: BMC Medicine 2018 16:108

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  17. Content type: Research article

    Equitable access to vaccines has been suggested as a priority for low- and middle-income countries (LMICs). However, it is unclear whether providing equitable access is enough to ensure health equity. Furtherm...

    Authors: Angela Y. Chang, Carlos Riumallo-Herl, Joshua A. Salomon, Stephen C. Resch, Logan Brenzel and Stéphane Verguet

    Citation: BMC Medicine 2018 16:102

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  18. Content type: Research article

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a worldwide prevalence of 1–2%. In low-resource environments, in particular, early identification and diagnosis is a significant challenge. ...

    Authors: T. Heunis, C. Aldrich, J. M. Peters, S. S. Jeste, M. Sahin, C. Scheffer and P. J. de Vries

    Citation: BMC Medicine 2018 16:101

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  19. Content type: Research article

    The Mediterranean Diet (MedDiet) has been acknowledged as a healthy diet. However, its relation with risk of major chronic diseases in non-Mediterranean countries is inconclusive. The Nordic diet is proposed a...

    Authors: Cecilia Galbete, Janine Kröger, Franziska Jannasch, Khalid Iqbal, Lukas Schwingshackl, Carolina Schwedhelm, Cornelia Weikert, Heiner Boeing and Matthias B. Schulze

    Citation: BMC Medicine 2018 16:99

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  20. Content type: Correspondence

    Malaria at international borders presents particular challenges with regards to elimination. International borders share common malaria ecologies, yet neighboring countries are often at different stages of the...

    Authors: Mohammed H. Al Zahrani, Abdiasiis I. Omar, Abdelmohsin M. O. Abdoon, Ali Adam Ibrahim, Abdullah Alhogail, Mohamed Elmubarak, Yousif Eldirdiry Elamin, Mohammed A. AlHelal, Ali M. Alshahrani, Tarig M. Abdelgader, Ibrahim Saeed, Tageddin B. El Gamri, Mohammed S. Alattas, Abdu A. Dahlan, Abdullah M. Assiri, Joseph Maina…

    Citation: BMC Medicine 2018 16:98

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  21. Content type: Research article

    Globally, illness and life expectancy follow a social gradient that puts people of lower socioeconomic status (SES) at higher risk of dying prematurely. Alcohol consumption has been shown to be a factor contri...

    Authors: Charlotte Probst, Charles D. H. Parry, Hans-Ulrich Wittchen and Jürgen Rehm

    Citation: BMC Medicine 2018 16:97

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  22. Content type: Opinion

    The healthcare system has proved a challenging environment for innovation, especially in the area of health services management and research. This is often attributed to the complexity of the healthcare sector...

    Authors: Katrina M. Long, Fiona McDermott and Graham N. Meadows

    Citation: BMC Medicine 2018 16:94

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  23. Content type: Research article

    Despite limited information on neonatal safety, the transfer of frozen-thawed cleavage-stage embryos with blastomere loss is common in women undergoing in vitro fertilization. We aimed to evaluate the pregnanc...

    Authors: Yan-Ting Wu, Cheng Li, Yi-Min Zhu, Shu-Hua Zou, Qiong-Fang Wu, Li-Ping Wang, Yan Wu, Rong Yin, Chao-Yi Shi, Jing Lin, Zi-Ru Jiang, Yi-Jing Xu, Yun-Fei Su, Jian Zhang, Jian-Zhong Sheng, William D. Fraser…

    Citation: BMC Medicine 2018 16:96

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  24. Content type: Research article

    Existing evidence remains inconclusive as to the association between chronic hepatitis B virus (HBV) infection and the risk of chronic kidney disease (CKD). We prospectively examined the association between ch...

    Authors: Jiahui Si, Canqing Yu, Yu Guo, Zheng Bian, Chenxi Qin, Ling Yang, Yiping Chen, Li Yin, Hui Li, Jian Lan, Junshi Chen, Zhengming Chen, Jun Lv and Liming Li

    Citation: BMC Medicine 2018 16:93

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  25. Content type: Debate

    More than 65 million persons are currently forcibly displaced, of whom more than 22 million are refugees. Conflicts are increasing, and existing ones are becoming more protracted; a refugee remains a refugee f...

    Authors: Paul Spiegel, Rebecca Chanis and Antonio Trujillo

    Citation: BMC Medicine 2018 16:90

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  26. Content type: Research article

    Media depictions and laws passed in state legislatures regulating abortion suggest abortion-related medical emergencies are common. An accurate understanding of abortion-related emergencies is important for in...

    Authors: Ushma D. Upadhyay, Nicole E. Johns, Rebecca Barron, Alice F. Cartwright, Chantal Tapé, Alyssa Mierjeski and Alyson J. McGregor

    Citation: BMC Medicine 2018 16:88

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  27. Content type: Research article

    Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable outcomes. Optimising care for polypharmacy necessita...

    Authors: Jenni Burt, Natasha Elmore, Stephen M. Campbell, Sarah Rodgers, Anthony J. Avery and Rupert A. Payne

    Citation: BMC Medicine 2018 16:91

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  28. Content type: Research article

    Global migration is at an all-time high with implications for perinatal health. Migrant women, especially asylum seekers and refugees, represent a particularly vulnerable group. Understanding the impact on the...

    Authors: Nicola Heslehurst, Heather Brown, Augustina Pemu, Hayley Coleman and Judith Rankin

    Citation: BMC Medicine 2018 16:89

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  29. Content type: Research article

    Inadequate planning, selective reporting, and incomplete reporting of outcomes in randomized controlled trials (RCTs) contribute to the problem of waste of research. We aimed to describe such a waste and to ex...

    Authors: Youri Yordanov, Agnes Dechartres, Ignacio Atal, Viet-Thi Tran, Isabelle Boutron, Perrine Crequit and Philippe Ravaud

    Citation: BMC Medicine 2018 16:87

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  30. Content type: Research article

    In the earlier randomized controlled Physical Activity during Cancer Treatment (PACT) study, we found beneficial effects of an 18-week supervised exercise program on fatigue in patients with newly diagnosed br...

    Authors: Lenja Witlox, Anouk E. Hiensch, Miranda J. Velthuis, Charlotte N. Steins Bisschop, Maartje Los, Frans L. G. Erdkamp, Haiko J. Bloemendal, Marlies Verhaar, Daan ten Bokkel Huinink, Elsken van der Wall, Petra H. M. Peeters and Anne M. May

    Citation: BMC Medicine 2018 16:86

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  31. Content type: Research article

    HIV increases the progression of latent tuberculosis (TB) infection to active disease and contributed to increased TB in the UK until 2004. We describe temporal trends in HIV infection amongst patients with TB...

    Authors: Joanne R. Winter, Helen R. Stagg, Colette J. Smith, Maeve K. Lalor, Jennifer A. Davidson, Alison E. Brown, James Brown, Dominik Zenner, Marc Lipman, Anton Pozniak, Ibrahim Abubakar and Valerie Delpech

    Citation: BMC Medicine 2018 16:85

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  32. Content type: Opinion

    Various Zika virus (ZIKV) vaccine candidates are currently in development. Nevertheless, unique challenges in clinical development and regulatory pathways may hinder the licensure of high-quality, safe, and ef...

    Authors: Annelies Wilder-Smith, Kirsten Vannice, Anna Durbin, Joachim Hombach, Stephen J. Thomas, Irani Thevarjan and Cameron P. Simmons

    Citation: BMC Medicine 2018 16:84

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  33. Content type: Minireview

    In real-world clinical practice, the acceptance of anticoagulation therapy in the management of portal vein thrombosis (PVT) in patients with cirrhosis is limited by the fear of an increased bleeding risk. Add...

    Authors: Xingshun Qi, Xiaozhong Guo, Eric M. Yoshida, Nahum Méndez-Sánchez, Valerio De Stefano, Frank Tacke, Andrea Mancuso, Yasuhiko Sugawara, Sien-Sing Yang, Rolf Teschke, Ankur Arora and Dominique-Charles Valla

    Citation: BMC Medicine 2018 16:83

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  34. Content type: Commentary

    The increasing number and global distribution of pathogens resistant to antimicrobial drugs is potentially one of the greatest threats to global health, leading to health crises arising from infections that we...

    Authors: Simon I. Hay, Puja C. Rao, Christiane Dolecek, Nicholas P. J. Day, Andy Stergachis, Alan D. Lopez and Christopher J. L. Murray

    Citation: BMC Medicine 2018 16:78

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  35. Content type: Research article

    Despite decades of experience with praziquantel treatment in school-aged children (SAC) and adults, we still face considerable knowledge gaps relevant to the successful treatment of preschool-aged children (PS...

    Authors: Jean T. Coulibaly, Gordana Panic, Richard B. Yapi, Jana Kovač, Beatrice Barda, Yves K. N’Gbesso, Jan Hattendorf and Jennifer Keiser

    Citation: BMC Medicine 2018 16:81

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  36. Content type: Research article

    Innovative ways of delivering care are needed to improve outcomes for older people with multimorbidity. Health coaching involves ‘a regular series of phone calls between patient and health professional to prov...

    Authors: Maria Panagioti, David Reeves, Rachel Meacock, Beth Parkinson, Karina Lovell, Mark Hann, Kelly Howells, Amy Blakemore, Lisa Riste, Peter Coventry, Thomas Blakeman, Mark Sidaway and Peter Bower

    Citation: BMC Medicine 2018 16:80

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  37. Content type: Research article

    The CD4/CD8 ratio has been associated with the risk of AIDS and non-AIDS events. We describe trends in immunological parameters in people who underwent a switch to monotherapy or dual therapy, compared to a co...

    Authors: Cristina Mussini, Patrizia Lorenzini, Alessandro Cozzi-Lepri, Giulia Marchetti, Stefano Rusconi, Andrea Gori, Silvia Nozza, Miriam Lichtner, Andrea Antinori, Andrea Cossarizza and Antonella d’Arminio Monforte

    Citation: BMC Medicine 2018 16:79

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  38. Content type: Research article

    The relationship between long-term exposure to whole body or central obesity and cognitive function, as well as its potential determinants, remain controversial. In this study, we assessed (1) the potential im...

    Authors: Stefano Masi, Georgios Georgiopoulos, Tauseef Khan, William Johnson, Andrew Wong, Marietta Charakida, Peter Whincup, Alun D. Hughes, Marcus Richards, Rebecca Hardy and John Deanfield

    Citation: BMC Medicine 2018 16:75

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  39. Content type: Research article

    The appropriate limit to the amount of daily sedentary time (ST) required to minimize mortality is uncertain. This meta-analysis aimed to quantify the dose-response association between daily ST and all-cause m...

    Authors: Po-Wen Ku, Andrew Steptoe, Yung Liao, Ming-Chun Hsueh and Li-Jung Chen

    Citation: BMC Medicine 2018 16:74

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  40. Content type: Research article

    Discretionary screen time (time spent viewing a television or computer screen during leisure time) is an important contributor to total sedentary behaviour, which is associated with increased risk of mortality...

    Authors: Carlos A. Celis-Morales, Donald M. Lyall, Lewis Steell, Stuart R. Gray, Stamatina Iliodromiti, Jana Anderson, Daniel F. Mackay, Paul Welsh, Thomas Yates, Jill P. Pell, Naveed Sattar and Jason M. R. Gill

    Citation: BMC Medicine 2018 16:77

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  41. Content type: Research article

    Reliable measures of disease burden over time are necessary to evaluate the impact of interventions and assess sub-national trends in the distribution of infection. Three Malaria Indicator Surveys (MISs) have ...

    Authors: Su Yun Kang, Katherine E. Battle, Harry S. Gibson, Arsène Ratsimbasoa, Milijaona Randrianarivelojosia, Stéphanie Ramboarina, Peter A. Zimmerman, Daniel J. Weiss, Ewan Cameron, Peter W. Gething and Rosalind E. Howes

    Citation: BMC Medicine 2018 16:71

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  42. Content type: Research article

    Effective coverage requires that those in need can access skilled care supported by adequate resources. There are, however, few studies of effective coverage of facility-based neonatal care in low-income setti...

    Authors: Georgina A. V. Murphy, David Gathara, Jacintah Mwachiro, Nancy Abuya, Jalemba Aluvaala and Mike English

    Citation: BMC Medicine 2018 16:72

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  43. Content type: Research article

    Chest radiographs are used for diagnosis and severity assessment in tuberculosis (TB). The extent of disease as determined by smear grade and cavitation as a binary measure can predict 2-month smear results, b...

    Authors: S. E. Murthy, F. Chatterjee, A. Crook, R. Dawson, C. Mendel, M. E. Murphy, S. R. Murray, A. J. Nunn, P. P. J. Phillips, Kasha P. Singh, T. D. McHugh and S. H. Gillespie

    Citation: BMC Medicine 2018 16:73

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