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  1. ACE2 is a novel homologue of angiotensin converting enzyme (ACE). ACE2 is highly expressed in human heart and animal data suggest that ACE2 is an essential regulator of cardiac function in vivo. Since overactivit...

    Authors: Andrew B Goulter, Martin J Goddard, Jennifer C Allen and Kenneth L Clark
    Citation: BMC Medicine 2004 2:19
  2. To empirically evaluate bias in estimation of accuracy associated with delay in verification of diagnosis among studies evaluating tests for predicting endometrial hyperplasia.

    Authors: T Justin Clark, Gerben ter Riet, Aravinthan Coomarasamy and Khalid S Khan
    Citation: BMC Medicine 2004 2:18
  3. The purpose of the present study was to continue the investigation of the membrane transport mechanisms of 20-(S)-camptothecin (CPT) in order to understand the possible role of membrane transporters on its ora...

    Authors: Anita K Lalloo, Feng R Luo, Ailan Guo, Pankaj V Paranjpe, Sung-Hack Lee, Viral Vyas, Eric Rubin and Patrick J Sinko
    Citation: BMC Medicine 2004 2:16
  4. An intravenous urogram (IVU) has traditionally been considered mandatory before treating renal and ureteric stones by extracorporeal shock wave lithotripsy (ESWL). This study was designed to see whether there ...

    Authors: M Hammad Ather, Nuzhat Faruqui, Sobia Akhtar and M Nasir Sulaiman
    Citation: BMC Medicine 2004 2:15
  5. Recent studies in children have demonstrated that frequent occurrence of parasomnias is related to increased sleep disruption, mental disorders, physical harm, sleep disordered breathing, and parental duress. ...

    Authors: James L Goodwin, Kris L Kaemingk, Ralph F Fregosi, Gerald M Rosen, Wayne J Morgan, Terry Smith and Stuart F Quan
    Citation: BMC Medicine 2004 2:14
  6. Understanding variations in the incidence of schizophrenia is a crucial step in unravelling the aetiology of this group of disorders. The aims of this review are to systematically identify studies related to t...

    Authors: John McGrath, Sukanta Saha, Joy Welham, Ossama El Saadi, Clare MacCauley and David Chant
    Citation: BMC Medicine 2004 2:13
  7. Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum ...

    Authors: Terry O Herndon, Salvador Gonzalez, TR Gowrishankar, R Rox Anderson and James C Weaver
    Citation: BMC Medicine 2004 2:12
  8. Despite treatment recommendations from various organizations, oral rehydration therapy (ORT) continues to be underused, particularly by physicians in high-income countries. We conducted a systematic review of ...

    Authors: Steven Bellemare, Lisa Hartling, Natasha Wiebe, Kelly Russell, William R Craig, Don McConnell and Terry P Klassen
    Citation: BMC Medicine 2004 2:11
  9. We have previously described an alternative invasion-independent pathway of cancer metastasis in a murine mammary tumor model. This pathway is initiated by intravasation of tumor nests enveloped by endothelial...

    Authors: Takashi Sugino, Tomiko Yamaguchi, Go Ogura, Atsuko Saito, Takeaki Hashimoto, Nobuo Hoshi, Sayaka Yoshida, Steve Goodison and Toshimitsu Suzuki
    Citation: BMC Medicine 2004 2:9
  10. The ABC transporter P-glycoprotein (P-gp) is recognized as a site for drug-drug interactions and provides a mechanistic explanation for clinically relevant pharmacokinetic interactions with digoxin. The questi...

    Authors: Gunilla Englund, Pär Hallberg, Per Artursson, Karl Michaëlsson and Håkan Melhus
    Citation: BMC Medicine 2004 2:8
  11. Henoch Schönlein Purpura (HSP) is the most common systemic vasculitis of childhood. There is considerable controversy over whether children with HSP should be treated with corticosteroids. The goal of this stu...

    Authors: Adam M Huber, Jim King, Peter McLaine, Terry Klassen and Mary Pothos
    Citation: BMC Medicine 2004 2:7
  12. Randomized controlled trials comparing different vasectomy occlusion techniques are lacking. Thus, this multicenter randomized trial was conducted to compare the probability of the success of ligation and exci...

    Authors: David Sokal, Belinda Irsula, Melissa Hays, Mario Chen-Mok and Mark A Barone
    Citation: BMC Medicine 2004 2:6
  13. Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessiv...

    Authors: Eric L Klett, Kangmo Lu, Astrid Kosters, Edwin Vink, Mi-Hye Lee, Michael Altenburg, Sarah Shefer, Ashok K Batta, Hongwei Yu, Jianliang Chen, Richard Klein, Norbert Looije, Ronald Oude-Elferink, Albert K Groen, Nobuyo Maeda, Gerald Salen…
    Citation: BMC Medicine 2004 2:5
  14. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) have neuroprotective effects in experimental stroke models and are commonly prescribed in clinical practice. The aim of this study was to de...

    Authors: Sung Sug Yoon, James Dambrosia, Julio Chalela, Mustapha Ezzeddine, Steven Warach, Joseph Haymore, Lisa Davis and Alison E Baird
    Citation: BMC Medicine 2004 2:4
  15. The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease. Migraine, with and with...

    Authors: Rod A Lea, Micky Ovcaric, James Sundholm, John MacMillan and Lyn R Griffiths
    Citation: BMC Medicine 2004 2:3
  16. Abnormalities in limbic structures have been implicated in major depressive disorder (MDD). Although MDD is as common in adolescence as in adulthood, few studies have examined youth near illness onset in order...

    Authors: Frank P MacMaster and Vivek Kusumakar
    Citation: BMC Medicine 2004 2:2
  17. The British STRATIFY tool was previously developed to predict falls in hospital. Although the tool has several strengths, certain limitations exist which may not allow generalizability to a Canadian setting. T...

    Authors: Alexandra Papaioannou, William Parkinson, Richard Cook, Nicole Ferko, Esther Coker and Jonathan D Adachi
    Citation: BMC Medicine 2004 2:1
  18. This systematic review with meta-analysis was designed to evaluate the literature and to develop recommendations regarding the use of preoperative radiotherapy in the management of patients with resectable rec...

    Authors: Alvaro Figueredo, Lisa Zuraw, Rebecca KS Wong, Olusegun Agboola, R Bryan Rumble and Ved Tandan
    Citation: BMC Medicine 2003 1:1