Skip to main content

Articles

Page 2 of 61

  1. The high degree of heterogeneity brought great challenges to the diagnosis and treatment of acute myeloid leukemia (AML). Although several different AML prognostic scoring models have been proposed to assess t...

    Authors: Tiansheng Zeng, Longzhen Cui, Wenhui Huang, Yan Liu, Chaozeng Si, Tingting Qian, Cong Deng and Lin Fu

    Citation: BMC Medicine 2021 19:176

    Content type: Research article

    Published on:

  2. The differential effect of pre-pregnancy low BMI on macrosomia has not been fully addressed. Herein, we conducted a city-wide population-based cohort study to illuminate the association between pre-pregnancy l...

    Authors: Guoju Li, Yuhan Xing, Guolan Wang, Jun Zhang, Qin Wu, Wei Ni, Na Jiao, Wenjing Chen, Qing Liu, Li Gao, Zhenhong Zhang, Yao Wang and Quansheng Xing

    Citation: BMC Medicine 2021 19:175

    Content type: Research article

    Published on:

  3. The risk for several common cancers is influenced by the transcriptomic landscape of the respective tissue-of-origin. Vitamin D influences in vitro gene expression and cancer cell growth. We sought to determin...

    Authors: P. G. Vaughan-Shaw, G. Grimes, J. P. Blackmur, M. Timofeeva, M. Walker, L. Y. Ooi, Victoria Svinti, Kevin Donnelly, F. V. N. Din, S. M. Farrington and M. G. Dunlop

    Citation: BMC Medicine 2021 19:174

    Content type: Research article

    Published on:

  4. Glucocorticoids could theoretically decrease breast cancer risk through their anti-inflammatory effects or increase risk through immunosuppression. However, epidemiological evidence is limited regarding the as...

    Authors: Manon Cairat, Marie Al Rahmoun, Marc J. Gunter, Pierre-Etienne Heudel, Gianluca Severi, Laure Dossus and Agnès Fournier

    Citation: BMC Medicine 2021 19:186

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2021 19:187

  5. Circulating vitamin C concentrations have been associated with several cancers in observational studies, but little is known about the causal direction of the associations. This study aims to explore the poten...

    Authors: Yuanqing Fu, Fengzhe Xu, Longda Jiang, Zelei Miao, Xinxiu Liang, Jian Yang, Susanna C. Larsson and Ju-Sheng Zheng

    Citation: BMC Medicine 2021 19:171

    Content type: Research article

    Published on:

  6. All-cause mortality following atrial fibrillation (AF) has decreased over time. Data regarding temporal trends in causes of death among individuals with AF are scarce. The aim of our study was to analyze tempo...

    Authors: Jelena Kornej, Qiuxi Huang, Sarah R. Preis, Steven A. Lubitz, Darae Ko, Joanne M. Murabito, Emelia J. Benjamin and Ludovic Trinquart

    Citation: BMC Medicine 2021 19:170

    Content type: Research article

    Published on:

  7. The rapid process of research and development and lack of follow-up time post-vaccination aroused great public concern about the safety profile of COVID-19 vaccine candidates. To provide comprehensive overview...

    Authors: Qianhui Wu, Matthew Z. Dudley, Xinghui Chen, Xufang Bai, Kaige Dong, Tingyu Zhuang, Daniel Salmon and Hongjie Yu

    Citation: BMC Medicine 2021 19:173

    Content type: Research article

    Published on:

  8. In 2011, the World Health Organization recommended injectable artesunate as the first-line therapy for severe malaria (SM) due to its superiority in reducing mortality compared to quinine. There are limited da...

    Authors: Andrea L. Conroy, Robert O. Opoka, Paul Bangirana, Ruth Namazzi, Allen E. Okullo, Michael K. Georgieff, Sarah Cusick, Richard Idro, John M. Ssenkusu and Chandy C. John

    Citation: BMC Medicine 2021 19:168

    Content type: Research article

    Published on:

  9. Light-to-moderate alcohol consumption has been reported to be cardio-protective among apparently healthy individuals; however, it is unclear whether this association is also present in those with disease. To e...

    Authors: Chengyi Ding, Dara O’Neill, Steven Bell, Emmanuel Stamatakis and Annie Britton

    Citation: BMC Medicine 2021 19:167

    Content type: Research article

    Published on:

  10. The global pandemic of coronavirus disease 2019 (COVID-19) is caused by infection with the SARS-CoV-2 virus. Currently, there are three approved vaccines against SARS-CoV-2 in the USA, including two based on m...

    Authors: Elizabeth Fraley, Cas LeMaster, Eric Geanes, Dithi Banerjee, Santosh Khanal, Elin Grundberg, Rangaraj Selvarangan and Todd Bradley

    Citation: BMC Medicine 2021 19:169

    Content type: Research article

    Published on:

  11. Multiple omics technologies are increasingly applied to detect early, subtle molecular responses to environmental stressors for future disease risk prevention. However, there is an urgent need for further eval...

    Authors: Marta Gallego-Paüls, Carles Hernández-Ferrer, Mariona Bustamante, Xavier Basagaña, Jose Barrera-Gómez, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, John Wright, Remy Slama, Barbara Heude, Maribel Casas, Regina Grazuleviciene, Leda Chatzi, Eva Borràs…

    Citation: BMC Medicine 2021 19:166

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2021 19:210

  12. Immune checkpoint inhibitor (ICI) therapy elicits durable antitumor responses in patients with many types of cancer. Genomic mutations may be used to predict the clinical benefits of ICI therapy. NOTCH homolog...

    Authors: Junyu Long, Dongxu Wang, Xu Yang, Anqiang Wang, Yu Lin, Mingjun Zheng, Haohai Zhang, Xinting Sang, Hanping Wang, Ke Hu and Haitao Zhao

    Citation: BMC Medicine 2021 19:154

    Content type: Research article

    Published on:

  13. Environmental factors are associated with human longevity, but their specificity and causality remain mostly unclear. By integrating the innovative “exposome” concept developed in the field of environmental ep...

    Authors: Shu-Yi Huang, Yu-Xiang Yang, Shi-Dong Chen, Hong-Qi Li, Xue-Qing Zhang, Kevin Kuo, Lan Tan, Lei Feng, Qiang Dong, Can Zhang and Jin-Tai Yu

    Citation: BMC Medicine 2021 19:150

    Content type: Research article

    Published on:

  14. Randomized controlled trials have shown a higher sensitivity and longer negative predictive value of high-risk human papillomavirus (HPV) testing than cytology for cervical cancer screening; however, little is...

    Authors: Yanxia Zhao, Heling Bao, Lan Ma, Bo Song, Jiangli Di, Linhong Wang, Yanqiu Gao, Wenhui Ren, Shi Wang, Hai-Jun Wang and Jiuling Wu

    Citation: BMC Medicine 2021 19:164

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2021 19:165

  15. Few studies had described the health consequences of patients with coronavirus disease 2019 (COVID-19) especially in those with severe infections after discharge from hospital. Moreover, no research had report...

    Authors: Lijuan Xiong, Qian Li, Xiongjing Cao, Huangguo Xiong, Ming Huang, Fengwen Yang, Qingquan Liu, Daquan Meng, Mei Zhou, Gang Wang, Jun Tong, Tengfei Chen, Yanzhao Zhang, Xinliang He, Yunzhou Fan, Yupeng Zhang…

    Citation: BMC Medicine 2021 19:163

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2021 19:200

  16. Periodontitis is among the most common chronic diseases worldwide, and it is one of the main reasons for tooth loss. Comprehensive profiling of the metabolite content of the saliva can enable the identificatio...

    Authors: Leonie Andörfer, Birte Holtfreter, Stefan Weiss, Rutger Matthes, Vinay Pitchika, Carsten Oliver Schmidt, Stefanie Samietz, Gabi Kastenmüller, Matthias Nauck, Uwe Völker, Henry Völzke, Laszlo N. Csonka, Karsten Suhre, Maik Pietzner and Thomas Kocher

    Citation: BMC Medicine 2021 19:161

    Content type: Research article

    Published on:

  17. When three SARS-CoV-2 vaccines came to market in Europe and North America in the winter of 2020–2021, distribution networks were in a race against a major epidemiological wave of SARS-CoV-2 that began in autum...

    Authors: Thu Nguyen-Anh Tran, Nathan B. Wikle, Emmy Albert, Haider Inam, Emily Strong, Karel Brinda, Scott M. Leighow, Fuhan Yang, Sajid Hossain, Justin R. Pritchard, Philip Chan, William P. Hanage, Ephraim M. Hanks and Maciej F. Boni

    Citation: BMC Medicine 2021 19:162

    Content type: Research article

    Published on:

  18. Appropriate passive-active immunoprophylaxis effectively reduces mother-to-child transmission (MTCT) of hepatitis B virus (HBV), but the immunoprophylaxis failure was still more than 5% under the current strat...

    Authors: Xiaohui Zhang, Huaibin Zou, Yu Chen, Hua Zhang, Ruihua Tian, Jun Meng, Yunxia Zhu, Huimin Guo, Erhei Dai, Baoshen Zhu, Zhongsheng Liu, Yanxia Jin, Yujie Li, Liping Feng, Hui Zhuang, Calvin Q. Pan…

    Citation: BMC Medicine 2021 19:148

    Content type: Research article

    Published on:

  19. East Africa is home to 170 million people and prone to frequent outbreaks of viral haemorrhagic fevers and various bacterial diseases. A major challenge is that epidemics mostly happen in remote areas, where i...

    Authors: Muna Affara, Hakim Idris Lagu, Emmanuel Achol, Richard Karamagi, Neema Omari, Grace Ochido, Eric Kezakarayagwa, Francine Kabatesi, Anatole Nkeshimana, Abdi Roba, Millicent Nyakio Ndia, Mamo U. Abudo, Alice Kabanda, Etienne Mpabuka, Emil Ivan Mwikarago, Philip Ezekiel Kutjok…

    Citation: BMC Medicine 2021 19:160

    Content type: Correspondence

    Published on:

  20. Myasthenia gravis (MG) is an acquired immune-mediated disorder of the neuromuscular junction that causes fluctuating skeletal muscle weakness and fatigue. Pediatric MG and adult MG have many different characte...

    Authors: Peng Liu, Yiqi Jiang, Shanshan Gu, Yinping Xue, Hongxia Yang, Yongzhao Li, Yaxuan Wang, Congya Yan, Pei Jia, Xiaoting Lin and Guoyan Qi

    Citation: BMC Medicine 2021 19:159

    Content type: Research article

    Published on:

  21. Adherence to a healthy lifestyle could reduce the cancer mortality in the western population. We conducted a city-wide prospective study in China investigating the association of a healthy lifestyle score with...

    Authors: Ce Sun, Ke Li, Huan Xu, Xiangjun Wang, Pengzhe Qin, Suixiang Wang, Boheng Liang and Lin Xu

    Citation: BMC Medicine 2021 19:158

    Content type: Research article

    Published on:

  22. The validity of observational studies and their meta-analyses is contested. Here, we aimed to appraise thousands of meta-analyses of observational studies using a pre-specified set of quantitative criteria tha...

    Authors: Perrine Janiaud, Arnav Agarwal, Ioanna Tzoulaki, Evropi Theodoratou, Konstantinos K. Tsilidis, Evangelos Evangelou and John P. A. Ioannidis

    Citation: BMC Medicine 2021 19:157

    Content type: Research article

    Published on:

  23. Lung function is constantly changing over the life course. Although the relation of cross-sectional lung function measure and adverse outcomes has been reported, data on longitudinal change and subsequent card...

    Authors: Yun-Jiu Cheng, Zhen-Guang Chen, Zhu-Yu Li, Wei-Yi Mei, Wen-Tao Bi and Dong-Ling Luo

    Citation: BMC Medicine 2021 19:153

    Content type: Research article

    Published on:

  24. Disparities in health by adult income are well documented, but we know less about the childhood origins of health inequalities, and it remains unclear how the shape of the gradient varies across health conditi...

    Authors: Miriam Evensen, Søren Toksvig Klitkou, Mette C. Tollånes, Simon Øverland, Torkild Hovde Lyngstad, Stein Emil Vollset and Jonas Minet Kinge

    Citation: BMC Medicine 2021 19:152

    Content type: Research article

    Published on:

  25. Rotavirus infection has been proposed as a risk factor for coeliac disease (CD) and type 1 diabetes (T1D). The UK introduced infant rotavirus vaccination in 2013. We have previously shown that rotavirus vaccin...

    Authors: Thomas Inns, Kate M. Fleming, Miren Iturriza-Gomara and Daniel Hungerford

    Citation: BMC Medicine 2021 19:147

    Content type: Research article

    Published on:

  26. We assessed the duration and baseline determinants of antibody responses to SARS-CoV-2 spike antigens and the occurrence of reinfections in a prospective cohort of 173 Spanish primary health care worker patien...

    Authors: Carlota Dobaño, Anna Ramírez-Morros, Selena Alonso, Josep Vidal-Alaball, Gemma Ruiz-Olalla, Marta Vidal, Rocío Rubio, Emma Cascant, Daniel Parras, Natalia Rodrigo Melero, Pau Serra, Carlo Carolis, Pere Santamaria, Anna Forcada, Jacobo Mendioroz, Ruth Aguilar…

    Citation: BMC Medicine 2021 19:155

    Content type: Correspondence

    Published on:

    The Commentary to this article has been published in BMC Medicine 2021 19:200

  27. Since 2002, paramedics have been working in primary care within the United Kingdom (UK), a transition also mirrored within Australia, Canada and the USA. Recent recommendations to improve UK NHS workforce capa...

    Authors: Georgette Eaton, Geoff Wong, Stephanie Tierney, Nia Roberts, Veronika Williams and Kamal R. Mahtani

    Citation: BMC Medicine 2021 19:145

    Content type: Research article

    Published on:

  28. Pneumonia, diarrhoea and malaria are responsible for over one third of all deaths in children under the age of 5 years in low and middle sociodemographic index countries; many of these deaths are also associat...

    Authors: Peter Winskill, Alexandra B. Hogan, Julie Thwing, Lazaro Mwandigha, Patrick G. T. Walker and Ben Lambert

    Citation: BMC Medicine 2021 19:144

    Content type: Research article

    Published on:

  29. Clinically vulnerable individuals have been advised to shield themselves during the COVID-19 epidemic. The objectives of this study were to investigate (1) the rate ratio of severe COVID-19 associated with eli...

    Authors: Paul M. McKeigue, David A. McAllister, David Caldwell, Ciara Gribben, Jen Bishop, Stuart McGurnaghan, Matthew Armstrong, Joke Delvaux, Sam Colville, Sharon Hutchinson, Chris Robertson, Nazir Lone, Jim McMenamin, David Goldberg and Helen M. Colhoun

    Citation: BMC Medicine 2021 19:149

    Content type: Research article

    Published on:

  30. International dietary guidelines aim to reduce risks of all-cause mortality, cardiovascular disease (CVD), and fatal CVD often associated with poor dietary habits. However, most studies have examined associati...

    Authors: Maryam Kebbe, Min Gao, Aurora Perez-Cornago, Susan A. Jebb and Carmen Piernas

    Citation: BMC Medicine 2021 19:134

    Content type: Research article

    Published on:

  31. Current evidence from randomized controlled trials on statins for primary prevention of cardiovascular disease (CVD) in older people, especially those aged > 75 years, is still lacking. We conducted a systemat...

    Authors: Kamal Awad, Maged Mohammed, Mahmoud Mohamed Zaki, Abdelrahman I. Abushouk, Gregory Y. H. Lip, Michael J. Blaha, Carl J. Lavie, Peter P. Toth, J. Wouter Jukema, Naveed Sattar and Maciej Banach

    Citation: BMC Medicine 2021 19:139

    Content type: Research article

    Published on:

  32. As in many countries, quantifying COVID-19 spread in Indonesia remains challenging due to testing limitations. In Java, non-pharmaceutical interventions (NPIs) were implemented throughout 2020. However, as a v...

    Authors: Bimandra A. Djaafara, Charles Whittaker, Oliver J. Watson, Robert Verity, Nicholas F. Brazeau, Widyastuti, Dwi Oktavia, Verry Adrian, Ngabila Salama, Sangeeta Bhatia, Pierre Nouvellet, Ellie Sherrard-Smith, Thomas S. Churcher, Henry Surendra, Rosa N. Lina, Lenny L. Ekawati…

    Citation: BMC Medicine 2021 19:146

    Content type: Research article

    Published on:

  33. Trials of interventions to prevent or treat delirium in adults in an acute hospital setting report heterogeneous outcomes. Our objective was to develop international consensus among key stakeholders for a core...

    Authors: Louise Rose, Lisa Burry, Meera Agar, Bronagh Blackwood, Noll L. Campbell, Mike Clarke, John W. Devlin, Jacques Lee, John C. Marshall, Dale M. Needham, Najma Siddiqi and Valerie Page

    Citation: BMC Medicine 2021 19:143

    Content type: Research article

    Published on:

  34. Sedentary behaviour is potentially a modifiable risk factor for depression and anxiety disorders, but findings have been inconsistent. To assess the associations of sedentary behaviour with depression and anxi...

    Authors: A. A. Kandola, B. del Pozo Cruz, D. P. J. Osborn, B. Stubbs, K. W. Choi and J. F. Hayes

    Citation: BMC Medicine 2021 19:133

    Content type: Research article

    Published on:

  35. The risk of stroke in individuals with very low low-density lipoprotein cholesterol (LDL-C) concentrations remains high. We sought to prioritize predictive risk factors for stroke in Chinese participants with ...

    Authors: Zhijun Wu, Zhe Huang, Alice H. Lichtenstein, Yesong Liu, Shuohua Chen, Yao Jin, Muzi Na, Le Bao, Shouling Wu and Xiang Gao

    Citation: BMC Medicine 2021 19:142

    Content type: Research article

    Published on:

  36. Zero-events studies frequently occur in systematic reviews of adverse events, which consist of an important source of evidence. We aimed to examine how evidence of zero-events studies was utilized in the meta-...

    Authors: Chang Xu, Xiaoqin Zhou, Liliane Zorzela, Ke Ju, Luis Furuya-Kanamori, Lifeng Lin, Cuncun Lu, Omran A. H. Musa and Sunita Vohra

    Citation: BMC Medicine 2021 19:141

    Content type: Research article

    Published on:

  37. Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cellular therapy by harvesting infiltrated lymphocytes from tumors, culturing and amplifying them in vitro and then infusing back to treat pati...

    Authors: Shuhang Wang, Jingwei Sun, Kun Chen, Peiwen Ma, Qi Lei, Shujun Xing, Zhongzheng Cao, Shujun Sun, Zicheng Yu, Yarong Liu and Ning Li

    Citation: BMC Medicine 2021 19:140

    Content type: Review

    Published on:

  38. Artemisinin and artemisinin-based combination therapy (ACT) partner drug resistance in Plasmodium falciparum have spread across the Greater Mekong Subregion compromising antimalarial treatment. The current 3-day ...

    Authors: Makoto Saito, Verena I. Carrara, Mary Ellen Gilder, Aung Myat Min, Nay Win Tun, Mupawjay Pimanpanarak, Jacher Viladpai-nguen, Moo Kho Paw, Warat Haohankhunnatham, Kamonchanok Konghahong, Aung Pyae Phyo, Cindy Chu, Claudia Turner, Sue J. Lee, Jureeporn Duanguppama, Mallika Imwong…

    Citation: BMC Medicine 2021 19:132

    Content type: Research article

    Published on:

  39. Acute ischemic stroke (AIS) is a serious cause of mortality and disability. AIS is a serious cause of mortality and disability. Early diagnosis of atherosclerosis, which is the major cause of AIS, allows thera...

    Authors: Takaki Hiwasa, Hao Wang, Ken-ichiro Goto, Seiichiro Mine, Toshio Machida, Eiichi Kobayashi, Yoichi Yoshida, Akihiko Adachi, Tomoo Matsutani, Mizuki Sata, Kazumasa Yamagishi, Hiroyasu Iso, Norie Sawada, Shoichiro Tsugane, Mitoshi Kunimatsu, Ikuo Kamitsukasa…

    Citation: BMC Medicine 2021 19:131

    Content type: Research article

    Published on:

  40. Pertussis vaccines containing three or five pertussis antigens are recommended in pregnancy in many countries, but no studies have compared the effect on infants’ antigen-specific immunoglobulin G (IgG) concen...

    Authors: Christine Elizabeth Jones, Anna Calvert, Jo Southern, Mary Matheson, Nick Andrews, Asma Khalil, Hannah Cuthbertson, Bassam Hallis, Anna England, Paul T. Heath and Elizabeth Miller

    Citation: BMC Medicine 2021 19:138

    Content type: Research article

    Published on:

  41. The introduction of SARS-CoV-2, the virus that causes COVID-19 infection, in the UK in early 2020, resulted in the introduction of several control policies to reduce disease spread. As part of these restrictio...

    Authors: Emma Southall, Alex Holmes, Edward M. Hill, Benjamin D. Atkins, Trystan Leng, Robin N. Thompson, Louise Dyson, Matt J. Keeling and Michael J. Tildesley

    Citation: BMC Medicine 2021 19:137

    Content type: Research article

    Published on:

  42. Diagnosing bacterial meningitis is essential to optimise the type and duration of antimicrobial therapy to limit mortality and sequelae. In sub-Saharan Africa, many public hospitals lack laboratory capacity, r...

    Authors: Christina W. Obiero, Neema Mturi, Salim Mwarumba, Moses Ngari, Charles R. Newton, Michaël Boele van Hensbroek and James A. Berkley

    Citation: BMC Medicine 2021 19:122

    Content type: Research article

    Published on:

  43. Physical activity is associated with a reduced risk of type 2 diabetes and cardiovascular disease but limited evidence exists for the sustained promotion of increased physical activity within diabetes preventi...

    Authors: Kamlesh Khunti, Simon Griffin, Alan Brennan, Helen Dallosso, Melanie J. Davies, Helen C. Eborall, Charlotte L. Edwardson, Laura J. Gray, Wendy Hardeman, Laura Heathcote, Joe Henson, Daniel Pollard, Stephen J. Sharp, Stephen Sutton, Jacqui Troughton and Tom Yates

    Citation: BMC Medicine 2021 19:130

    Content type: Research article

    Published on:

  44. The impact of maternal obesity extends beyond birth, being independently associated with an increased risk of child obesity. Current evidence demonstrates that women provided with a dietary intervention during...

    Authors: Jennie Louise, Amanda J. Poprzeczny, Andrea R. Deussen, Christina Vinter, Mette Tanvig, Dorte Moller Jensen, Annick Bogaerts, Roland Devlieger, Fionnuala M. McAuliffe, Kristina M. Renault, Emma Carlsen, Nina Geiker, Lucilla Poston, Annette Briley, Shakila Thangaratinam and Jodie M. Dodd

    Citation: BMC Medicine 2021 19:128

    Content type: Research article

    Published on: