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  1. Premenstrual disorders, including premenstrual syndrome and premenstrual dysphoric disorder, are suggested to be correlated with suicidal behavior and accidents in cross-sectional and retrospective studies. Ho...

    Authors: Qian Yang, Arvid Sjölander, Yuchen Li, Alexander Viktorin, Elizabeth R. Bertone-Johnson, Weimin Ye, Fang Fang, Unnur A. Valdimarsdóttir and Donghao Lu

    Citation: BMC Medicine 2021 19:119

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:135

  2. Post-term gestation beyond 41+6 completed weeks of gestation is known to be associated with a sharp increase in the risk of stillbirth and perinatal mortality. However, the risk of common adverse outcomes related...

    Authors: Anthea C. Lindquist, Roxanne M. Hastie, Richard J. Hiscock, Natasha L. Pritchard, Susan P. Walker and Stephen Tong

    Citation: BMC Medicine 2021 19:126

    Content type: Research article

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  3. Soil-transmitted helminth (STH) infections are highly prevalent in resource-limited countries. We assessed the effect of a combination intervention aiming to enhance handwashing with soap on STH reinfection fo...

    Authors: Kenneth Makata, Jeroen Ensink, Philip Ayieko, Christian Hansen, Simon Sichalwe, Julius Mngara, Onike Mcharo, Humphrey Mazigo, Jeremiah Seni, Robert Dreibelbis, Sarah Rockowitz, Elialilia Okello, Heiner Grosskurth, Safari Kinung’hi and Saidi Kapiga

    Citation: BMC Medicine 2021 19:125

    Content type: Research article

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  4. Long-term effects of COVID-19, also called Long COVID, affect more than 10% of patients. The most severe cases (i.e. those requiring hospitalization) present a higher frequency of sequelae, but detailed inform...

    Authors: Álvaro Romero-Duarte, Mario Rivera-Izquierdo, Inmaculada Guerrero-Fernández de Alba, Marina Pérez-Contreras, Nicolás Francisco Fernández-Martínez, Rafael Ruiz-Montero, Álvaro Serrano-Ortiz, Rocío Ortiz González-Serna, Inmaculada Salcedo-Leal, Eladio Jiménez-Mejías and Antonio Cárdenas-Cruz

    Citation: BMC Medicine 2021 19:129

    Content type: Research article

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  5. Children living in sub-Saharan Africa have a high burden of rickets and infectious diseases, conditions that are linked to vitamin D deficiency. However, data on the vitamin D status of young African children ...

    Authors: Reagan M. Mogire, Alireza Morovat, John Muthii Muriuki, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Manjinder S. Sandhu, Andrew M. Prentice…

    Citation: BMC Medicine 2021 19:115

    Content type: Research article

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  6. Sex differences in major cardiovascular risk factors for incident (fatal or non-fatal) all-cause dementia were assessed in the UK Biobank. The effects of these risk factors on all-cause dementia were explored ...

    Authors: Jessica Gong, Katie Harris, Sanne A. E. Peters and Mark Woodward

    Citation: BMC Medicine 2021 19:110

    Content type: Research article

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  7. Non-sputum methods are urgently needed to improve tuberculosis diagnosis and treatment monitoring in children. This study evaluated the ability of a serum assay quantifying a species-specific peptide of the Mycob...

    Authors: Liyan Mao, Sylvia M. LaCourse, Soyeon Kim, Chang Liu, Bo Ning, Duran Bao, Jia Fan, Christopher J. Lyon, Ziyong Sun, Sharon Nachman, Charles D. Mitchell and Tony Y. Hu

    Citation: BMC Medicine 2021 19:113

    Content type: Technical advance

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  8. The COVID-19 pandemic and ensuing national lockdowns have dramatically changed the healthcare landscape. The pandemic’s impact on people with chronic obstructive pulmonary disease (COPD) remains poorly underst...

    Authors: Mohammad A. Alsallakh, Shanya Sivakumaran, Sharon Kennedy, Eleftheria Vasileiou, Ronan A. Lyons, Chris Robertson, Aziz Sheikh and Gwyneth A. Davies

    Citation: BMC Medicine 2021 19:124

    Content type: Research article

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  9. For 20 years, the Global Outbreak Response and Alert Network (GOARN) has been a leader in the coordination of international outbreak response. On the premise that no single institution can provide all capaciti...

    Authors: Renee Christensen, Dale Fisher, Sharon Salmon, Patrick Drury and Paul Effler

    Citation: BMC Medicine 2021 19:123

    Content type: Correspondence

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  10. Improved access to effective antiretroviral therapy has meant that people living with HIV (PLHIV) are surviving to older ages. However, PLHIV may be ageing differently to HIV-negative individuals, with dissimi...

    Authors: Katherine Davis, Pablo Perez-Guzman, Annika Hoyer, Ralph Brinks, Edward Gregg, Keri N. Althoff, Amy C. Justice, Peter Reiss, Simon Gregson and Mikaela Smit

    Citation: BMC Medicine 2021 19:105

    Content type: Research article

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    The Correction to this article has been published in BMC Medicine 2021 19:228

    The Commentary to this article has been published in BMC Medicine 2021 19:112

  11. In the first wave of the COVID-19 pandemic, the hypothesis that angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) increased the risk and/or severity of the disease was w...

    Authors: Francisco J. de Abajo, Antonio Rodríguez-Miguel, Sara Rodríguez-Martín, Victoria Lerma and Alberto García-Lledó

    Citation: BMC Medicine 2021 19:118

    Content type: Research article

    Published on:

    The Commentary to this article has been published in BMC Medicine 2021 19:136

  12. Hypertension is the largest single contributor to the global burden of disease, affecting an estimated 1.39 billion people worldwide. Clinical practice guidelines (CPGs) can aid in the effective management of ...

    Authors: Richu Philip, Thomas Beaney, Nick Appelbaum, Carmen Rodriguez Gonzalvez, Charlotte Koldeweij, Amelia Kataria Golestaneh, Neil Poulter and Jonathan M. Clarke

    Citation: BMC Medicine 2021 19:117

    Content type: Research article

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  13. Sleep apnoea, a common sleep-disordered breathing condition, is characterised by upper airway collapse during sleep resulting in transient hypoxia, hypoperfusion of the optic nerve, and spike in intracranial p...

    Authors: Xikun Han, Samantha Sze-Yee Lee, Nathan Ingold, Nigel McArdle, Anthony P. Khawaja, Stuart MacGregor and David A. Mackey

    Citation: BMC Medicine 2021 19:104

    Content type: Research article

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  14. COVID-19 outbreaks have occurred in homeless shelters across the US, highlighting an urgent need to identify the most effective infection control strategy to prevent future outbreaks.

    Authors: Lloyd A. C. Chapman, Margot Kushel, Sarah N. Cox, Ashley Scarborough, Caroline Cawley, Trang Q. Nguyen, Isabel Rodriguez-Barraquer, Bryan Greenhouse, Elizabeth Imbert and Nathan C. Lo

    Citation: BMC Medicine 2021 19:116

    Content type: Research article

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  15. Cigarette smoking is a well-known risk factor for cardiovascular disease (CVD), but whether smokeless tobacco such as snuff is associated with the risk of CVD is still unclear. We investigated the association ...

    Authors: Olga E. Titova, John A. Baron, Karl Michaëlsson and Susanna C. Larsson

    Citation: BMC Medicine 2021 19:111

    Content type: Research article

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  16. Depression is commonly perceived as a single underlying disease with a number of potential treatment options. However, patients with major depression differ dramatically in their symptom presentation and comor...

    Authors: C. O’Driscoll, J. E. J. Buckman, E. I. Fried, R. Saunders, Z. D. Cohen, G. Ambler, R. J. DeRubeis, S. Gilbody, S. D. Hollon, T. Kendrick, D. Kessler, G. Lewis, E. Watkins, N. Wiles and S. Pilling

    Citation: BMC Medicine 2021 19:109

    Content type: Research article

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  17. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Haoxiang Cheng, Anshuman Sewda, Carla Marquez-Luna, Sierra R. White, Bridget M. Whitney, Jessica Williams-Nguyen, Robin M. Nance, Won Jun Lee, Mari M. Kitahata, Michael S. Saag, Amanda Willig, Joseph J. Eron, W. Christopher Mathews, Peter W. Hunt, Richard D. Moore, Allison Webel…

    Citation: BMC Medicine 2021 19:114

    Content type: Correction

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    The original article was published in BMC Medicine 2020 18:288

  18. Cerebral small vessel disease (CSVD) is a common neurological disease present in the ageing population that is associated with an increased risk of dementia and stroke. Damage to white matter tracts compromise...

    Authors: Maximilian Schulz, Caroline Malherbe, Bastian Cheng, Götz Thomalla and Eckhard Schlemm

    Citation: BMC Medicine 2021 19:103

    Content type: Research article

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  19. During the millennium development goals period, reduction in under-five mortality (U5M) and increases in child health intervention coverage were characterised by sub-national disparities and inequities across ...

    Authors: Peter M. Macharia, Noel K. Joseph, Robert W. Snow, Benn Sartorius and Emelda A. Okiro

    Citation: BMC Medicine 2021 19:102

    Content type: Research article

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  20. The mechanisms underlying the obesity-cancer relationship are incompletely understood. This study aimed to characterise metabolic signatures of greater body size and to investigate their association with two o...

    Authors: Nathalie Kliemann, Vivian Viallon, Neil Murphy, Rebecca J. Beeken, Joseph A. Rothwell, Sabina Rinaldi, Nada Assi, Eline H. van Roekel, Julie A. Schmidt, Kristin Benjaminsen Borch, Claudia Agnoli, Ann H. Rosendahl, Hanna Sartor, José María Huerta, Anne Tjønneland, Jytte Halkjær…

    Citation: BMC Medicine 2021 19:101

    Content type: Research article

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  21. Accumulating evidences have suggested that high body fat percentage (BF%) often occurs in parallel with cardiovascular diseases (CVDs), implying a common etiology between them. However, the shared genetic etio...

    Authors: Zhenhuang Zhuang, Minhao Yao, Jason Y. Y. Wong, Zhonghua Liu and Tao Huang

    Citation: BMC Medicine 2021 19:100

    Content type: Research article

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  22. Lithium is the most effective treatment in bipolar disorder. Its use is limited by concerns about risk of chronic kidney disease (CKD). We aimed to develop a model to predict risk of CKD following lithium trea...

    Authors: Joseph F. Hayes, David P. J. Osborn, Emma Francis, Gareth Ambler, Laurie A. Tomlinson, Magnus Boman, Ian C. K. Wong, John R. Geddes, Christina Dalman and Glyn Lewis

    Citation: BMC Medicine 2021 19:99

    Content type: Research article

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  23. Routine asymptomatic testing using RT-PCR of people who interact with vulnerable populations, such as medical staff in hospitals or care workers in care homes, has been employed to help prevent outbreaks among...

    Authors: Joel Hellewell, Timothy W. Russell, Rupert Beale, Gavin Kelly, Catherine Houlihan, Eleni Nastouli and Adam J. Kucharski

    Citation: BMC Medicine 2021 19:106

    Content type: Research article

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  24. Malaria and hypertensive disorders of pregnancy (HDoP) affect millions of pregnancies worldwide, particularly those of young, first-time mothers. Small case-control studies suggest a positive association betwe...

    Authors: Whitney E. Harrington, Kerryn A. Moore, Aung Myat Min, Mary Ellen Gilder, Nay Win Tun, Moo Kho Paw, Jacher Wiladphaingern, Stephane Proux, Kesinee Chotivanich, Marcus J. Rijken, Nicholas J. White, François Nosten and Rose McGready

    Citation: BMC Medicine 2021 19:98

    Content type: Research article

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  25. Whether a modestly elevated homocysteine level is causally associated with an increased risk of cardiovascular disease remains unestablished. We conducted a Mendelian randomization study to assess the associat...

    Authors: Shuai Yuan, Amy M. Mason, Paul Carter, Stephen Burgess and Susanna C. Larsson

    Citation: BMC Medicine 2021 19:97

    Content type: Research article

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  26. Traditionally, studies investigating diet and health associations have focused on single nutrients. However, key nutrients co-exist in many common foods, and studies focusing solely on individual nutrients may...

    Authors: Min Gao, Susan A. Jebb, Paul Aveyard, Gina L. Ambrosini, Aurora Perez-Cornago, Jennifer Carter, Xinying Sun and Carmen Piernas

    Citation: BMC Medicine 2021 19:83

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:108

  27. Most studies on secular trends in body mass index (BMI) are cross-sectional and the few longitudinal studies have typically only investigated changes over time in mean BMI trajectories. We aimed to describe ho...

    Authors: T. Norris, M. Hamer, R. Hardy, L. Li, K. K. Ong, G. B. Ploubidis, R. Viner and W. Johnson

    Citation: BMC Medicine 2021 19:96

    Content type: Research article

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  28. Large-scale rural-to-urban migration has changed the epidemiology of tuberculosis (TB) in large Chinese cities. We estimated the contribution of TB importation, reactivation of latent infection, and local tran...

    Authors: Chongguang Yang, Jian Kang, Liping Lu, Xiaoqin Guo, Xin Shen, Ted Cohen and Nicolas A. Menzies

    Citation: BMC Medicine 2021 19:95

    Content type: Research article

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  29. The associations between England’s incentivised primary care-based diabetes prevention activities and hard clinical endpoints remain unclear. We aimed to examine the associations between attainment of primary ...

    Authors: Ailsa J. McKay, Laura H. Gunn, Thirunavukkarasu Sathish, Eszter Vamos, Manjula Nugawela, Azeem Majeed, German Molina and Sobha Sivaprasad

    Citation: BMC Medicine 2021 19:93

    Content type: Research article

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  30. Increasing evidence highlights healthy dietary patterns and links daily cooking oil intake with chronic diseases including cardiovascular disease (CVD) and diabetes. However, food-based evidence supporting the...

    Authors: Yu Zhang, Pan Zhuang, Fei Wu, Wei He, Lei Mao, Wei Jia, Yiju Zhang, Xiaoqian Chen and Jingjing Jiao

    Citation: BMC Medicine 2021 19:92

    Content type: Research article

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  31. Balancing the control of SARS-CoV-2 transmission with the resumption of travel is a global priority. Current recommendations include mitigation measures before, during, and after travel. Pre- and post-travel s...

    Authors: Michael A. Johansson, Hannah Wolford, Prabasaj Paul, Pamela S. Diaz, Tai-Ho Chen, Clive M. Brown, Martin S. Cetron and Francisco Alvarado-Ramy

    Citation: BMC Medicine 2021 19:94

    Content type: Research article

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  32. More than one third of Norwegian women and men between 20 and 40 years of age have elevated cholesterol concentration. Parental metabolic health around conception or during pregnancy may affect the offspring’s...

    Authors: Linn K. L. Øyri, Martin P. Bogsrud, Jacob J. Christensen, Stine M. Ulven, Anne Lise Brantsæter, Kjetil Retterstøl, Hilde K. Brekke, Trond M. Michelsen, Tore Henriksen, Jeanine E. Roeters van Lennep, Per Magnus, Marit B. Veierød and Kirsten B. Holven

    Citation: BMC Medicine 2021 19:91

    Content type: Research article

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  33. COVID-19 spread may have a dramatic impact in countries with vulnerable economies and limited availability of, and access to, healthcare resources and infrastructures. However, in sub-Saharan Africa, a low pre...

    Authors: Filippo Trentini, Giorgio Guzzetta, Margherita Galli, Agnese Zardini, Fabio Manenti, Giovanni Putoto, Valentina Marziano, Worku Nigussa Gamshie, Ademe Tsegaye, Alessandro Greblo, Alessia Melegaro, Marco Ajelli, Stefano Merler and Piero Poletti

    Citation: BMC Medicine 2021 19:89

    Content type: Research article

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  34. An accurate and comprehensive assessment of harms is a fundamental part of an accurate weighing of benefits and harms of an intervention when making treatment decisions; however, harms are known to be underrep...

    Authors: Asger S. Paludan-Müller, Perrine Créquit and Isabelle Boutron

    Citation: BMC Medicine 2021 19:88

    Content type: Research article

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  35. The use of prenatal dexamethasone remains controversial. Our recent studies found that prenatal dexamethasone exposure can induce maternal intrahepatic cholestasis and have a lasting adverse influence on bile ...

    Authors: Wen Huang, Jin Zhou, Juanjuan Guo, Wen Hu, Guanghui Chen, Bin Li, Yajie Wen, Yimin Jiang, Kaili Fu, Huichang Bi, Yuanzhen Zhang and Hui Wang

    Citation: BMC Medicine 2021 19:87

    Content type: Research article

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  36. Machine learning (ML) is increasingly used in research for subtype definition and risk prediction, particularly in cardiovascular diseases. No existing ML models are routinely used for cardiovascular disease m...

    Authors: Amitava Banerjee, Suliang Chen, Ghazaleh Fatemifar, Mohamad Zeina, R. Thomas Lumbers, Johanna Mielke, Simrat Gill, Dipak Kotecha, Daniel F. Freitag, Spiros Denaxas and Harry Hemingway

    Citation: BMC Medicine 2021 19:85

    Content type: Research article

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  37. Gambiense human African trypanosomiasis (gHAT) has been brought under control recently with village-based active screening playing a major role in case reduction. In the approach to elimination, we investigate ho...

    Authors: Christopher N. Davis, Kat S. Rock, Marina Antillón, Erick Mwamba Miaka and Matt J. Keeling

    Citation: BMC Medicine 2021 19:86

    Content type: Research article

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  38. Trans fatty acids (TFAs) have been hypothesised to influence breast cancer risk. However, relatively few prospective studies have examined this relationship, and well-powered analyses according to hormone recepto...

    Authors: Michèle Matta, Inge Huybrechts, Carine Biessy, Corinne Casagrande, Sahar Yammine, Agnès Fournier, Karina Standahl Olsen, Marco Lukic, Inger Torhild Gram, Eva Ardanaz, Maria-José Sánchez, Laure Dossus, Renée T. Fortner, Bernard Srour, Franziska Jannasch, Matthias B. Schulze…

    Citation: BMC Medicine 2021 19:81

    Content type: Research article

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  39. Targeted therapy and immunotherapy put forward higher demands for accurate lung cancer classification, as well as benign versus malignant disease discrimination. Digital whole slide images (WSIs) witnessed the...

    Authors: Huan Yang, Lili Chen, Zhiqiang Cheng, Minglei Yang, Jianbo Wang, Chenghao Lin, Yuefeng Wang, Leilei Huang, Yangshan Chen, Sui Peng, Zunfu Ke and Weizhong Li

    Citation: BMC Medicine 2021 19:80

    Content type: Research article

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  40. Whether earlier onset of puberty is associated with higher cardiovascular risk in early adulthood is not well understood. Our objective was to examine the association between puberty timing and markers of card...

    Authors: Gillian M. Maher, Lisa Ryan, Fergus P. McCarthy, Alun Hughes, Chloe Park, Abigail Fraser, Laura D. Howe, Patricia M. Kearney and Linda M. O’Keeffe

    Citation: BMC Medicine 2021 19:78

    Content type: Research article

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  41. Accurate and robust pathological image analysis for colorectal cancer (CRC) diagnosis is time-consuming and knowledge-intensive, but is essential for CRC patients’ treatment. The current heavy workload of path...

    Authors: K. S. Wang, G. Yu, C. Xu, X. H. Meng, J. Zhou, C. Zheng, Z. Deng, L. Shang, R. Liu, S. Su, X. Zhou, Q. Li, J. Li, J. Wang, K. Ma, J. Qi…

    Citation: BMC Medicine 2021 19:76

    Content type: Research article

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  42. Severe mental illness (SMI), comprising schizophrenia, bipolar disorder and major depression, is associated with higher myocardial infarction (MI) mortality but lower coronary revascularisation rates. Previous...

    Authors: Kelly Fleetwood, Sarah H. Wild, Daniel J. Smith, Stewart W. Mercer, Kirsty Licence, Cathie L. M. Sudlow and Caroline A. Jackson

    Citation: BMC Medicine 2021 19:67

    Content type: Research article

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