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  1. Since 2013, a biennial rotavirus pattern has emerged in the Netherlands with alternating high and low endemic years and a nearly 50% reduction in rotavirus hospitalization rates overall, while infant rotavirus...

    Authors: P. Bruijning-Verhagen, J. A. P. van Dongen, J. D. M. Verberk, R. Pijnacker, R. D. van Gaalen, D. Klinkenberg, H. E. de Melker and M.-J. J. Mangen
    Citation: BMC Medicine 2018 16:168
  2. The science of complex systems has been proposed as a way of understanding health services and the demand for them, but there is little quantitative evidence to support this. We analysed patterns of healthcare...

    Authors: Christopher Burton, Alison Elliott, Amanda Cochran and Tom Love
    Citation: BMC Medicine 2018 16:138
  3. Brazil has high burdens of tuberculosis (TB) and HIV, as previously estimated for the 26 states and the Federal District, as well as high levels of inequality in social and health indicators. We improved the g...

    Authors: Jennifer M. Ross, Nathaniel J. Henry, Laura A. Dwyer-Lindgren, Andrea de Paula Lobo, Fatima Marinho de Souza, Molly H. Biehl, Sarah E. Ray, Robert C. Reiner Jr, Rebecca W. Stubbs, Kirsten E. Wiens, Lucas Earl, Michael J. Kutz, Natalia V. Bhattacharjee, Hmwe H. Kyu, Mohsen Naghavi and Simon I. Hay
    Citation: BMC Medicine 2018 16:144
  4. There is increasing interest in estimating the broader benefits of public health interventions beyond those captured in traditional cost-utility analyses. Cost-benefit analysis (CBA) in principle offers a way ...

    Authors: Minah Park, Mark Jit and Joseph T. Wu
    Citation: BMC Medicine 2018 16:139
  5. The ever-increasing number of reasons forcing people to flee from their homes to new, safer places either within their countries of origin, into neighbouring countries or across continental, conversant and cul...

    Authors: Mina Fazel
    Citation: BMC Medicine 2018 16:164

    The original article was published in BMC Medicine 2018 16:157

  6. High-income countries like Australia play a vital role in resettling refugees from around the world, half of whom are children and adolescents. Informed by an ecological framework, this study examined the post...

    Authors: Winnie Lau, Derrick Silove, Ben Edwards, David Forbes, Richard Bryant, Alexander McFarlane, Dusan Hadzi-Pavlovic, Zachary Steel, Angela Nickerson, Miranda Van Hooff, Kim Felmingham, Sean Cowlishaw, Nathan Alkemade, Dzenana Kartal and Meaghan O’Donnell
    Citation: BMC Medicine 2018 16:157

    The Commentary to this article has been published in BMC Medicine 2018 16:164

  7. We have previously conducted computer-based tournaments to compare the yield of alternative approaches to deploying mobile HIV testing services in settings where the prevalence of undetected infection may be c...

    Authors: Gregg S. Gonsalves, J. Tyler Copple, Tyler Johnson, A. David Paltiel and Joshua L. Warren
    Citation: BMC Medicine 2018 16:155
  8. The association between Institute of Medicine (IOM) guidelines and pregnancy outcomes across ethnicities is uncertain. We evaluated the associations of gestational weight gain (GWG) outside 2009 IOM guidelines...

    Authors: Rebecca F. Goldstein, Sally K. Abell, Sanjeeva Ranasinha, Marie L. Misso, Jacqueline A. Boyle, Cheryce L. Harrison, Mary Helen Black, Nan Li, Gang Hu, Francesco Corrado, Hanne Hegaard, Young Ju Kim, Margaretha Haugen, Won O. Song, Min Hyoung Kim, Annick Bogaerts…
    Citation: BMC Medicine 2018 16:153
  9. Mathematical models of transmission dynamics are routinely fitted to epidemiological time series, which must inevitably be aggregated at some spatial scale. Weekly case reports of chikungunya have been made av...

    Authors: Sean M. Moore, Quirine A. ten Bosch, Amir S. Siraj, K. James Soda, Guido España, Alfonso Campo, Sara Gómez, Daniela Salas, Benoit Raybaud, Edward Wenger, Philip Welkhoff and T. Alex Perkins
    Citation: BMC Medicine 2018 16:152
  10. Introduced in 2004, the United Kingdom’s (UK) Quality and Outcomes Framework (QOF) is the world’s largest primary-care pay-for-performance programme. Given some evidence of the benefits and the substantial cos...

    Authors: Ankur Pandya, Tim Doran, Jinyi Zhu, Simon Walker, Emily Arntson and Andrew M. Ryan
    Citation: BMC Medicine 2018 16:135
  11. The UK, like a number of other countries, has a refugee resettlement programme. External factors, such as higher prevalence of infectious diseases in the country of origin and circumstances of travel, are like...

    Authors: Alison F. Crawshaw, Manish Pareek, John Were, Steffen Schillinger, Olga Gorbacheva, Kolitha P. Wickramage, Sema Mandal, Valerie Delpech, Noel Gill, Hilary Kirkbride and Dominik Zenner
    Citation: BMC Medicine 2018 16:143
  12. Personalized, precision, P4, or stratified medicine is understood as a medical approach in which patients are stratified based on their disease subtype, risk, prognosis, or treatment response using specialized...

    Authors: Holger Fröhlich, Rudi Balling, Niko Beerenwinkel, Oliver Kohlbacher, Santosh Kumar, Thomas Lengauer, Marloes H. Maathuis, Yves Moreau, Susan A. Murphy, Teresa M. Przytycka, Michael Rebhan, Hannes Röst, Andreas Schuppert, Matthias Schwab, Rainer Spang, Daniel Stekhoven…
    Citation: BMC Medicine 2018 16:150
  13. The original article [1] contains errors in Table 1 affecting some of the presented oligonucleotide sequences and readthrough values in Table 1.

    Authors: I. Sermet-Gaudelus, M. Renouil, A. Fajac, L. Bidou, B. Parbaille, S. Pierrot, N. Davy, E. Bismuth, P. Reinert, G. Lenoir, J. F. Lesure, J. P. Rousset and A. Edelman
    Citation: BMC Medicine 2018 16:159

    The original article was published in BMC Medicine 2007 5:5

  14. Non-alcoholic fatty liver disease (NAFLD) has emerged as a common cause of liver-related morbidity and mortality. Tackling this condition at a societal level will require a clear understanding of the burden of...

    Authors: Arun J. Sanyal
    Citation: BMC Medicine 2018 16:148

    The original article was published in BMC Medicine 2018 16:130

  15. The question of whether depression is a causal factor in somatic diseases remains unanswered despite decades of research. In an extensive umbrella review of systematic reviews and meta-analyses, Machado et al. (B...

    Authors: Annelieke M. Roest and Peter de Jonge
    Citation: BMC Medicine 2018 16:147

    The original article was published in BMC Medicine 2018 16:112

  16. Antibiotic-resistant bacteria (ARB) are selected by the use of antibiotics. The rational design of interventions to reduce levels of antibiotic resistance requires a greater understanding of how and where ARB ...

    Authors: Gwenan M. Knight, Céire Costelloe, Sarah R. Deeny, Luke S. P. Moore, Susan Hopkins, Alan P. Johnson, Julie V. Robotham and Alison H. Holmes
    Citation: BMC Medicine 2018 16:137
  17. Studies have shown that alcohol intake trajectories differ in their associations with biomarkers of cardiovascular functioning, but it remains unclear if they also differ in their relationship to actual corona...

    Authors: Dara O’Neill, Annie Britton, Mary K. Hannah, Marcel Goldberg, Diana Kuh, Kay Tee Khaw and Steven Bell
    Citation: BMC Medicine 2018 16:124
  18. The prognosis of pancreatic cancer (PaC) strongly varies across different stages and age groups, which has unfortunately not been well recorded in the literature. This international population-based study aime...

    Authors: Lei Huang, Lina Jansen, Yesilda Balavarca, Masoud Babaei, Lydia van der Geest, Valery Lemmens, Liesbet Van Eycken, Harlinde De Schutter, Tom B. Johannesen, Maja Primic-Žakelj, Vesna Zadnik, Marc G. Besselink, Petra Schrotz-King and Hermann Brenner
    Citation: BMC Medicine 2018 16:125
  19. Although routine vaccination of females before sexual debut against human papillomavirus (HPV) has been found to be cost-effective around the world, its cost-benefit has rarely been examined. We evaluate both ...

    Authors: Horace C. W. Choi, Mark Jit, Gabriel M. Leung, Kwok-Leung Tsui and Joseph T. Wu
    Citation: BMC Medicine 2018 16:127
  20. Enterobacteriaceae are a common cause of hospital infections. Carbapenems are a clinically effective treatment of such infections. However, resistance is on the rise. In particular, carbapenemase-producing car...

    Authors: Gwenan M. Knight, Eleonora Dyakova, Siddharth Mookerjee, Frances Davies, Eimear T. Brannigan, Jonathan A. Otter and Alison H. Holmes
    Citation: BMC Medicine 2018 16:141
  21. In an era when obesity prevalence is high throughout much of the world, there is a correspondingly pervasive and strong culture of weight stigma. For example, representative studies show that some forms of wei...

    Authors: A. Janet Tomiyama, Deborah Carr, Ellen M. Granberg, Brenda Major, Eric Robinson, Angelina R. Sutin and Alexandra Brewis
    Citation: BMC Medicine 2018 16:123
  22. Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing causality has proven challenging. Since vit...

    Authors: Yazhou He, Maria Timofeeva, Susan M. Farrington, Peter Vaughan-Shaw, Victoria Svinti, Marion Walker, Lina Zgaga, Xiangrui Meng, Xue Li, Athina Spiliopoulou, Xia Jiang, Elina Hyppönen, Peter Kraft, Douglas P. Kiel, Caroline Hayward, Archie Campbell…
    Citation: BMC Medicine 2018 16:142
  23. Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide. It affects an estimated 20% of the general population, based on cohort studies of varying size and heterogeneous s...

    Authors: Myriam Alexander, A. Katrina Loomis, Jolyon Fairburn-Beech, Johan van der Lei, Talita Duarte-Salles, Daniel Prieto-Alhambra, David Ansell, Alessandro Pasqua, Francesco Lapi, Peter Rijnbeek, Mees Mosseveld, Paul Avillach, Peter Egger, Stuart Kendrick, Dawn M. Waterworth, Naveed Sattar…
    Citation: BMC Medicine 2018 16:130

    The Commentary to this article has been published in BMC Medicine 2018 16:148

  24. The authors have retracted this article, The impact of repeated vaccination on influenza vaccine effectiveness: a systematic review and meta-analysis.

    Authors: Lauren C. Ramsay, Sarah A. Buchan, Robert G. Stirling, Benjamin J. Cowling, Shou Feng, Jeffrey C. Kwong and Bryna F. Warshawsky
    Citation: BMC Medicine 2018 16:133

    The original article was published in BMC Medicine 2017 15:159

  25. The original article [1] contains an error affecting the actigraphy time-stamps throughout the article, particularly in Table 1.

    Authors: D. Cruse, A. Thibaut, A. Demertzi, J. C. Nantes, M. A. Bruno, O. Gosseries, A. Vanhaudenhuyse, T. A. Bekinschtein, A. M. Owen and S. Laureys
    Citation: BMC Medicine 2018 16:134

    The original article was published in BMC Medicine 2013 11:18

  26. A recent concept is that obesity, assessed by body mass index (BMI), is not always a sign of poor health. Thus, in order to use obesity metrics in clinical decision making, it is important to clarify the relat...

    Authors: Geum Joon Cho, Hye Jin Yoo, Soon Young Hwang, Jun Choi, Kyu-Min Lee, Kyung Mook Choi, Sei Hyun Baik, Sung Won Han and Tak Kim
    Citation: BMC Medicine 2018 16:131
  27. Online dietary assessment tools can reduce administrative costs and facilitate repeated dietary assessment during follow-up in large-scale studies. However, information on bias due to measurement error of such...

    Authors: Petra A. Wark, Laura J. Hardie, Gary S. Frost, Nisreen A. Alwan, Michelle Carter, Paul Elliott, Heather E. Ford, Neil Hancock, Michelle A. Morris, Umme Z. Mulla, Essra A. Noorwali, K. Petropoulou, David Murphy, Gregory D. M. Potter, Elio Riboli, Darren C. Greenwood…
    Citation: BMC Medicine 2018 16:136
  28. In Canada, tuberculosis disproportionately affects foreign-born and First Nations populations. Within First Nations’ peoples, a high proportion of cases occur in association with outbreaks. Tuberculosis transm...

    Authors: Alexander Doroshenko, Caitlin S. Pepperell, Courtney Heffernan, Mary Lou Egedahl, Tatum D. Mortimer, Tracy M. Smith, Hailey E. Bussan, Gregory J. Tyrrell and Richard Long
    Citation: BMC Medicine 2018 16:128
  29. Antibiotic resistance is an urgent global problem, but reversibility is poorly understood. We examined the development and decay of bacterial resistance in community patients after antibiotic use.

    Authors: Mina Bakhit, Tammy Hoffmann, Anna Mae Scott, Elaine Beller, John Rathbone and Chris Del Mar
    Citation: BMC Medicine 2018 16:126
  30. Dengue, a vector-borne infectious disease caused by the dengue virus, has spread through tropical and subtropical regions of the world. All four serotypes of dengue viruses are endemic in the equatorial city s...

    Authors: Yirong Chen, Janet Hui Yi Ong, Jayanthi Rajarethinam, Grace Yap, Lee Ching Ng and Alex R. Cook
    Citation: BMC Medicine 2018 16:129
  31. Congregate settings may serve as institutional amplifiers of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and pathogen genetic data prospectively collec...

    Authors: Joshua L. Warren, Louis Grandjean, David A. J. Moore, Anna Lithgow, Jorge Coronel, Patricia Sheen, Jonathan L. Zelner, Jason R. Andrews and Ted Cohen
    Citation: BMC Medicine 2018 16:122
  32. Coeliac disease affects approximately 1% of the population and is increasingly diagnosed in the United Kingdom. A nationwide consultation in England has recommend that state-funded provisions for gluten-free (...

    Authors: Myles-Jay Linton, Tim Jones, Amanda Owen-Smith, Rupert A. Payne, Joanna Coast, Joel Glynn and William Hollingworth
    Citation: BMC Medicine 2018 16:119
  33. The results of liver transplantation are excellent, with survival rates of over 90 and 80% at 1 and 5 years, respectively. The success of liver transplantation has led to an increase in the indications for liv...

    Authors: Didier Samuel and Audrey Coilly
    Citation: BMC Medicine 2018 16:113
  34. Rates of emergency hospitalisations are increasing in many countries, leading to disruption in the quality of care and increases in cost. Therefore, identifying strategies to reduce emergency admission rates i...

    Authors: Niklas Bobrovitz, Carl Heneghan, Igho Onakpoya, Benjamin Fletcher, Dylan Collins, Alice Tompson, Joseph Lee, David Nunan, Rebecca Fisher, Brittney Scott, Jack O’Sullivan, Oliver Van Hecke, Brian D. Nicholson, Sarah Stevens, Nia Roberts and Kamal R. Mahtani
    Citation: BMC Medicine 2018 16:115

    The Commentary to this article has been published in BMC Medicine 2018 16:169

  35. Sub-Saharan Africa (SSA) continues to suffer high communicable disease burdens as its demographic transition (DT) proceeds. Although the consequent changes in population structures influence age-specific conta...

    Authors: John R. Williams, Piero Manfredi and Alessia Melegaro
    Citation: BMC Medicine 2018 16:118
  36. The presence of concomitant medical conditions in people with dementia is common. Dementia may be related to differential use of health, social and informal care.

    Authors: Holly Q. Bennett, Sam Norton, Frances Bunn, Louise Robinson, Greta Rait, Claire Goodman, Carol Brayne and Fiona E. Matthews
    Citation: BMC Medicine 2018 16:114
  37. Most evidence about what works in transitional care comes from small studies in single clinical specialties. We tested the hypothesis that exposures to nine recommended features of transitional healthcare were...

    Authors: A. Colver, H. McConachie, A. Le Couteur, G. Dovey-Pearce, K. D. Mann, J. E. McDonagh, M. S. Pearce, L. Vale, H. Merrick and J. R. Parr
    Citation: BMC Medicine 2018 16:111
  38. Depression is a prevalent and disabling mental disorder that frequently co-occurs with a wide range of chronic conditions. Evidence has suggested that depression could be associated with excess all-cause morta...

    Authors: Myrela O. Machado, Nicola Veronese, Marcos Sanches, Brendon Stubbs, Ai Koyanagi, Trevor Thompson, Ioanna Tzoulaki, Marco Solmi, Davy Vancampfort, Felipe B. Schuch, Michael Maes, Giovanni A. Fava, John P. A. Ioannidis and André F. Carvalho
    Citation: BMC Medicine 2018 16:112

    The Commentary to this article has been published in BMC Medicine 2018 16:147

  39. As complete reporting is essential to judge the validity and applicability of multivariable prediction models, a guideline for the Transparent Reporting of a multivariable prediction model for Individual Progn...

    Authors: Pauline Heus, Johanna A. A. G. Damen, Romin Pajouheshnia, Rob J. P. M. Scholten, Johannes B. Reitsma, Gary S. Collins, Douglas G. Altman, Karel G. M. Moons and Lotty Hooft
    Citation: BMC Medicine 2018 16:120
  40. Human papillomavirus (HPV) vaccination is safe and effective in preventing cervical cancer in females. As HPV infections can also induce cancers of the anus, penis and oral cavity, male vaccination is also adv...

    Authors: Thomas Harder, Ole Wichmann, Stefanie J. Klug, Marianne A. B. van der Sande and Miriam Wiese-Posselt
    Citation: BMC Medicine 2018 16:110
  41. The present study aims to evaluate the cost-effectiveness of the newly introduced varicella and herpes zoster (HZ) vaccination programmes in Italy. The appropriateness of the introduction of the varicella vacc...

    Authors: Alessia Melegaro, Valentina Marziano, Emanuele Del Fava, Piero Poletti, Marcello Tirani, Caterina Rizzo and Stefano Merler
    Citation: BMC Medicine 2018 16:117
  42. Intensification of metformin monotherapy with additional glucose-lowering drugs is often required in patients with type 2 diabetes (T2D). This study evaluated changes in HbA1c and weight, as well as treatment ...

    Authors: John Wilding, Thomas Godec, Kamlesh Khunti, Stuart Pocock, Robin Fox, Liam Smeeth, Per Clauson, Peter Fenici, Niklas Hammar and Jesús Medina
    Citation: BMC Medicine 2018 16:116
  43. The RTS,S/AS01 vaccine for Plasmodium falciparum malaria demonstrated moderate efficacy in 5–17-month-old children in phase 3 trials, and from 2018, the vaccine will be evaluated through a large-scale pilot imple...

    Authors: Alexandra B. Hogan, Peter Winskill, Robert Verity, Jamie T. Griffin and Azra C. Ghani
    Citation: BMC Medicine 2018 16:109
  44. Caregivers may promote the uptake of science into patient care and the practice of evidence-informed medicine. The purpose of this study was to determine whether caregiver-mediated (non-clinical caregiver-deli...

    Authors: Kirsten M. Fiest, Christiane Job McIntosh, Danielle Demiantschuk, Jeanna Parsons Leigh and Henry T. Stelfox
    Citation: BMC Medicine 2018 16:105
  45. For patients starting treatment for depression, current guidelines recommend titrating the antidepressant dosage to the maximum of the licenced range if tolerated. When patients do not achieve remission within...

    Authors: Tadashi Kato, Toshi A. Furukawa, Akio Mantani, Ken’ichi Kurata, Hajime Kubouchi, Susumu Hirota, Hirotoshi Sato, Kazuyuki Sugishita, Bun Chino, Kahori Itoh, Yoshio Ikeda, Yoshihiro Shinagawa, Masaki Kondo, Yasumasa Okamoto, Hirokazu Fujita, Motomu Suga…
    Citation: BMC Medicine 2018 16:103
  46. Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved.

    Authors: Nicholas L. Syn, Andrea Li-Ann Wong, Soo-Chin Lee, Hock-Luen Teoh, James Wei Luen Yip, Raymond CS Seet, Wee Tiong Yeo, William Kristanto, Ping-Chong Bee, LM Poon, Patrick Marban, Tuck Seng Wu, Michael D. Winther, Liam R. Brunham, Richie Soong, Bee-Choo Tai…
    Citation: BMC Medicine 2018 16:104