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  1. In both Europe and the US, resident physician work hour reduction has been a source of controversy within academic medicine. In 2008, the Institute of Medicine (IOM) recommended a reduction in resident physici...

    Authors: Alexander B Blum, Farbod Raiszadeh, Sandra Shea, David Mermin, Peter Lurie, Christopher P Landrigan and Charles A Czeisler

    Citation: BMC Medicine 2010 8:33

    Content type: Research article

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  2. The frequency of mental illness amongst adolescents and its potential long-term consequences make it an important topic to research in relation to risk and protective factors. Research on the relationship betw...

    Authors: Catherine Rothon, Phil Edwards, Kamaldeep Bhui, Russell M Viner, Stephanie Taylor and Stephen A Stansfeld

    Citation: BMC Medicine 2010 8:32

    Content type: Research article

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  3. Uncomplicated lower urinary tract infections (UTI) are usually treated with antibiotics. However, there is little evidence for alternative therapeutic options.

    Authors: Jutta Bleidorn, Ildikó Gágyor, Michael M Kochen, Karl Wegscheider and Eva Hummers-Pradier

    Citation: BMC Medicine 2010 8:30

    Content type: Research article

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  4. Forced expiratory volume in one second (FEV1) is used to diagnose and establish a prognosis in chronic obstructive pulmonary disease (COPD). Using multi-dimensional scores improves this predictive capacity.Two in...

    Authors: Cristóbal Esteban, José M Quintana, Javier Moraza, Myriam Aburto, Urko Aguirre, José I Aguirregomoscorta, Susana Aizpiri, Luis V Basualdo and Alberto Capelastegui

    Citation: BMC Medicine 2010 8:28

    Content type: Research article

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  5. Breast cancer studies frequently focus on the role of the tumor microenvironment in the promotion of cancer; however, the influence of the normal breast microenvironment on cancer cells remains relatively unkn...

    Authors: Jodie M Fleming, Tyler C Miller, Mariam Quinones, Zhen Xiao, Xia Xu, Matthew J Meyer, Erika Ginsburg, Timothy D Veenstra and Barbara K Vonderhaar

    Citation: BMC Medicine 2010 8:27

    Content type: Research article

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  6. Oncogenic point mutations in KIT or PDGFRA are recognized as the primary events responsible for the pathogenesis of most gastrointestinal stromal tumors (GIST), but additional genomic alterations are frequent and...

    Authors: Mara Silva, Isabel Veiga, Franclim R Ribeiro, Joana Vieira, Carla Pinto, Manuela Pinheiro, Bárbara Mesquita, Catarina Santos, Marta Soares, José Dinis, Lúcio Santos, Paula Lopes, Mariana Afonso, Carlos Lopes and Manuel R Teixeira

    Citation: BMC Medicine 2010 8:26

    Content type: Research article

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  7. Radiation therapy has come a long way from treatment planning based on orthogonal radiographs with large margins around tumours. Advances in imaging and radiation planning software have led to three-dimensiona...

    Authors: SA Bhide and CM Nutting

    Citation: BMC Medicine 2010 8:25

    Content type: Minireview

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  8. Although current electronic methods of scientific publishing offer increased opportunities for publishing all research studies and describing them in sufficient detail, health research literature still suffers...

    Authors: Iveta Simera, David Moher, Allison Hirst, John Hoey, Kenneth F Schulz and Douglas G Altman

    Citation: BMC Medicine 2010 8:24

    Content type: Commentary

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  9. There are few studies that have investigated temporal trends in risk of recurrent stroke. The aim of this study was to examine temporal trends in hospitalisation for stroke recurrence following incident hospit...

    Authors: James Lewsey, Pardeep S Jhund, Michelle Gillies, Jim WT Chalmers, Adam Redpath, Andrew Briggs, Matthew Walters, Peter Langhorne, Simon Capewell, John JV McMurray and Kate MacIntyre

    Citation: BMC Medicine 2010 8:23

    Content type: Research article

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  10. A central element in the current debate about best practice management of non-specific low back pain (NSLBP) is the efficacy of targeted versus generic (non-targeted) treatment. Many clinicians and researchers...

    Authors: Peter Kent, Hanne L Mjøsund and Ditte HD Petersen

    Citation: BMC Medicine 2010 8:22

    Content type: Research article

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  11. Appropriate choice and use of prognostic models in clinical practice require the use of good methods for both model development, and for developing prognostic indices and risk groups from the models. In order ...

    Authors: Susan Mallett, Patrick Royston, Rachel Waters, Susan Dutton and Douglas G Altman

    Citation: BMC Medicine 2010 8:21

    Content type: Research article

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  12. Amifostine (WR-2721, delivered as Ethyol®) is a phosphorylated aminothiol compound clinically used in addition to cis-platinum to reduce the toxic side effects of therapeutic treatment on normal cells without red...

    Authors: S Dedieu, X Canron, HR Rezvani, M Bouchecareilh, F Mazurier, R Sinisi, M Zanda, M Moenner, A Bikfalvi and S North

    Citation: BMC Medicine 2010 8:19

    Content type: Research article

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  13. Acute seizures are common among children admitted to hospitals in resource poor countries. However, there is little data on the burden, causes and outcome of neonatal seizures in sub-Saharan Africa. We determi...

    Authors: Michael Mwaniki, Ali Mathenge, Samson Gwer, Neema Mturi, Evasius Bauni, Charles RJC Newton, James Berkley and Richard Idro

    Citation: BMC Medicine 2010 8:16

    Content type: Research article

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  14. The use of placebo interventions outside clinical trials is ethically, professionally and legally controversial. Little is known about the frequency and circumstances of placebo use in clinical practice. Our a...

    Authors: Margrit Fässler, Karin Meissner, Antonius Schneider and Klaus Linde

    Citation: BMC Medicine 2010 8:15

    Content type: Research article

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  15. Melanoma incidence is on the rise and advanced melanoma carries an extremely poor prognosis. Treatment options, including chemotherapy and immunotherapy, are limited and offer low response rates and transient ...

    Authors: Yixiang Wang, Soroosh Radfar, Suhu Liu, Adam I Riker and Hung T Khong

    Citation: BMC Medicine 2010 8:14

    Content type: Research article

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  16. There are currently no accurate serum markers for detecting early risk of colorectal cancer (CRC). We therefore developed a non-targeted metabolomics technology to analyse the serum of pre-treatment CRC patien...

    Authors: Shawn A Ritchie, Pearson WK Ahiahonu, Dushmanthi Jayasinghe, Doug Heath, Jun Liu, Yingshen Lu, Wei Jin, Amir Kavianpour, Yasuyo Yamazaki, Amin M Khan, Mohammad Hossain, Khine Khine Su-Myat, Paul L Wood, Kevin Krenitsky, Ichiro Takemasa, Masakazu Miyake…

    Citation: BMC Medicine 2010 8:13

    Content type: Research article

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  17. DNA-methyltransferase (DNMT)-3A plays an important role in the development of embryogenesis and the generation of aberrant methylation in carcinogenesis. The aim of this study was to investigate the role of a ...

    Authors: Hong Fan, Dongsheng Liu, Xuemei Qiu, Fengchang Qiao, Qingxiang Wu, Xianwei Su, Feng Zhang, Yunwei Song, Zhujiang Zhao and Wei Xie

    Citation: BMC Medicine 2010 8:12

    Content type: Research article

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  18. Although poorly described in the literature, the practice of early (short-interval) rescreen after a negative screening mammogram is controversial due to its financial and psychological burden and because it i...

    Authors: Alessandra Ravaioli, Flavia Foca, Americo Colamartini, Fabio Falcini, Carlo Naldoni, Alba C Finarelli, Priscilla Sassoli de Bianchi and Lauro Bucchi

    Citation: BMC Medicine 2010 8:11

    Content type: Research article

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  19. Low back pain is a highly prevalent and disabling condition worldwide. Clinical guidelines for the management of patients with acute low back pain recommend first-line treatment consisting of advice, reassuran...

    Authors: Luciana AC Machado, Chris G Maher, Rob D Herbert, Helen Clare and James H McAuley

    Citation: BMC Medicine 2010 8:10

    Content type: Research article

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  20. Chest pain raises concern for the possibility of coronary heart disease. Scoring methods have been developed to identify coronary heart disease in emergency settings, but not in primary care.

    Authors: Baris Gencer, Paul Vaucher, Lilli Herzig, François Verdon, Christiane Ruffieux, Stefan Bösner, Bernard Burnand, Thomas Bischoff, Norbert Donner-Banzhoff and Bernard Favrat

    Citation: BMC Medicine 2010 8:9

    Content type: Research article

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  21. Almost five decades ago, governments around the world adopted the 1961 Single Convention on Narcotic Drugs which, in addition to addressing the control of illicit narcotics, obligated countries to work towards...

    Authors: Diederik Lohman, Rebecca Schleifer and Joseph J Amon

    Citation: BMC Medicine 2010 8:8

    Content type: Debate

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  22. Diagnosis-based risk adjustment is becoming an important issue globally as a result of its implications for payment, high-risk predictive modelling and provider performance assessment. The Taiwanese National H...

    Authors: Hsien-Yen Chang and Jonathan P Weiner

    Citation: BMC Medicine 2010 8:7

    Content type: Research article

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  23. Inflammatory cytokines play a crucial role in coronary artery disease (CAD). We investigated the association between 48 coding and three non-coding single nucleotide polymorphisms (SNPs) from 35 inflammatory g...

    Authors: Benjamin D Brown, Jérémie Nsengimana, Jennifer H Barrett, Richard A Lawrence, Lori Steiner, Suzanne Cheng, D Timothy Bishop, Nilesh J Samani, Stephen G Ball, Anthony J Balmforth and Alistair S Hall

    Citation: BMC Medicine 2010 8:5

    Content type: Research article

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  24. The U.S. Food and Drug Administration (FDA) recently linked antiepileptic drug (AED) exposure to suicide-related behaviors based on meta-analysis of randomized clinical trials. We examined the relationship bet...

    Authors: Anne C VanCott, Joyce A Cramer, Laurel A Copeland, John E Zeber, Michael A Steinman, Jeffrey J Dersh, Mark E Glickman, Eric M Mortensen, Megan E Amuan and Mary Jo Pugh

    Citation: BMC Medicine 2010 8:4

    Content type: Research article

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  25. Platinum-based combinations are the standard second-line treatment for platinum-sensitive ovarian cancer (OC). This randomized phase II study was undertaken in order to compare the combination of carboplatin a...

    Authors: Dimitrios Bafaloukos, Helena Linardou, Gerasimos Aravantinos, Christos Papadimitriou, Aristotelis Bamias, George Fountzilas, Haralabos P Kalofonos, Paris Kosmidis, Eleni Timotheadou, Thomas Makatsoris, Epaminondas Samantas, Evangelos Briasoulis, Christos Christodoulou, Pavlos Papakostas, Dimitrios Pectasides and Athanasios M Dimopoulos

    Citation: BMC Medicine 2010 8:3

    Content type: Research article

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  26. Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. Given the emerging evidence for the role of the stroma in these processes, we aimed to characterize the effec...

    Authors: Michal Rajski, Rosanna Zanetti-Dällenbach, Brigitte Vogel, Richard Herrmann, Christoph Rochlitz and Martin Buess

    Citation: BMC Medicine 2010 8:1

    Content type: Research article

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  27. Directly observed therapy (DOT) remains the cornerstone of the global tuberculosis (TB) control strategy. Tanzania, one of the 22 high-burden countries regarding TB, changed the first-line treatment regimen to...

    Authors: Saidi Egwaga, Abdallah Mkopi, Nyagosya Range, Vera Haag-Arbenz, Amuri Baraka, Penny Grewal, Frank Cobelens, Hassan Mshinda, Fred Lwilla and Frank van Leth

    Citation: BMC Medicine 2009 7:80

    Content type: Research article

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  28. It is becoming increasingly apparent that cancer drug therapies can only reach their full potential through appropriate patient selection. Matching drugs and cancer patients has proven to be a complex challeng...

    Authors: Cyril Benes and Jeff Settleman

    Citation: BMC Medicine 2009 7:78

    Content type: Commentary

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  29. Polyamines regulate important cellular functions and polyamine dysregulation frequently occurs in cancer. The objective of this study was to use a systems approach to study the relative effects of PG-11047, a ...

    Authors: Wen-Lin Kuo, Debopriya Das, Safiyyah Ziyad, Sanchita Bhattacharya, William J Gibb, Laura M Heiser, Anguraj Sadanandam, Gerald V Fontenay, Zhi Hu, Nicholas J Wang, Nora Bayani, Heidi S Feiler, Richard M Neve, Andrew J Wyrobek, Paul T Spellman, Laurence J Marton…

    Citation: BMC Medicine 2009 7:77

    Content type: Research article

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  30. Intervention coverage and funding for the control of malaria in Africa has increased in recent years, however, there are few descriptions of changing disease burden and the few reports available are from isola...

    Authors: Emelda A Okiro, Victor A Alegana, Abdisalan M Noor, Juliette J Mutheu, Elizabeth Juma and Robert W Snow

    Citation: BMC Medicine 2009 7:75

    Content type: Research article

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  31. Multiple sclerosis, the most common neurologic disorder of young adults, is traditionally considered to be an inflammatory, autoimmune, demyelinating disease of the central nervous system. Based on this unders...

    Authors: Rebecca I Spain, Michelle H Cameron and Dennis Bourdette

    Citation: BMC Medicine 2009 7:74

    Content type: Minireview

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  32. With the rise of the second pandemic wave of the novel influenza A (H1N1) virus in the current season in the Northern Hemisphere, pandemic plans are being carefully re-evaluated, particularly for the strategic...

    Authors: Seyed M Moghadas, Christopher S Bowman, Gergely Röst, David N Fisman and Jianhong Wu

    Citation: BMC Medicine 2009 7:73

    Content type: Research article

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  33. High dose oral ascorbic acid substantially improved myelination and locomotor function in a Charcot-Marie-Tooth type 1A mouse model. A phase II study was warranted to investigate whether high dose ascorbic aci...

    Authors: Camiel Verhamme, Rob J de Haan, Marinus Vermeulen, Frank Baas, Marianne de Visser and Ivo N van Schaik

    Citation: BMC Medicine 2009 7:70

    Content type: Research article

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  34. Recently published results from a large randomized trial (Canadian Cervical Cancer Screening Trial study group) suggest that human papillomavirus testing followed by Pap smear-based triage for human papillomav...

    Authors: Shalini L Kulasingam, Raghu Rajan, Yvan St Pierre, C Victoria Atwood, Evan R Myers and Eduardo L Franco

    Citation: BMC Medicine 2009 7:69

    Content type: Research article

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  35. The Signal Transducer and Activator of Transcription 1 (STAT1) has traditionally been regarded as a transmitter of interferon signaling and a pro-apoptotic tumour suppressor. Recent data have identified new fu...

    Authors: Sean P Pitroda, Bassam T Wakim, Ravi F Sood, Mara G Beveridge, Michael A Beckett, Dhara M MacDermed, Ralph R Weichselbaum and Nikolai N Khodarev

    Citation: BMC Medicine 2009 7:68

    Content type: Research article

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  36. Tuberculosis contributes significantly to morbidity and mortality among HIV-infected children in sub-Saharan Africa. Isoniazid prophylaxis can reduce tuberculosis incidence in this population. However, for the...

    Authors: Stanzi M le Roux, Mark F Cotton, Jonathan E Golub, David M le Roux, Lesley Workman and Heather J Zar

    Citation: BMC Medicine 2009 7:67

    Content type: Research article

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  37. Alzheimer's disease is the most common progressive neurodegenerative disease. In recent years, numerous progresses in the discovery of novel Alzheimer's disease molecular biomarkers in brain as well as in biol...

    Authors: Alessandra Pani, Antonella Mandas, Giacomo Diaz, Claudia Abete, Pier Luigi Cocco, Fabrizio Angius, Annalisa Brundu, Nico Muçaka, Maria Elena Pais, Antonio Saba, Luigi Barberini, Cristina Zaru, Manuela Palmas, Paolo F Putzu, Alessandra Mocali, Francesco Paoletti…

    Citation: BMC Medicine 2009 7:66

    Content type: Research article

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  38. The decreasing range of joint motion caused by insufficient muscle length is a common problem in children with cerebral palsy (CP), often worsening with age. In 1994 a CP register and health care programme for...

    Authors: Eva Nordmark, Gunnar Hägglund, Henrik Lauge-Pedersen, Philippe Wagner and Lena Westbom

    Citation: BMC Medicine 2009 7:65

    Content type: Research article

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