Skip to main content

Articles

Page 58 of 69

  1. Bone morphogenic proteins (BMPs) play a key role in bone formation. Consequently, it was expected that topical application of recombinant human (rh)BMP-2 and rhBMP-7 would improve the healing of complex fractu...

    Authors: Sabrina Ehnert, Jian Zhao, Stefan Pscherer, Thomas Freude, Steven Dooley, Andreas Kolk, Ulrich Stöckle, Andreas Klaus Nussler and Robert Hube
    Citation: BMC Medicine 2012 10:101
  2. Pathology and radiology form the core of cancer diagnosis, yet the workflows of both specialties remain ad hoc and occur in separate "silos," with no direct linkage between their case accessioning and/or reportin...

    Authors: James Sorace, Denise R Aberle, Dena Elimam, Silvana Lawvere, Ossama Tawfik and W Dean Wallace
    Citation: BMC Medicine 2012 10:100
  3. In childhood, attention deficit/hyperactivity disorder (ADHD) is characterized by age-inappropriate levels of inattentiveness/disorganization, hyperactivity/impulsiveness, or a combination thereof. Although th...

    Authors: Monica Shaw, Paul Hodgkins, Hervé Caci, Susan Young, Jennifer Kahle, Alisa G Woods and L Eugene Arnold
    Citation: BMC Medicine 2012 10:99
  4. The endotoxin level in the portal and peripheral veins of hepatocellular carcinoma (HCC) patients is higher and lipopolysaccharide (LPS), a cell wall constituent of gram-negative bacteria, has been reported to...

    Authors: Ying-Ying Jing, Zhi-Peng Han, Kai Sun, Shan-Shan Zhang, Jing Hou, Yan Liu, Rong Li, Lu Gao, Xue Zhao, Qiu-Dong Zhao, Meng-Chao Wu and Li-Xin Wei
    Citation: BMC Medicine 2012 10:98
  5. Clinical characteristics and outcomes of intracranial hemorrhage (ICH) among adult patients with various hematological malignancies are limited.

    Authors: Chien-Yuan Chen, Chan-Hwei Tai, Aristine Cheng, Hung-Chang Wu, Woei Tsay, Jia-Hau Liu, Pey-Ying Chen, Shang-Yi Huang, Ming Yao, Jih-Luh Tang and Hwei-Fang Tien
    Citation: BMC Medicine 2012 10:97
  6. Tamoxifen has emerged as a potential management option for gynecomastia and breast pain due to non-steroidal antiandrogens, and it is considered an alternative to surgery or radiotherapy. The objective of this...

    Authors: Frank Kunath, Bastian Keck, Gerd Antes, Bernd Wullich and Joerg J Meerpohl
    Citation: BMC Medicine 2012 10:96
  7. In calcific tendinopathy (CT), calcium deposits in the substance of the tendon, with chronic activity-related pain, tenderness, localized edema and various degrees of decreased range of motion. CT is particula...

    Authors: Francesco Oliva, Alessio Giai Via and Nicola Maffulli
    Citation: BMC Medicine 2012 10:95
  8. Stem cell injection therapies have been proposed to overcome the limited efficacy and adverse reactions of bulking agents. However, most have significant limitations, including painful procurement, requirement...

    Authors: Bum Soo Kim, So Young Chun, Jong Kil Lee, Hyun Ju Lim, Jae-sung Bae, Ho-Yun Chung, Anthony Atala, Shay Soker, James J Yoo and Tae Gyun Kwon
    Citation: BMC Medicine 2012 10:94
  9. Genetic-epidemiological studies on monozygotic (MZ) twins have been used for decades to tease out the relative contributions of genes and the environment to a trait. Phenotypic discordance in MZ twins has trad...

    Authors: Witold Czyz, Julia M Morahan, George C Ebers and Sreeram V Ramagopalan
    Citation: BMC Medicine 2012 10:93
  10. Antipsychotic-induced weight gain constitutes a major unresolved clinical problem which may ultimately be associated with reducing life expectancy by 25 years. Overweight is associated with brain deterioration...

    Authors: Bjørn H Ebdrup, Filip K Knop, Pelle L Ishøy, Egill Rostrup, Birgitte Fagerlund, Henrik Lublin and Birte Glenthøj
    Citation: BMC Medicine 2012 10:92
  11. N-acetyl cysteine (NAC) is a glutathione precursor that has been shown to have antidepressant efficacy in a placebo-controlled trial. The current study aimed to investigate the maintenance effects of NAC follo...

    Authors: Michael Berk, Olivia M Dean, Sue M Cotton, Clarissa S Gama, Flavio Kapczinski, Brisa Fernandes, Kristy Kohlmann, Susan Jeavons, Karen Hewitt, Kirsteen Moss, Christine Allwang, Ian Schapkaitz, Heidi Cobb, Ashley I Bush, Seetal Dodd and Gin S Malhi
    Citation: BMC Medicine 2012 10:91
  12. Over the past few decades, the emergence of multidrug resistance (MDR) to antibiotics in bacteria has led to major difficulties in the management of infected patients. At present, there is a serious lack of de...

    Authors: Albert Sotto and Jean-Philippe Lavigne
    Citation: BMC Medicine 2012 10:90
  13. Recent insights provide support for the treatment of cancer during pregnancy, a coincidence that poses both mother and fetus at risk. Our aim was to critically review studies on the physiologic variations duri...

    Authors: Sileny N Han, Anouk Lotgerink, Mina Mhallem Gziri, Kristel Van Calsteren, Myriam Hanssens and Frédéric Amant
    Citation: BMC Medicine 2012 10:86
  14. Colorectal cancer (CRC), which frequently metastasizes to the liver, is one of the three leading causes of cancer-related deaths worldwide. Growing evidence suggests that a subset of cells exists among cancer ...

    Authors: Shan-shan Zhang, Zhi-peng Han, Ying-ying Jing, Shuang-fen Tao, Tie-jun Li, Hao Wang, Yang Wang, Rong Li, Yang Yang, Xue Zhao, Xiao-dong Xu, En-da Yu, Yao-cheng Rui, Hou-jia Liu, Li Zhang and Li-xin Wei
    Citation: BMC Medicine 2012 10:85
  15. Germinal center kinase-like kinase (GLK, also termed MAP4K3), a member of the MAP4K family, may regulate gene transcription, apoptosis and immune inflammation in response to extracellular signals. The enhanced...

    Authors: Der-Yuan Chen, Huai-Chia Chuang, Joung-Liang Lan, Yi-Ming Chen, Wei-Ting Hung, Kuo-Lung Lai and Tse-Hua Tan
    Citation: BMC Medicine 2012 10:84
  16. Social media includes many different forms of technology including online forums, blogs, microblogs (i.e. Twitter), wikipedias, video blogs, social networks and podcasting. The use of social media has grown ex...

    Authors: Farris K Timimi
    Citation: BMC Medicine 2012 10:83
  17. Rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis are immune-mediated inflammatory diseases with similarities in pathophysiology, and all can be treated with similar biological agents....

    Authors: Nienke Lesuis, Ragnar Befrits, Filippa Nyberg and Ronald F van Vollenhoven
    Citation: BMC Medicine 2012 10:82
  18. Treatment of large bone defects represents a great challenge in orthopedic and craniomaxillofacial surgery. Although there are several methods for bone reconstruction, they all have specific indications and li...

    Authors: Rozalia Dimitriou, George I Mataliotakis, Giorgio Maria Calori and Peter V Giannoudis
    Citation: BMC Medicine 2012 10:81
  19. The TransEurope FootRace 2009 (TEFR09) was one of the longest transcontinental ultramarathons with an extreme endurance physical load of running nearly 4,500 km in 64 days. The aim of this study was to assess ...

    Authors: Uwe HW Schütz, Arno Schmidt-Trucksäss, Beat Knechtle, Jürgen Machann, Heike Wiedelbach, Martin Ehrhardt, Wolfgang Freund, Stefan Gröninger, Horst Brunner, Ingo Schulze, Hans-Jürgen Brambs and Christian Billich
    Citation: BMC Medicine 2012 10:78
  20. It is recognised that regular physical activity and a high level of fitness are powerful predictors of positive health outcomes. There is a long and rich history of significant feats of human endurance with so...

    Authors: Andrew Murray and Ricardo JS Costa
    Citation: BMC Medicine 2012 10:76
  21. Lower limb injuries in sport are increasingly prevalent and responsible for large economic as well as personal burdens. In this review we seek to determine which easily implemented functional neuromuscular war...

    Authors: Katherine Herman, Christian Barton, Peter Malliaras and Dylan Morrissey
    Citation: BMC Medicine 2012 10:75
  22. London 2012 is the first Olympic and Paralympic Games to explicitly try and develop socioeconomic legacies for which success indicators are specified - the highest profile of which was to deliver a health lega...

    Authors: Garry A Tew, Robert J Copeland and Simon H Till
    Citation: BMC Medicine 2012 10:74
  23. Probiotic lactic acid bacteria (LAB) support a functional and balanced immune system, and contribute to immune modulatory effects in combatting microbial pathogens, including viruses. Most cervical cancers are...

    Authors: Min-Kyeong Cha, Do-Kyung Lee, Hyang-Mi An, Si-Won Lee, Seon-Hee Shin, Jeong-Hyun Kwon, Kyung-Jae Kim and Nam-Joo Ha
    Citation: BMC Medicine 2012 10:72
  24. Clinical pathways (CPs) are used to improve the outcomes of acute stroke, but their use in stroke care is questionable, because the evidence on their effectiveness is still inconclusive. The objective of this ...

    Authors: Massimiliano Panella, Sara Marchisio, Romeo Brambilla, Kris Vanhaecht and Francesco Di Stanislao
    Citation: BMC Medicine 2012 10:71
  25. A season of birth effect in immune-mediated diseases (ID) such as multiple sclerosis and type 1 diabetes has been consistently reported. We aimed to investigate whether season of birth influences the risk of r...

    Authors: Giulio Disanto, George Chaplin, Julia M Morahan, Gavin Giovannoni, Elina Hyppönen, George C Ebers and Sreeram V Ramagopalan
    Citation: BMC Medicine 2012 10:69
  26. Patients experience an increasing treatment burden related to everything they do to take care of their health: visits to the doctor, medical tests, treatment management and lifestyle changes. This treatment bu...

    Authors: Viet-Thi Tran, Victor M Montori, David T Eton, Dan Baruch, Bruno Falissard and Philippe Ravaud
    Citation: BMC Medicine 2012 10:68
  27. Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression. ...

    Authors: Emanuel Severus, Florian Seemüller, Michael Berger, Sandra Dittmann, Michael Obermeier, Andrea Pfennig, Michael Riedel, Sophia Frangou, Hans-Jürgen Möller and Michael Bauer
    Citation: BMC Medicine 2012 10:67
  28. It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated...

    Authors: Michael Maes, Michael Berk, Lisa Goehler, Cai Song, George Anderson, Piotr Gałecki and Brian Leonard
    Citation: BMC Medicine 2012 10:66
  29. The autism rate has recently increased to 1 in 100 children. Genetic studies demonstrate poorly understood complexity. Environmental factors apparently also play a role. Magnetic resonance imaging (MRI) studie...

    Authors: Frank H Duffy and Heidelise Als
    Citation: BMC Medicine 2012 10:64
  30. A series of primarily laboratory-based studies found attention bias modification in socially anxious participants to lead to reduced anxiety. It is argued that the failure to replicate the positive results of ...

    Authors: Paul MG Emmelkamp
    Citation: BMC Medicine 2012 10:63
  31. The benefit of the coronary collateral circulation (natural bypass network) on survival is well established. However, data derived from smaller studies indicates that coronary collaterals may increase the risk...

    Authors: Pascal Meier, Andreas Indermuehle, Bertram Pitt, Tobias Traupe, Stefano F de Marchi, Tom Crake, Guido Knapp, Alexandra J Lansky and Christian Seiler
    Citation: BMC Medicine 2012 10:62
  32. The 'exposome' represents the accumulation of all environmental exposures across a lifetime. Top-down strategies are required to assess something this comprehensive, and could transform our understanding of ho...

    Authors: James K Ellis, Toby J Athersuch, Laura DK Thomas, Friederike Teichert, Miriam Pérez-Trujillo, Claus Svendsen, David J Spurgeon, Rajinder Singh, Lars Järup, Jacob G Bundy and Hector C Keun
    Citation: BMC Medicine 2012 10:61
  33. Failure rates in postgraduate examinations are often high and many candidates therefore retake examinations on several or even many times. Little, however, is known about how candidates perform across those mu...

    Authors: IC McManus and Katarzyna Ludka
    Citation: BMC Medicine 2012 10:60
  34. The term non-specific chest pain (NSCP) is applied to hospitalized patients in order to designate that they neither have an acute coronary syndrome (ACS) nor display evidence of a coronary ischemia. The number...

    Authors: Vidar Ruddox, Mariann Mathisen and Jan Erik Otterstad
    Citation: BMC Medicine 2012 10:58
  35. Corticosteroids are standard treatment for patients with multiple sclerosis experiencing acute relapse. Because dyspeptic pain is a common side effect of this intervention, patients can be given a histamine re...

    Authors: Sangita Biswas, Stephen H Benedict, Sharon G Lynch and Steven M LeVine
    Citation: BMC Medicine 2012 10:57
  36. Stem cell-based therapy to treat liver diseases is a focus of current research worldwide. So far, most such studies depend on rodent hepatic failure models. The purpose of this study was to isolate mesenchymal...

    Authors: Hongcui Cao, Jinfeng Yang, Jiong Yu, Qiaoling Pan, Jianzhou Li, Pengcheng Zhou, Yanyuan Li, Xiaoping Pan, Jun Li, Yingjie Wang and Lanjuan Li
    Citation: BMC Medicine 2012 10:56
  37. Many immigrant populations lack access to primary health care. A recently published study on cholesterol screening among immigrant populations in the US found disparities in cholesterol screening in those orig...

    Authors: Mark Fort Harris
    Citation: BMC Medicine 2012 10:55
  38. Metabolic syndrome (METS) is an increasingly prevalent but poorly understood clinical condition characterized by insulin resistance, glucose intolerance, dyslipidemia, hypertension, and obesity. Increased oxid...

    Authors: Khosrow S Houschyar, Rainer Lüdtke, Gustav J Dobos, Ulrich Kalus, Martina Broecker-Preuss, Thomas Rampp, Benno Brinkhaus and Andreas Michalsen
    Citation: BMC Medicine 2012 10:54