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Table 1 Genetic correlation between autoimmune diseases and B-ALL

From: Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis

Trait pairs

LDSC

HDL

rg (SE)

P

rg (SE)

P

B-ALL&AOA

0.156 (0.078)

0.045

0.159 (0.062)

0.010

B-ALL&COA

0.046 (0.073)

0.529

 − 0.012 (0.056)

0.835

B-ALL&GD

0.025 (0.151)

0.871

0.012 (0.133)

0.931

B-ALL&HD

0.256 (0.145)

0.077

0.281 (0.165)

0.089

B-ALL&HT

0.167 (0.081)

0.039

0.171 (0.065)

0.008

B-ALL&PBC

0.091 (0.097)

0.350

0.205 (0.104)

0.049

B-ALL&PSC

 − 0.072 (0.128)

0.573

/

/

B-ALL&IBD

0.175 (0.082)

0.033

0.05 (0.053)

0.353

B-ALL&CD

0.234 (0.101)

0.020

0.063 (0.062)

0.311

B-ALL&UC

0.081 (0.084)

0.335

0.025 (0.062)

0.682

B-ALL&RA

0.383 (0.101)

1 × 10–4

0.214 (0.067)

1.32 × 10–3

B-ALL&MS

0.219 (0.084)

0.009

0.142 (0.057)

0.013

B-ALL&SS

0.212 (0.166)

0.203

/

/

B-ALL&SLE

0.064 (0.117)

0.581

0.008 (0.076)

0.917

B-ALL&T1D

0.044 (0.137)

0.746

0.105 (0.102)

0.305

B-ALL&Vitiligo

0.032 (0.097)

0.745

0.026 (0.066)

0.693

  1. LDSC linkage disequilibrium score regression, HDL high-definition likelihood, SE standard error, B-ALL B-cell acute lymphoblastic leukemia, AOA adult-onset asthma, COA childhood-onset asthma, GD Grave’s disease, HD Hashimoto’s disease, HT hypothyroidism, PBC primary biliary cirrhosis, PSC primary sclerosing cholangitis, IBD inflammatory bowel disease, CD Crohn’s disease, UC ulcerative colitis, RA rheumatoid arthritis, MS multiple sclerosis, SS systemic sclerosis, SLE systemic lupus erythematosus, T1D type 1 diabetes
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BMC Medicine

ISSN: 1741-7015

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