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Table 2 16 colocalized loci identified by colocalization analysis performed on 73 pleiotropic loci (PP.H4 > 0.7)

From: Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis

Trait pairs

Locus boundary

Region

Nearest genes

Lead SNPs

P

PP H4

B-ALL&AOA

2:145800791–146642994

2q22.3

RPL6P5, AC092484.1

rs12992327

2.61 × 10–08

0.772

B-ALL&AOA

5:130812049–132489413

5q31.1

C5orf56

rs11741255

3.61 × 10–13

0.798

B-ALL&HT

6:135176498–135536586

6q23.3

HBS1L

rs2210366

1.84 × 10–08

0.854

B-ALL&IBD

5:130437485–132319450

5q31.1

snoZ6, AC063976.1

rs27437

2.66 × 10–13

0.713

B-ALL&IBD

6:111398304–112528738

6q21

TRAF3IP2

rs33980500

2.61 × 10–09

0.942

B-ALL&IBD

10:100601902–101268250

10q24.2

RP11-441O15.3, RP11-129J12.2

rs2490285

2.66 × 10–08

0.903

B-ALL&IBD

10:126192582–126590319

10q26.13

METTL10, RP11-12J10.3

rs11245358

2.36 × 10–08

0.907

B-ALLIBD

17:37486160–38384187

17q12

ZPBP2, GSDMB

rs117504211

1.47 × 10–08

0.961

B-ALL&MS

6:135195857–135581900

6q23.3

HBS1L, MYB

rs9494168

1.39 × 10–08

0.953

B-ALL&MS

8:78606328–79845682

8q21.12

ZC2HC1A

rs10102877

1.97 × 10–09

0.884

B-ALL&MS

21:39835031–39945134

21q22.2

ERG

rs2836438

5.16 × 10–09

0.958

B-ALL&PBC

3:159455579–159818194

3q25.33

IQCJ-SCHIP1

rs13072356

1.41 × 10–08

0.742

B-ALL&PBC

5:35078698–36482458

5p13.2

CAPSL

rs115727000

3.54 × 10–08

0.848

B-ALL&PBC

6:33187355–33806276

6p21.31

BAK1

rs210134

8.03 × 10–10

0.981

B-ALL&PBC

14:93049865–93131795

14q32.12

RIN3

rs72699846

8.64 × 10–10

0.734

B-ALL&RA

13:28490592–28665187

13q12.2

FLT3

rs9512977

4.3 × 10–09

0.872

  1. Lead SNP was the SNP with minimum P values within the corresponding locus. PP.H4 was the posterior probability of H4 calculated by coloc analysis; the Locus boundary was defined as “chromosome: start–end”
  2. PP.H4 the posterior probability of H4, B-ALL B-cell acute lymphoblastic leukemia, AOA adult-onset asthma, HT hypothyroidism, PBC primary biliary cirrhosis, IBD inflammatory bowel disease, CD Crohn’s disease, RA rheumatoid arthritis, MS multiple sclerosis