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  1. Research article

    Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer

    Despite an early response to platinum-based chemotherapy in advanced stage high-grade serous ovarian cancer (HGSOC), the majority of patients will relapse with drug-resistant disease. Aberrant epigenetic alter...

    Tushar Tomar, Nicolette G. Alkema, Leroy Schreuder, Gert Jan Meersma, Tim de Meyer, Wim van Criekinge, Harry G. Klip, Heidi Fiegl, Els van Nieuwenhuysen, Ignace Vergote, Martin Widschwendter, Ed Schuuring, Ate G. J. van der Zee, Steven de Jong and G. Bea A. Wisman

    BMC Medicine 2017 15:116

    Published on: 23 June 2017

  2. Research article

    Influence of the number and timing of malaria episodes during pregnancy on prematurity and small-for-gestational-age in an area of low transmission

    Most evidence on the association between malaria in pregnancy and adverse pregnancy outcomes focuses on falciparum malaria detected at birth. We assessed the association between the number and timing of falcip...

    Kerryn A. Moore, Julie A. Simpson, Jacher Wiladphaingern, Aung Myat Min, Mupawjay Pimanpanarak, Moo Kho Paw, Jathee Raksuansak, Sasithon Pukrittayakamee, Freya J. I. Fowkes, Nicholas J. White, François Nosten and Rose McGready

    BMC Medicine 2017 15:117

    Published on: 21 June 2017

  3. Research article

    The effect of weekly specialist palliative care teleconsultations in patients with advanced cancer –a randomized clinical trial

    Teleconsultation seems to be a promising intervention for providing palliative care to home-dwelling patients; however, its effect on clinically relevant outcome measures remains largely unexplored. Therefore,...

    Patrick D. Hoek, Henk J. Schers, Ewald M. Bronkhorst, Kris C. P. Vissers and Jeroen G. J. Hasselaar

    BMC Medicine 2017 15:119

    Published on: 19 June 2017

  4. Research article

    Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea

    γδ T cells are important for both protective immunity and immunopathogenesis during malaria infection. However, the immunological processes determining beneficial or detrimental effects on disease outcome rema...

    Louis Schofield, Lisa J. Ioannidis, Stephan Karl, Leanne J. Robinson, Qiao Y. Tan, Daniel P. Poole, Inoni Betuela, Danika L. Hill, Peter M. Siba, Diana S. Hansen, Ivo Mueller and Emily M. Eriksson

    BMC Medicine 2017 15:114

    Published on: 15 June 2017

  5. Research article

    Recent household transmission of tuberculosis in England, 2010–2012: retrospective national cohort study combining epidemiological and molecular strain typing data

    We estimate the proportion of tuberculosis (TB) in England due to recent household transmission, identify factors associated with being a household transmitter, and investigate the impact that identification o...

    Maeve K. Lalor, Laura F. Anderson, Esther L. Hamblion, Andy Burkitt, Jennifer A. Davidson, Helen Maguire, Ibrahim Abubakar and H. Lucy Thomas

    BMC Medicine 2017 15:105

    Published on: 13 June 2017

  6. Research article

    Assessing the efficiency of catch-up campaigns for the introduction of pneumococcal conjugate vaccine: a modelling study based on data from PCV10 introduction in Kilifi, Kenya

    The World Health Organisation recommends the use of catch-up campaigns as part of the introduction of pneumococcal conjugate vaccines (PCVs) to accelerate herd protection and hence PCV impact. The value of a c...

    Stefan Flasche, John Ojal, Olivier Le Polain de Waroux, Mark Otiende, Katherine L. O’Brien, Moses Kiti, D. James Nokes, W John Edmunds and J. Anthony G. Scott

    BMC Medicine 2017 15:113

    Published on: 7 June 2017

  7. Research article

    Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma

    Cutaneous melanoma is the deadliest skin cancer, with an increasing incidence and mortality rate. Currently, staging of patients with primary melanoma is performed using histological biomarkers such as tumor t...

    Jasper Wouters, Miguel Vizoso, Anna Martinez-Cardus, F. Javier Carmona, Olivier Govaere, Teresa Laguna, Jesuchristopher Joseph, Peter Dynoodt, Claudia Aura, Mona Foth, Roy Cloots, Karin van den Hurk, Balazs Balint, Ian G. Murphy, Enda W. McDermott, Kieran Sheahan…

    BMC Medicine 2017 15:101

    Published on: 5 June 2017

  8. Research article

    Number needed to treat (NNT) in clinical literature: an appraisal

    The number needed to treat (NNT) is an absolute effect measure that has been used to assess beneficial and harmful effects of medical interventions. Several methods can be used to calculate NNTs, and they shou...

    Diogo Mendes, Carlos Alves and Francisco Batel-Marques

    BMC Medicine 2017 15:112

    Published on: 1 June 2017

  9. Minireview

    The genetics of gout: towards personalised medicine?

    Over the last decade, there have been major advances in the understanding of the genetic basis of hyperuricaemia and gout as well as of the pharmacogenetics of urate-lowering therapy. Key findings include the ...

    Nicola Dalbeth, Lisa K. Stamp and Tony R. Merriman

    BMC Medicine 2017 15:108

    Published on: 31 May 2017

  10. Minireview

    When less may be more: calorie restriction and response to cancer therapy

    Calorie restriction (CR) extends lifespan and has been shown to reduce age-related diseases including cancer, diabetes, and cardiovascular and neurodegenerative diseases in experimental models. Recent translat...

    Ciara H. O’Flanagan, Laura A. Smith, Shannon B. McDonell and Stephen D. Hursting

    BMC Medicine 2017 15:106

    Published on: 24 May 2017

  11. Research article

    How many people will need palliative care in 2040? Past trends, future projections and implications for services

    Current estimates suggest that approximately 75% of people approaching the end-of-life may benefit from palliative care. The growing numbers of older people and increasing prevalence of chronic illness in many...

    S. N. Etkind, A. E. Bone, B. Gomes, N. Lovell, C. J. Evans, I. J. Higginson and F. E. M. Murtagh

    BMC Medicine 2017 15:102

    Published on: 18 May 2017

  12. Research article

    ING3 promotes prostate cancer growth by activating the androgen receptor

    The androgen receptor (AR) is a major driver of prostate cancer, and increased AR levels and co-activators of the receptor promote the development of prostate cancer. INhibitor of Growth (ING) proteins target ...

    Arash Nabbi, Urszula L. McClurg, Subhash Thalappilly, Amal Almami, Mahsa Mobahat, Tarek A. Bismar, Olivier Binda and Karl T. Riabowol

    BMC Medicine 2017 15:103

    Published on: 16 May 2017

  13. Research article

    Mediation of the effect of malaria in pregnancy on stillbirth and neonatal death in an area of low transmission: observational data analysis

    Malaria in pregnancy is preventable and contributes significantly to the estimated 5.5 million stillbirths and neonatal deaths that occur annually. The contribution of malaria in pregnancy in areas of low tran...

    Kerryn A. Moore, Freya J. I. Fowkes, Jacher Wiladphaingern, Nan San Wai, Moo Kho Paw, Mupawjay Pimanpanarak, Verena I. Carrara, Jathee Raksuansak, Julie A. Simpson, Nicholas J. White, François Nosten and Rose McGready

    BMC Medicine 2017 15:98

    Published on: 10 May 2017

  14. Research article

    Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies

    Whether habitual coffee consumption interacts with the genetic predisposition to obesity in relation to body mass index (BMI) and obesity is unknown.

    Tiange Wang, Tao Huang, Jae H. Kang, Yan Zheng, Majken K. Jensen, Janey L. Wiggs, Louis R. Pasquale, Charles S. Fuchs, Hannia Campos, Eric B. Rimm, Walter C. Willett, Frank B. Hu and Lu Qi

    BMC Medicine 2017 15:97

    Published on: 9 May 2017

  15. Research article

    Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes

    Pregnant women with epilepsy frequently experience seizures related to pregnancy complications and are often prescribed anti-epileptic drugs (AEDs) to manage their symptoms. However, less is known about the co...

    Areti Angeliki Veroniki, Elise Cogo, Patricia Rios, Sharon E. Straus, Yaron Finkelstein, Ryan Kealey, Emily Reynen, Charlene Soobiah, Kednapa Thavorn, Brian Hutton, Brenda R. Hemmelgarn, Fatemeh Yazdi, Jennifer D’Souza, Heather MacDonald and Andrea C. Tricco

    BMC Medicine 2017 15:95

    Published on: 5 May 2017

  16. Research article

    Expedited Partner Therapy (EPT) increases the frequency of partner notification among MSM in Lima, Peru: a pilot randomized controlled trial

    Expedited Partner Therapy (EPT) has been shown to improve treatment outcomes among heterosexual partners of individuals with curable sexually transmitted infections (STIs). Although the use of EPT with men who...

    Jesse L. Clark, Eddy R. Segura, Catherine E. Oldenburg, Jessica Rios, Silvia M. Montano, Amaya Perez-Brumer, Manuel Villaran, Jorge Sanchez, Thomas J. Coates and Javier R. Lama

    BMC Medicine 2017 15:94

    Published on: 4 May 2017

  17. Correspondence

    Late presentation of chronic viral hepatitis for medical care: a consensus definition

    We present two consensus definitions of advanced and late stage liver disease being used as epidemiological tools. These definitions can be applied to assess the morbidity caused by liver diseases in different...

    Stefan Mauss, Stanislas Pol, Maria Buti, Erika Duffell, Charles Gore, Jeffrey V. Lazarus, Hilje Logtenberg-van der Grient, Jens Lundgren, Antons Mozalevskis, Dorthe Raben, Eberhard Schatz, Stefan Wiktor and Jürgen K. Rockstroh

    BMC Medicine 2017 15:92

    Published on: 3 May 2017

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