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  1. Commentary

    When is proton pump inhibitor use appropriate?

    Proton pump inhibitor (PPI) therapy is commonly used outside of Food and Drug Administration indication for a broad range of conditions such as extra-esophageal reflux and PPI-responsive esophageal eosinophili...

    Rena Yadlapati and Peter J. Kahrilas

    BMC Medicine 2017 15:36

    Published on: 21 February 2017

  2. Research article

    Pain relief that matters to patients: systematic review of empirical studies assessing the minimum clinically important difference in acute pain

    The minimum clinically important difference (MCID) is used to interpret the clinical relevance of results reported by trials and meta-analyses as well as to plan sample sizes in new studies. However, there is ...

    Mette Frahm Olsen, Eik Bjerre, Maria Damkjær Hansen, Jørgen Hilden, Nino Emanuel Landler, Britta Tendal and Asbjørn Hróbjartsson

    BMC Medicine 2017 15:35

    Published on: 20 February 2017

  3. Research article

    Intranasal oxytocin reduces provoked symptoms in female patients with posttraumatic stress disorder despite exerting sympathomimetic and positive chronotropic effects in a randomized controlled trial

    Posttraumatic stress disorder (PTSD) is a severe psychiatric disease accompanied by neuroendocrine changes such as adrenergic overdrive and hence an elevated cardiovascular morbidity. Current pharmacotherapeut...

    M. Sack, D. Spieler, L. Wizelman, G. Epple, J. Stich, M. Zaba and U. Schmidt

    BMC Medicine 2017 15:40

    Published on: 17 February 2017

  4. Research article

    Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery

    The ileal-derived hormone, fibroblast growth factor 19 (FGF-19), may promote weight loss and facilitate type-2 diabetes mellitus remission in bariatric surgical patients. We investigated the effect of differen...

    Lucia Martinez de la Escalera, Ioannis Kyrou, Jana Vrbikova, Voitech Hainer, Petra Sramkova, Martin Fried, Milan K. Piya, Sudhesh Kumar, Gyanendra Tripathi and Philip G. McTernan

    BMC Medicine 2017 15:34

    Published on: 16 February 2017

  5. Research article

    Financial barriers and adverse clinical outcomes among patients with cardiovascular-related chronic diseases: a cohort study

    Some patients with cardiovascular-related chronic diseases such as diabetes and heart disease report financial barriers to achieving optimal health. Previous surveys report that the perception of having a fina...

    David J. T. Campbell, Braden J. Manns, Robert G. Weaver, Brenda R. Hemmelgarn, Kathryn M. King-Shier and Claudia Sanmartin

    BMC Medicine 2017 15:33

    Published on: 15 February 2017

  6. Research article

    The effect of an antenatal lifestyle intervention in overweight and obese women on circulating cardiometabolic and inflammatory biomarkers: secondary analyses from the LIMIT randomised trial

    Maternal overweight and obesity during pregnancy is associated with insulin resistance, hyperglycaemia, hyperlipidaemia and a low-grade state of chronic inflammation. The aim of this pre-specified analysis of ...

    Lisa J. Moran, Louise M. Fraser, Tulika Sundernathan, Andrea R. Deussen, Jennie Louise, Lisa N. Yelland, Rosalie M. Grivell, Anne Macpherson, Matthew W. Gillman, Jeffrey S. Robinson, Julie A. Owens and Jodie M. Dodd

    BMC Medicine 2017 15:32

    Published on: 14 February 2017

  7. Review

    Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer’s disease

    The vascular contributions to neurodegeneration and neuroinflammation may be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review summarises the methodology for these widely avail...

    Branko Malojcic, Panteleimon Giannakopoulos, Farzaneh A. Sorond, Elsa Azevedo, Marina Diomedi, Janja Pretnar Oblak, Nicola Carraro, Marina Boban, Laszlo Olah, Stephan J. Schreiber, Aleksandra Pavlovic, Zsolt Garami, Nantan M. Bornstein and Bernhard Rosengarten

    BMC Medicine 2017 15:27

    Published on: 9 February 2017

  8. Research article

    Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort

    Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL)...

    Renée T. Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Domenico Palli, Sabina Sieri…

    BMC Medicine 2017 15:26

    Published on: 8 February 2017

  9. Research article

    Comparison of the effects of fibrates versus statins on plasma lipoprotein(a) concentrations: a systematic review and meta-analysis of head-to-head randomized controlled trials

    Raised plasma lipoprotein(a) (Lp(a)) concentration is an independent and causal risk factor for atherosclerotic cardiovascular disease. Several types of pharmacological approaches are under evaluation for thei...

    Amirhossein Sahebkar, Luis E. Simental-Mendía, Gerald F. Watts, Maria-Corina Serban and Maciej Banach

    BMC Medicine 2017 15:22

    Published on: 3 February 2017

  10. Research article

    What is the association of hypothyroidism with risks of cardiovascular events and mortality? A meta-analysis of 55 cohort studies involving 1,898,314 participants

    Whether hypothyroidism is an independent risk factor for cardiovascular events is still disputed. We aimed to assess the association between hypothyroidism and risks of cardiovascular events and mortality.

    Yu Ning, Yun J. Cheng, Li J. Liu, Jaskanwal D. S. Sara, Zhi Y. Cao, Wei P. Zheng, Tian S. Zhang, Hui J. Han, Zhen Y. Yang, Yi Zhang, Fei L. Wang, Rui Y. Pan, Jie L. Huang, Ling L. Wu, Ming Zhang and Yong X. Wei

    BMC Medicine 2017 15:21

    Published on: 2 February 2017

  11. Research article

    Which patients with advanced respiratory disease die in hospital? A 14-year population-based study of trends and associated factors

    Strategies in many countries have sought to improve palliative care and reduce hospital deaths for non-cancer patients, but their effects are not evaluated. We aimed to determine the trends and factors associa...

    Irene J. Higginson, Charles C. Reilly, Sabrina Bajwah, Matthew Maddocks, Massimo Costantini and Wei Gao

    BMC Medicine 2017 15:19

    Published on: 1 February 2017

  12. Research article

    A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)

    The possible therapeutic impact of dietary changes on existing mental illness is largely unknown. Using a randomised controlled trial design, we aimed to investigate the efficacy of a dietary improvement progr...

    Felice N. Jacka, Adrienne O’Neil, Rachelle Opie, Catherine Itsiopoulos, Sue Cotton, Mohammedreza Mohebbi, David Castle, Sarah Dash, Cathrine Mihalopoulos, Mary Lou Chatterton, Laima Brazionis, Olivia M. Dean, Allison M. Hodge and Michael Berk

    BMC Medicine 2017 15:23

    Published on: 30 January 2017

  13. Research article

    Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study

    Cardiovascular disease (CVD) is a common comorbidity in people with asthma. However, safety concerns have caused heterogeneity in clinical guideline recommendations over the use of cardioselective beta-blocker...

    Daniel R. Morales, Brian J. Lipworth, Peter T. Donnan, Cathy Jackson and Bruce Guthrie

    BMC Medicine 2017 15:18

    Published on: 27 January 2017

  14. Commentary

    A step forward in addressing cancer survivorship in the Asia-Pacific region

    Cancer survivorship is being increasingly recognized as an important component of cancer care. This commentary reviews the key findings reported in the recent BMC Medicine publication of the ACTION study, which f...

    Raymond Javan Chan, Alexandre Chan, Patsy Yates and Alex Molassiotis

    BMC Medicine 2017 15:17

    Published on: 26 January 2017

  15. Minireview

    Translational models for vascular cognitive impairment: a review including larger species

    Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we revie...

    Atticus H. Hainsworth, Stuart M. Allan, Johannes Boltze, Catriona Cunningham, Chad Farris, Elizabeth Head, Masafumi Ihara, Jeremy D. Isaacs, Raj N. Kalaria, Saskia A. M. J. Lesnik Oberstein, Mark B. Moss, Björn Nitzsche, Gary A. Rosenberg, Julie W. Rutten, Melita Salkovic-Petrisic and Aron M. Troen

    BMC Medicine 2017 15:16

    Published on: 25 January 2017

  16. Minireview

    Procalcitonin-guided diagnosis and antibiotic stewardship revisited

    Several controlled clinical studies have evaluated the potential of the infection biomarker procalcitonin (PCT) to improve the diagnostic work-up of patients with bacterial infections and its influence on deci...

    Ramon Sager, Alexander Kutz, Beat Mueller and Philipp Schuetz

    BMC Medicine 2017 15:15

    Published on: 24 January 2017

  17. Research article

    Can screening instruments accurately determine poor outcome risk in adults with recent onset low back pain? A systematic review and meta-analysis

    Delivering efficient and effective healthcare is crucial for a condition as burdensome as low back pain (LBP). Stratified care strategies may be worthwhile, but rely on early and accurate patient screening usi...

    Emma L. Karran, James H. McAuley, Adrian C. Traeger, Susan L. Hillier, Luzia Grabherr, Leslie N. Russek and G. Lorimer Moseley

    BMC Medicine 2017 15:13

    Published on: 19 January 2017

    The Erratum to this article has been published in BMC Medicine 2017 15:44

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