Bioinformatic identification of proteins with tissue-specific expression for biomarker discovery

Table 4 List of lung tissue-specific proteins which have not been previously studied as serum cancer or benign disease biomarkers

Gene	Protein name	Proteome identified in:
		CM proteome from lung cancer cell lines [27, 52]	Non-lung proteome
*IRX5*	Iroquois homeobox 5
*LAMP3*	Lysosomal-associated membrane protein 3
*MFAP4*	Microfibrillar-associated protein 4		√ Normal and cancer pancreatic tissue^a, seminal plasma proteome [25]; non-malignant peritoneal fluid [26]
*SCGB1A1*	Secretoglobin, family 1A, member 1 (uteroglobin)		√ [22, 23, 25, 26, 31–33]
*TMEM100*	Transmembrane protein 100

^aProteome of normal and cancer pancreatic tissue (H Kosanam et al., unpublished work). CM: conditioned media.

ISSN: 1741-7015