Category | Factors |
---|---|
Environmental | Diet (sodium) [2] |
Bioavailability | Absorption, First pass metabolism (intestinal and phase 1 drugmetabolism, polymorphisms cytochrome P450 enzymes, phase 2 drugmetabolism) [6, 9] |
Distribution | Protein binding, distribution volume |
Receptor | |
Hemodynamics | Low renin, sodium-volume dependent hypertension [2] |
Intracellular effects | Nitric oxide, cGMP, cAMP, calcium fluxes, ion transport, rhokinase, creatine kinase, myosin light chain kinase, myosinATPase [10–12] |
Elimination | Kidney, liver or other route |