Table 5 Maternal serum levels of the validated PE biomarkers
From: Integrating multiple ‘omics’ analyses identifies serological protein biomarkers for preeclampsia
Analyte | PE trend | Unit | Early stage | Late stage | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Normal | PE | Normal | PE | |||||||
Median | Mean | Median | Mean | Median | Mean | Median | Mean | |||
(IQR) | (SD) | (IQR) | (SD) | (IQR) | (SD) | (IQR) | (SD) | |||
PIGF | ↓ | pg/ml | 413.8 | 529.4 | 97.5 | 115.5 | 222.279 | 238.1095 | 184.488 | 202.6929 |
(224.9, 685.2) | (432.0) | (51.6, 190.7) | (83.0) | (163.6, 289.9) | (111.5) | (113.2, 223.8) | (132.7) | |||
sFlt-1 | ↑ | pg/ml | 1697.9 | 3034.0 | 19841.3 | 18646.3 | 5610.460 | 5531.241 | 14216.20 | 14414.28 |
(1128.2, 4273.9) | (2578.7) | (15728.4, 21608.6) | (3582.5) | (4191.8, 6735.8) | (1811.9) | (12347.6, 19749.3) | (5575.3) | |||
HPX | ↑ | ug/ml | 1071.2 | 984.1 | 1382.8 | 1580.7 | 954.4 | 894.15 | 1482.0 | 1347.624 |
(692.4, 1301.0) | (388.3) | (1173.6, 1787.0) | (546.5) | (538.0, 1131.6) | (331.5) | (1013.6, 1654.4) | (585.3) | |||
ADAM12 | ↑ | pg/ml | 511.3 | 584.0 | 775.0 | 920.2 | 666.4185 | 703.6862 | 883.889 | 1345.369 |
(437.7, 642.3) | (275.8) | (637.2, 1150.2) | (416.4) | (594.9, 791.8) | (217.2) | (626.7, 1367.6) | (1472.5) | |||
APO C-III | ↓ | ng/ml | 341.3 | 364.7 | 419.2 | 486.3 | 291.58 | 321.8587 | 453.789 | 585.7512 |
(249.5, 422.4) | (153.4) | (357.3, 575.5) | (187.5) | (240.7, 345.7) | (126.7) | (308.9, 725.8) | (413.1) | |||
HP | ↓ | ug/ml | 1624.1 | 1718.0 | 1181.6 | 1482.7 | 1806.74 | 1750.72 | 985.616 | 1510.514 |
(1216.0, 2274.1) | (764.1) | (684.6, 1794.1) | (1284.6) | (1190.1, 2163.1) | (684.1) | (592.0, 1880.8) | (1515.0) | |||
A2M | ↓ | ug/ml | 5796.4 | 5729.1 | 3365.1 | 4259.3 | 8141.38 | 7754.764 | 3435.427 | 4340.768 |
(3501.2, 7737.6) | (3064.1) | (2648.3, 9959.0) | (2175.8) | (5300.6, 10234.1) | (3265.1) | (2343.7, 6752.9) | (2862.5) | |||
APO-E | ↓ | ug/ml | 290.6 | 364.4 | 138.8 | 215.9 | 398.0 | 377.9 | 147.2 | 150.0235 |
(104.2, 519.0) | (301.5) | (63.0, 210.4) | (257.6) | (125.0, 478.4) | (236.3) | (60.4, 190.0) | (107.7) | |||
APO A-I | ↓ | ng/ml | 7980.1 | 8337.7 | 4945.356 | 4708.5 | 6253.298 | 6748.614 | 4724.142 | 5483.643 |
(5775.7, 11076.6) | (3158.7) | (3892.8, 5824.6) | (1707.1) | (5624.1, 7881.8) | (2287.6) | (3138.6, 7075.3) | (3794.9) | |||
RBP4 | ↓ | ng/ml | 38255.0 | 35180.4 | 38899.0 | 36931.7 | 41616.5 | 49253.5 | 33179 | 33897.47 |
(29018.5, 40955.5) | (7031.1) | (33460.5, 39895.0) | (7307.5) | (38830.5, 44429.5) | (38081.6) | (29558, 37386) | (8499.8) | |||
pikachurin | ↓ | ng/ml | 601.8 | 659.1 | 293.261 | 327.8 | 536.551 | 536.551 | 317.657 | 317.657 |
(563.8, 792.1) | (152.0) | (267.4, 367.8) | (117.5) | (459.2, 626.6) | (952.3) | (266.8, 409.7) | (623.5) | |||