Antigen | Hazard ratio (95% CI) |
Pvalue |
---|
RPI | 0.25 (0.10 to 0.60) | 0.002 |
Merozoite IgG1 | 1.09 (0.46 to 2.55) | 0.834 |
Merozoite IgG3 | 0.53 (0.21 to 1.34) | 0.185 |
MSP119
| 0.89 (0.43 to 1.87) | 0.776 |
MSP2 | 0.15 (0.04 to 0.47) | 0.001 |
MSP3 | 0.31 (0.11 to 0.86) | 0.026 |
AMA1 | 0.25 (0.10 to 0.61) | 0.002 |
EBA175 | 0.47 (0.19 to 1.14) | 0.095 |
MSP1 block 2 | 0.46 (0.18 to 1.18) | 0.109 |
- Hazard ratios comparing the risk of a clinical episode of malaria between children who had the top versus bottom tertile of antibody responses against each antigen. ELISA antibody responses against parasite schizont extract were highly correlated (Spearman’s rho = 0.764, P <0.001 and 0.730, P <0.001 for IgG1 and IgG3, respectively) with those against whole merozoite IgG and are not included in this table. AMA1, apical membrane antigen 1; CI, confidence interval; EBA, erythrocyte binding antigen; MSP, merozoite surface protein; RPI, relative phagocytosis index. Chonyi cohort, n = 109.