Antigen | Hazard ratio (95% CI) |
Pvalue |
---|
RPI | 0.20 (0.07 to 0.59) | 0.003 |
Merozoite IgG1 | 2.16 (0.25 to 18.6) | 0.482 |
Merozoite IgG3 | 0.79 (0.07 to 8.11) | 0.844 |
MSP119
| 1.66 (0.42 to 6.53) | 0.464 |
MSP2 | 0.15 (0.03 to 0.69) | 0.015 |
MSP3 | 0.98 (0.30 to 3.14) | 0.981 |
AMA1 | 0.62 (0.12 to 3.21) | 0.578 |
EBA175 | 0.72 (0.15 to 3.51) | 0.694 |
MSP1 block 2 | 0.55 (0.15 to 1.90) | 0.345 |
- Hazard ratios comparing the risk of a clinical episode of malaria between children who had the top versus bottom tertile of antibody responses against each antigen. Chonyi cohort, n = 109. A similar analysis but including only variables that were significant in the univariate analysis (Table 1) did not alter these results and is presented in Additional file 1: Table S1. AMA1, apical membrane antigen 1; CI, confidence interval; EBA, erythrocyte binding antigen; MSP, merozoite surface protein; RPI, relative phagocytosis index.